Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh
American Journal of Clinical and Experimental Medicine
Volume 3, Issue 5, September 2015, Pages: 255-259
Received: Sep. 29, 2015; Accepted: Oct. 15, 2015; Published: Oct. 30, 2015
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Authors
Mohammad Mofizul Islam, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Shahana Akhter Rahman, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mohammad Imnul Islam, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Satya Narayan Chaudhary, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mohammad Aminul Islam, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mohammed Mahbubul Islam, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Manik Kuma Talukder, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
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Abstract
Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.
Keywords
Lipid Profile, Systemic Lupus Erythematosus Disease Activity Index, Dose of Steroid
To cite this article
Mohammad Mofizul Islam, Shahana Akhter Rahman, Mohammad Imnul Islam, Satya Narayan Chaudhary, Mohammad Aminul Islam, Mohammed Mahbubul Islam, Manik Kuma Talukder, Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh, American Journal of Clinical and Experimental Medicine. Vol. 3, No. 5, 2015, pp. 255-259. doi: 10.11648/j.ajcem.20150305.20
Copyright
Copyright © 2015 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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