Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 5, September 2016, Pages: 118-121
Received: Jun. 7, 2015; Accepted: May 11, 2016; Published: Aug. 3, 2016
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Authors
Asrawati Sofyan, Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Farida Tabri, Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Sri Vitayani Muchtar, Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Idham Jayaganda, Pediatric Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Gemini Alam, Pharmacy Faculty of Hasanuddin University, Makassar, South Sulawesi
Safruddin Amin, Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Anis Anwar Irawan, Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
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Abstract
This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.
Keywords
Adapalene 0.1% Gel, Clinical Manifestations, Mild Acne Vulgaris, Sebum Levels, Tretinoin 0.05% Gel
To cite this article
Asrawati Sofyan, Farida Tabri, Sri Vitayani Muchtar, Idham Jayaganda, Gemini Alam, Safruddin Amin, Anis Anwar Irawan, Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients, American Journal of Clinical and Experimental Medicine. Vol. 4, No. 5, 2016, pp. 118-121. doi: 10.11648/j.ajcem.20160405.11
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