The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction
American Journal of Clinical and Experimental Medicine
Volume 5, Issue 4, July 2017, Pages: 108-114
Received: May 19, 2017;
Published: Jun. 6, 2017
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Hou Zhenjiang, Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Mu Zhaoxin, Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Zhang Jingyu, Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Fan Hong, Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Hou Jianzhang, Department of Surgery, Cangzhou People's Hospital, Cangzhou Medical College, Cangzhou, China
This thesis aims to discuss the correlation of blood lipid and its ratio, Cystatin C(CysC) and Homocysteine (Hcy) of thyroid dysfunction patients, who are hyperthyroidism, subclinical hyperthyroidism, hypothyroidism and subclinical hypothyroidism. The authors choose each 60 patients of four groups of thyroid dysfunction and the control group to measure the serum TH, blood lipid, CysC and Hcy and calculate and analyze blood lipid ratio. As a result, on the one hand, TC, TG, LDL-C of hyperthyroidism and subclinical hyperthyroidism group are obviously lower than the control group, TC/HDL-C and TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C of hyperthyroidism are significantly lower than the hyperthyroidism and the control group. LDL-C/HDL-C, and TC/HDL-C and TG/HDL-C of subclinical hyperthyroidism significantly reduce, and especially LCI is significant. The followings are LDL-C/HDL-C, nevertheless TC/HDL-C, TG/HDL-C are higher than the control group. On the other hand, TC, TG, LDL-C, TG/HDL-C, LDL-C/ HDL-C, LCI and non-HDL-C of hypothyroidism are prominently higher than the subclinical hypothyroidism and the control group. TC, TG and LDL-C, LDL-C/HDL-C and non-HDL-C of the subclinical hypothyroidism are higher than the control group. HDL-C is lower than the control group. TC has the highest relevance in various kinds of TH and the followings are respectively: non-HDL-C, LDL-C and LCI. CysC of hyperthyroidism and subclinical hyperthyroidism group obviously increases, whereas Hcy decreases. CysC of hypothyroidism and subclinical hypothyroidism group obviously decreases, whereas Hcy increases. According to the results, the authors come to the conclusion that the change of blood lipid ratio of subclinical thyroid dysfunction is more obvious than the index of single blood lipid and the CysC and Hcy also corresponding change. Dynamic monitoring TSH, blood lipid ratio, CysC and Hcy has an important value of transforming from subclinical thyroid dysfunction to clinical dysfunction and prediction of concurrent CVD. Joint detection is expected to become the ideal optimization combination of project.
The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction, American Journal of Clinical and Experimental Medicine.
Vol. 5, No. 4,
2017, pp. 108-114.
Han Q, Huang HL. Advances in research of influencing factors of thyroid diseases [J]. Chin Occup Med, 2015, vol. 42, pp. 345-347.
Matano F, Murai Y, Adachi K, et al. Pathophysiology and management of intracranial arterial stenosis around the circle of Willis associated with hyperthyroidism: case reports and literature review [J]. N, 2014, vol. 37, pp. 347-356.
Yang W, Xian P, Liu P, et al. Coexistence of moyamoya and Graves diseases: the clinical characteristics and treatment effects of 21 Chinese patients [J]. Clin Neurol Neurosurg [J]. 2013, vol. 115, pp. 1647-1652.
Ryödi E, Salmi J, Jaatinen P, et al. Cardiovascular morbidity and mortality in surgically treated hyperthyroidism - a nation-wide cohort study with a long-term follow-up. [J]. Clinical Eedoerinolong, 2014,vol. 80,pp.743-750
Wiles KS, Jarvis S, Nelson-Piercy C. Are we overtreating subclinical hypothyroidism? [J]. BMJ, 2015, vol. 351, pp. h4726.
Abulaiti Alimujiang, Li B, Zhang L, et al. Relationship between subclinical hypothyroidism and coronary artery disease [J]. Medical Journal of the Chinese People’s Armed Police Force, 2016, vol. 27, pp. 221-224.
Kamasaki H, Takeuchi T, Mikami T, et al. A case of graves’disease diagnosed in the course of bilateral carotid artery stenosis (moyamoya disease); a case report and review of the literature [J]. Clin Pediatr Endocrinol, 2013, vol. 22, pp. 39-44.
Hou ZJ, Hou JZ, Wang FL. Progress of Thyroid Diseases and Cardiovascular Disease Research [J]. Medical Recapitulate, 2015, vol. 21, pp. 4296-4298.
ZHou CJ, ZHu XL, Wang CG, et al. The diagnosis value of combined detection of TH and Hcy levels for patients with hypothyroidism [J]. Chin J Health Lab Tec, 2016, vol. 26, pp. 2205-2207.
CHang Yu-ying, Sun Yu-qia. The relationship between serum resistin level and blood sugar, blood Hpids and thyroid hormone in patients with Hyperthyroidism [J]. Chinese Journal of Endemiology, 2011, vol. 30, pp. 559-562.
Selim FO, Ahmed AM. The association between serum paraxonase-1 activity, thyroid hormones and lipids profile in patients with primary hyperthyroidism [J]. Int J Adv Res, 2014, vol. 2, pp. 172-181.
