American Journal of Clinical and Experimental Medicine

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Adenotonsillectomy: Effect on CRP Level in Children

Received: 18 November 2015    Accepted:     Published: 18 November 2015
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Abstract

There is an increased risk of cardiovascular and cerebrovascular events in patients with obstructive sleep apnea (OSA). There are contradictory results about the correlation between serum CRP levels and OSA severity. The purpose of this work was to evaluate CRP level after adenotonsillectomy in children with clinical symptoms, suspected OSA. This cross – sectional study was conducted between 20 March 2012 and 20 November 2014. The study group was composed of 98 children that indicated adenotonsillectomy due to clinical symptom of OSA. CRP were measured before and after surgery. Of total 98 children (52 males and 46 females) with an average age of 8.14 ± 2.6 years, 14(14.3%), 29(29.6%), 44(44.9%), and 11(11.2%) patients were with adenoid grade I, II, III, and IV, respectively and in aspect of tonsil grade, 8(8.2%) with grade I, 37(37.8%) with grade II, 43(43.9%) with grade III, and 10(10.1%) were with grade IV. Comparison of the mean of CRP before and after surgery, based on preoperative adenoid grade showed a significant difference in grade III and IV before and after surgery. In aspect of tonsil grade, in grade I, II and III, the mean CRP before and after surgery showed significant difference too. We found that change of CRP level has relationship with the grade of adenoid and tonsil hypertrophy, and may be helpful marker for indication of adenotonsillectomy.

DOI 10.11648/j.ajcem.20150305.23
Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 5, September 2015)
Page(s) 275-278
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Obstructive Sleep Apnea, C-reactive Protein, Adenotonsilectomy

References
[1] Brouillette RT, Fernbach SK, Hunt CE. Obstructive sleep apnea in infants and children. The Journal of pediatrics. 1982; 100(1): 31-40.
[2] Amin RS, Carroll JL, Jeffries JL, Grone C, Bean JA, Chini B, et al. Twenty-four–hour ambulatory blood pressure in children with sleep-disordered breathing. American journal of respiratory and critical care medicine. 2004; 169(8): 950-6.
[3] Gozal D. Sleep-disordered breathing and school performance in children. Pediatrics. 1998; 102(3): 616-20.
[4] Shahar E, Whitney CW, REdline S, Lee ET, Newman AB, Javier Nieto F, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. American journal of respiratory and critical care medicine. 2001; 163(1): 19-25.
[5] Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Jama. 2000; 283(14): 1829-36.
[6] Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. New England Journal of Medicine. 2000; 342(19): 1378-84.
[7] Ferranti SD, Rifai N. C-reactive protein: a nontraditional serum marker of cardiovascular risk. Cardiovascular Pathology. 2007; 16(1): 14-21.
[8] Baguet J, Pepin J, Hammer L, Levy P, Mallion J. [Cardiovascular consequences of obstructive sleep apnea syndrome]. La Revue de medecine interne/fondee par la Societe nationale francaise de medecine interne. 2003; 24(8): 530-7.
[9] Kokturk O, Ciftci TU, Mollarecep E, Ciftci B. Elevated C-reactive protein levels and increased cardiovascular risk in patients with obstructive sleep apnea syndrome. International Heart Journal. 2005; 46(5): 801-9.
[10] Sharma S, Mishra HK, Sharma H, Goel A, Sreenivas V, Gulati V, et al. Obesity, and not obstructive sleep apnea, is responsible for increased serum hs-CRP levels in patients with sleep-disordered breathing in Delhi. Sleep medicine. 2008; 9(2): 149-56.
[11] Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. Jama. 1999; 282(22): 2131-5.
[12] Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V, et al. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation. 2002; 105(21): 2462-4.
[13] Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation. 1998; 97(5): 425-8.
[14] Sanders MH. Elevated plasma C-reactive protein and increased cardiovascular/cerebrovascular risk in sleep apnea patients. Article reviewed: Elevated C-reactive protein in patients with obstructive sleep apnea (a brief rapid communication). Sleep medicine. 2002; 3(5): 449.
[15] Gozal D, Kheirandish-Gozal L, Bhattacharjee R, Kim J. C-reactive protein and obstructive sleep apnea syndrome in children. Front Biosci (Elite Ed). 2012 Jun 1; 4: 2410-22.
[16] Li AM, Chan MH, Yin J, et al, C-reactive protein in children with obstructive sleep apnea and the effects of treatment. Pediatr Pulmonol. 2008 Jan; 43(1): 34-40.
[17] Teo DT, Mitchell RB. Systematic review of effects of adenotonsillectomy on cardiovascular parameters in children with obstructive sleep apnea.Otolaryngol Head Neck Surg. 2013 Jan; 148(1): 21-8.
[18] Guilleminault C, Kirisoglu C, Ohayon MM. C-reactive protein and sleep-disordered breathing. Sleep. 2004; 27(8): 1507-11.
[19] Zouaoui Boudjeltia K, Van Meerhaeghe A, Doumit S, Guillaume M, Cauchie P, Brohée D, et al. Sleep apnoea-hypopnoea index is an independent predictor of high-sensitivity C-reactive protein elevation. Respiration. 2006; 73(2): 243-6.
[20] Guven SF, Turkkani MH, Ciftci B, Ciftci TU, Erdogan Y. The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep apnea. Sleep and Breathing. 2012; 16(1): 217-21.
[21] Kheirandish-Gozal L, Capdevila OS, Tauman R, Gozal D. Plasma C-reactive protein in nonobese children with obstructive sleep apnea before and after adenotonsillectomy. Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine. 2006; 2(3): 301.
Author Information
  • Health Research Center-Pediatric Department, Baqiyatallah University of Medical Sciences, Tehran, Iran

