An Assessment of Renal Function Parameters on the Ameliorative Properties of Ginkgo Biloba Extract in Cadmium-Induced Nephrotoxicity in Adult Wistar Rats Model
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 4, July 2016, Pages: 112-117
Received: May 25, 2016; Accepted: Jun. 2, 2016; Published: Jun. 21, 2016
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Ogunnaike Philip Olubunmi, Department of Anatomy, Benjamin Carson [Snr.] School of Medicine, Babcock University, Ilishan-Remo, Nigeria
Olatunji Sunday Yinka, Department of Anatomy, Benjamin Carson [Snr.] School of Medicine, Babcock University, Ilishan-Remo, Nigeria
Owolabi Joshua Oladele, Department of Anatomy, Benjamin Carson [Snr.] School of Medicine, Babcock University, Ilishan-Remo, Nigeria
Fabiyi Adetutu Olubusayo, Department of Anatomy, Benjamin Carson [Snr.] School of Medicine, Babcock University, Ilishan-Remo, Nigeria
Olanrewaju John Afees, Department of Anatomy, Benjamin Carson [Snr.] School of Medicine, Babcock University, Ilishan-Remo, Nigeria
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Renal failure is a growing concern in the modern society and the increasing rate of exposure to toxic substances has contributed a lot to renal diseases. As a result of this, there is a great need for agents that can serve as nephroprotective. The present study assessed some parameters of renal function on the ameliorative properties of Ginkgo biloba extract (GBE) in cadmium (Cd) - induced nephrotoxicity in adult wistar rats model. The study was performed on twenty four (24) male Wistar rats divided into four groups: Group A (Control), Group B (Cd), Group C (Cd + 100mg/kg BW of GBE) and Group D (Cd + 300mg/kg BW of GBE). The Cd and GBE were administered orally through oro-gastric cannula. The results showed changes in the renal function chemical parameters (creatinine, urea, and total protein) in the treated groups compared to the control group. Exposure to Cd lowered the activities of the kidney by increasing the plasma level of creatinine and urea, and decreasing the plasma level of total protein. The creatinine concentration decreased significantly (p<0.05) in groups C and D while the urea concentration increased on GBE administration. A significant decrease was observed in the plasma total protein level in the Cd group when compared with the control and on administration of GBE there was an increase in the plasma total protein concentration in groups C and D. The results showed that Ginkgo biloba treatment ameliorated the effects of Cd-induced nephrotoxicity in all parameters except urea which is to be further investigated. These may be explained by the oxidative and anti-oxidative properties of the Cd and GBE respectively and their mechanisms of action.
Ginkgo Biloba, Nephrotoxicity, Cadmium
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Ogunnaike Philip Olubunmi, Olatunji Sunday Yinka, Owolabi Joshua Oladele, Fabiyi Adetutu Olubusayo, Olanrewaju John Afees, An Assessment of Renal Function Parameters on the Ameliorative Properties of Ginkgo Biloba Extract in Cadmium-Induced Nephrotoxicity in Adult Wistar Rats Model, American Journal of Clinical and Experimental Medicine. Vol. 4, No. 4, 2016, pp. 112-117. doi: 10.11648/j.ajcem.20160404.15
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