Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris

Muhlis Yunus; Anis Irawan Anwar; Siswanto Wahab; Farida Tabri; Ilhamjaya Patellongi; Johanes Widodo

doi:doi:10.11648/j.ajcem.20170502.11

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Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, Johanes Widodo

Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 2)

Received: 25 January 2017 Accepted: 10 February 2017 Published: 1 March 2017

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Abstract

Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.

Published in	American Journal of Clinical and Experimental Medicine (Volume 5, Issue 2)
DOI	10.11648/j.ajcem.20170502.11
Page(s)	30-35
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Acne Vulgaris, Autologous Serum, Doxycycline, Estradiol

References

[1]	Suh, D. H et al. A Multicenter Epidemiological Study Of Acne Vulgaris In Korea. International Society of Dermatology. 2011. 50: 673-81.
[2]	Anwar A I. Procedures for Acne Vulgaris. Makassar. Two One Pree. 2013.
[3]	Seth V & Mishra A. Acne Vulgaris Management; what's new and what's still true ?. Int J Adv Med. 2015: 2 (1): 1-5.
[4]	Gamble et al. Topical Antimicrobial Treatment of Acne Vulgaris. Am. J Clin Dermatol. 2012. 13: 141-62.
[5]	Hanafi M J. Haid dan Siklusnya, In: Wiknjosastro, H., Saifuddin, AB & Rachimhadhi, T. (Eds.) Science Content Tridasa Printer, Jakarta: YayasanBima. Pustaka Sarwono Prawirohardji 2007.
[6]	Elsaie M L. Hormonal Treatment of Acne Vulgaris; An Update. Clinical, Cosmetic and Investigational Dermatology. 2016. 9: 241-48.
[7]	Bakry O A & Shazly. Role Of Hormones And Blood Lipids In The Pathogenesis Of Acne Vulgaris In Non-Obese, Non-Hirsute Females. Indian Dermatology Online Journal. 2014. 5 (1): 9-16.
[8]	Kong Y L &Tey H L. Treatment of Acne Vulgaris During Pregnancy and Lactation. Drugs. 2013. 73: 779-87.
[9]	Meredith F M & Ormerod A D. The Management of Acne Vulgaris in Pregnancy. Am. J Clin Dermatol. 2013. 14: 351-58.
[10]	Fox C & Gerber. Treatment Modalities for Acne. Molecule. 2016. 21: 1-20.
[11]	Aydemir E H. Acne Vulgaris. Turk Ped Ars. 2014. 49: 13-6.
[12]	Dawson A L & Dellavalle R P. Acne Vulgaris. BMJ. 2013. 1-7.
[13]	Tahir M. Pathogenesis of Acne Vulgaris; Simplified. Journal of Pakistan Association of Dermatologists. 2010. 20: 93-97.
[14]	Czop B B. The Aetiopathogenesis Of Acne Vulgaris - What's New ?. International Journal of Cosmetic Science. 2014. 36: 187-194.
[15]	Malahlela P & Motswaledi M H. Management of Mild to Moderate Acne Vulgaris. S Afr Fam Pract. 2013. 55 (3): 241-44.
[16]	Lai K W & Mercurio M G. Update on the Treatment of Acne Vulgaris. JCOM. 2009. 16 (3): 116-26.
[17]	Whitney M & Ditre C. Management Strategies for Acne Vulgaris. Clinical, Cosmetic and Investigational Dermatology. 2011. 4: 41-53.
[18]	Kogawa A C & Salgado H R N. Doxycycline Hyclate: A Review Of Properties, Applications And Analytical Methods. Pharmaceutical analysis. 2012. 2 (4): 11-25.
[19]	Simonart T. Newer Approaches to the Treatment of Acne Vulgaris. Clin Am. J Dermatol. 2012. 13 (6): 357-64.
[20]	Werner M. A Systematic Review of the Effects and Side Effects of Treatment with Oral Tetracycline in Acne Vulgaris. Master Thesis in Medicine. 2013.
[21]	Davis E C & Callender. A Review of Acne in Ethnic Skin Pathogenesis, Clinical manifestations, and Management Strategies. Aesthetic J Clin Dermatol. 2010. 3 (4): 24-38.
[22]	Elahmed H H. Management of Acne Vulgaris with Hormonal Therapies in Adult Female Patients. Dermatology Therapy. 2015. 4: 166-72.
[23]	Shu Y Y & Maibach H I. Estrogen and Skin. Am. J Clin Dermatol. 2011. 12 (5): 297 -311.
[24]	Gumanga S K & Arye R A K. Menstrual Some Characteristics In Adolescent Girls In Accra, Ghana. Ghana Medical Journal. 2012. 46 (1): 3-7.
[25]	Edison N et al. Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients. American Journal of Clinical and Experimental Medicine. 2016. 4 (6): 170-78.
[26]	Ilham. Pengujian tetes serum autolog sebagai antibakteri dan inflamasi pada penyakit permukaan okuler. Makassar, Universitas Hasanuddin. 2011.

