Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 4, July 2016, Pages: 94-97
Received: May 20, 2016; Accepted: May 28, 2016; Published: Jun. 13, 2016
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Authors
Venyce Laurence Agung, Dermatovenereology Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Alwi A. Mappiasse, Dermatovenereology Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Siswanto Wahab, Dermatovenereology Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Gemini Alam, Pharmacy Faculty, Hasanuddin University, Makassar, Indonesia
M. Husni Cangara, Pathological and Anatomy Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Ilhamjaya Patellongi, Biostatistic, Medical Faculty, Hasanuddin University, Makassar, Indonesia
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Abstract
The purpose of this study was to investigate the anti-inflammatory effect of topical aloe vera on COX-2 and histamine expression in mice skin exposed to UVB. COX-2 and histamine expression were examined by using immunochemistry staining in skin samples from totally 20 Swiss Albino mice in the control group, UVB group, UVB+Ethanol group, UVB+Aloe group. The study show topical application of aloe vera with a concentration of 200 mg/kg body weight suppress expression of COX-2 in mice skin exposed to UVB, however it have not been proven to reduce histamine expression. Aloe vera with a dose of 200mg/kg body weight has show anti-inflammatory effects by reduction COX-2 expression that assessed 24 hours after the last treatment.
Keywords
Aloe Vera, Anti-inflammatory, COX-2, Histamine, UVB
To cite this article
Venyce Laurence Agung, Alwi A. Mappiasse, Siswanto Wahab, Gemini Alam, M. Husni Cangara, Ilhamjaya Patellongi, Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB, American Journal of Clinical and Experimental Medicine. Vol. 4, No. 4, 2016, pp. 94-97. doi: 10.11648/j.ajcem.20160404.11
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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