  • New Hearing Technologies Research Center, ENT Department, Baqiyatallah University of Medical Sciences, Tehran, Iran

  • Students’ Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

  • Students’ Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

Cite This Article
  • APA Style

    Afsharpaiman S, Yosefi J, Shahverdi E, Kazemi H. (2015). Adenotonsillectomy: Effect on CRP Level in Children. American Journal of Clinical and Experimental Medicine, 3(5), 275-278. https://doi.org/10.11648/j.ajcem.20150305.23

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    ACS Style

    Afsharpaiman S; Yosefi J; Shahverdi E; Kazemi H. Adenotonsillectomy: Effect on CRP Level in Children. Am. J. Clin. Exp. Med. 2015, 3(5), 275-278. doi: 10.11648/j.ajcem.20150305.23

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    AMA Style

    Afsharpaiman S, Yosefi J, Shahverdi E, Kazemi H. Adenotonsillectomy: Effect on CRP Level in Children. Am J Clin Exp Med. 2015;3(5):275-278. doi: 10.11648/j.ajcem.20150305.23

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  • @article{10.11648/j.ajcem.20150305.23,
      author = {Afsharpaiman S and Yosefi J and Shahverdi E and Kazemi H},
      title = {Adenotonsillectomy: Effect on CRP Level in Children},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {3},
      number = {5},
      pages = {275-278},
      doi = {10.11648/j.ajcem.20150305.23},
      url = {https://doi.org/10.11648/j.ajcem.20150305.23},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20150305.23},
      abstract = {There is an increased risk of cardiovascular and cerebrovascular events in patients with obstructive sleep apnea (OSA). There are contradictory results about the correlation between serum CRP levels and OSA severity. The purpose of this work was to evaluate CRP level after adenotonsillectomy in children with clinical symptoms, suspected OSA. This cross – sectional study was conducted between 20 March 2012 and 20 November 2014. The study group was composed of 98 children that indicated adenotonsillectomy due to clinical symptom of OSA. CRP were measured before and after surgery. Of total 98 children (52 males and 46 females) with an average age of 8.14 ± 2.6 years, 14(14.3%), 29(29.6%), 44(44.9%), and 11(11.2%) patients were with adenoid grade I, II, III, and IV, respectively and in aspect of tonsil grade, 8(8.2%) with grade I, 37(37.8%) with grade II, 43(43.9%) with grade III, and 10(10.1%) were with grade IV. Comparison of the mean of CRP before and after surgery, based on preoperative adenoid grade showed a significant difference in grade III and IV before and after surgery. In aspect of tonsil grade, in grade I, II and III, the mean CRP before and after surgery showed significant difference too. We found that change of CRP level has relationship with the grade of adenoid and tonsil hypertrophy, and may be helpful marker for indication of adenotonsillectomy.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Adenotonsillectomy: Effect on CRP Level in Children
    AU  - Afsharpaiman S
    AU  - Yosefi J
    AU  - Shahverdi E
    AU  - Kazemi H
    Y1  - 2015/11/18
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    N1  - https://doi.org/10.11648/j.ajcem.20150305.23
    DO  - 10.11648/j.ajcem.20150305.23
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 275
    EP  - 278
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20150305.23
    AB  - There is an increased risk of cardiovascular and cerebrovascular events in patients with obstructive sleep apnea (OSA). There are contradictory results about the correlation between serum CRP levels and OSA severity. The purpose of this work was to evaluate CRP level after adenotonsillectomy in children with clinical symptoms, suspected OSA. This cross – sectional study was conducted between 20 March 2012 and 20 November 2014. The study group was composed of 98 children that indicated adenotonsillectomy due to clinical symptom of OSA. CRP were measured before and after surgery. Of total 98 children (52 males and 46 females) with an average age of 8.14 ± 2.6 years, 14(14.3%), 29(29.6%), 44(44.9%), and 11(11.2%) patients were with adenoid grade I, II, III, and IV, respectively and in aspect of tonsil grade, 8(8.2%) with grade I, 37(37.8%) with grade II, 43(43.9%) with grade III, and 10(10.1%) were with grade IV. Comparison of the mean of CRP before and after surgery, based on preoperative adenoid grade showed a significant difference in grade III and IV before and after surgery. In aspect of tonsil grade, in grade I, II and III, the mean CRP before and after surgery showed significant difference too. We found that change of CRP level has relationship with the grade of adenoid and tonsil hypertrophy, and may be helpful marker for indication of adenotonsillectomy.
    VL  - 3
    IS  - 5
    ER  - 

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