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APA Style

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. (2017). Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. American Journal of Clinical and Experimental Medicine, 5(2), 30-35. https://doi.org/10.11648/j.ajcem.20170502.11

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ACS Style

Muhlis Yunus; Anis Irawan Anwar; Siswanto Wahab; Farida Tabri; Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am. J. Clin. Exp. Med. 2017, 5(2), 30-35. doi: 10.11648/j.ajcem.20170502.11

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AMA Style

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am J Clin Exp Med. 2017;5(2):30-35. doi: 10.11648/j.ajcem.20170502.11

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@article{10.11648/j.ajcem.20170502.11,
  author = {Muhlis Yunus and Anis Irawan Anwar and Siswanto Wahab and Farida Tabri and Ilhamjaya Patellongi and Johanes Widodo},
  title = {Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {2},
  pages = {30-35},
  doi = {10.11648/j.ajcem.20170502.11},
  url = {https://doi.org/10.11648/j.ajcem.20170502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170502.11},
  abstract = {Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.},
 year = {2017}
}

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TY  - JOUR
T1  - Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris
AU  - Muhlis Yunus
AU  - Anis Irawan Anwar
AU  - Siswanto Wahab
AU  - Farida Tabri
AU  - Ilhamjaya Patellongi
AU  - Johanes Widodo
Y1  - 2017/03/01
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170502.11
DO  - 10.11648/j.ajcem.20170502.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 30
EP  - 35
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170502.11
AB  - Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.
VL  - 5
IS  - 2
ER  -

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Author Information

Muhlis Yunus

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Anis Irawan Anwar

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Siswanto Wahab

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Farida Tabri

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Ilhamjaya Patellongi

Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Johanes Widodo

Department of Dermatology and Venereology, Medical Faculty, Gadjah Mada University, Jogjakarta, Indonesia

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APA Style

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. (2017). Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. American Journal of Clinical and Experimental Medicine, 5(2), 30-35. https://doi.org/10.11648/j.ajcem.20170502.11

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ACS Style

Muhlis Yunus; Anis Irawan Anwar; Siswanto Wahab; Farida Tabri; Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am. J. Clin. Exp. Med. 2017, 5(2), 30-35. doi: 10.11648/j.ajcem.20170502.11

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AMA Style

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am J Clin Exp Med. 2017;5(2):30-35. doi: 10.11648/j.ajcem.20170502.11

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@article{10.11648/j.ajcem.20170502.11,
  author = {Muhlis Yunus and Anis Irawan Anwar and Siswanto Wahab and Farida Tabri and Ilhamjaya Patellongi and Johanes Widodo},
  title = {Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {2},
  pages = {30-35},
  doi = {10.11648/j.ajcem.20170502.11},
  url = {https://doi.org/10.11648/j.ajcem.20170502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170502.11},
  abstract = {Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris
AU  - Muhlis Yunus
AU  - Anis Irawan Anwar
AU  - Siswanto Wahab
AU  - Farida Tabri
AU  - Ilhamjaya Patellongi
AU  - Johanes Widodo
Y1  - 2017/03/01
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170502.11
DO  - 10.11648/j.ajcem.20170502.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 30
EP  - 35
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170502.11
AB  - Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.
VL  - 5
IS  - 2
ER  -

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