Wang Y, Ruan HL, Li Yi, et al. Changes of thyroid function, autoantibodies, bone mineral density and bone metabolism indexes in patients with hyperthyroidism [J]. Journal of Hainan Medical University, 2016, vol. 22, pp. 1418-1420.
Xiao L, Guo M, Fan RY. Study on the Relationship between Serum Lipid Metabolism and Thyroid Hormone Levels in Patients with hyperthyroidism [J]. Chin J Lab Diagn, 2016, vol. 20, pp. 1679-1681.
Sun JH, ZHang Y, Lu HR, et al. Correlation of serum adiponectin with thyroid dysfunction in elderly people [J]. Lab Med, 2016, vol. 31, pp. 549-552.
Gu Q, Shao KK, Wang YX. Analysis of serum lipids and serum protein levels in patients with abnormal thyroid function [J]. Lab Med Clin, 2014, vol. 11, pp. 3455-3456.
Yuan ZC, Yan HY. Correlation of thyroid function and blood lipids [J]. Jiangsu Med, 2013, vol. 39, pp. 949-950.
Zhang ZZ, Zhang HM, Fu XL. The relationship of the levels of FT3, FT4, TSH and atherosclerosis related factors of patients with hyperthyroidism [J]. Chin J Diffie and Compl Cas, 2016, vol. 15, pp. 926-930.
ZHao JJ, Yang LB. Hypothyroidism and dyslipidemia [J]. Chinese Journal of Practical Internal Medicine, 2014, vol. 34, pp. 340-343.
Garduno-Garcia Jde J, Alvirde-Garcia U, Lopez-Carrasco G, et al. TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects [J]. Eur J Endocrinol, 2010, vol. 163, pp. 273-278.
Fu YL, Fa LM. Research Progress on the relationship between thyroid function and metabolic syndrome [J]. J Mod Med Health January, 2017, vol. 33, pp. 77-79.
Li F. Determination and clinical significance of subclinical hypothyroidism in patients with serum homocysteine and blood lipids [J]. Zhejiang Practical Med, 2009, vol. 14, pp. 366-367.
Song QZ, Xu FL, Bi XP, et al. Clinical significance of serum homocysteine and lipids determination in hypothyroidism[J]. Lab Med, 2007, vol. 22, pp. 176-178.
Toruner F, Altinova AE, Karakoc A, et al. Risk factorsfor cardiovascu1ar disease in patients with subclinical hypothyroidism [J]. Adv Ther, 2008, vol. 25, pp. 430-437.
LópezRubio MA, TárragaLópez PJ, Rodríguez Montes JA, et al. Subclinical hypothyroidism and cardiovascular risk [J]. Nutr Hosp, 2015, vol. 31, pp. 2095-2102.
Van Tienhoven-Wind LJ, Dullaart RP. Low-normal thyroid function and the pathogenesis of commoncardiometa-bolic disorders [J]. EurJClin Invest, 2015, vol. 45, pp.494-503.
Karthick N, Dillara K, Poornima KN, et al. Dyslipidaemic changes in women with subclinical hypothyroidism [J]. J Clin Diagn Res, 2013, vol. 7, pp. 2122-2125.
Laway BA, War FA, Shah S, et al. Alteration of lipid parameters in patients with subclinical hypothyroidism [J]. Int J Endocrinol Metab, 2014, vol. 12, pp. e17496.
Díez JJ, Iglesias P.Serum cholesterol and triglyceride concentrations in diabetic patients with subclinical hypothyroidism [J]. Endocrinol Nutr, 2014, vol. 61, pp. 419-425.
Wang C, Zhang P. Clinical research progress of lipid ratio in predicting cardiovascular disease [J]. Shandong Medical Journal, 2015, vol. 55, pp. 99-102.
Huang X, Cui ZW, Wu W, et al. Application of blood lipid ratio in risk assessment of cardiovascular and cerebrovascular diseases [J]. International Journal of Laboratory Medicine, 2015, vol. 36, pp. 1274-1276.
Xie YJ. The level and significance of serum lipids in patients with different types of coronary heart disease [J]. Contemporary Medicine, 2012, vol. 18, pp. 10-11.
Simprini LA, Villines TC, Rich M, et al. The relationship between subclinical atherosclerosis, non-high-density lipoprotein cholesterol, exercise and diet among male participants of the PACC project [J]. J Clin Lipidol, 2012, vol. 6, pp. 174-179.
Chen XJ, Huang ZH. Non high density lipoprotein cholesterol in coronary atherosclerotic heart disease the value of predictive and prognostic assessment [J]. China Medical Engineering, 2016, vol. 24, pp. 53-55.
Ye Y, Gai X, Xie H, et al. Impact of thyroid function on senlm cystatin C and estimated glomerular filtration rate: a cross-sectional study [J]. Endocr Pract, 2013, vol. 19, pp. 397-403.
Xu YQ. Application of serum cystatin C, creatinine and beta 2- in the detection of thyroid dysfunction [J]. J Med Theor & Prac, 2015, vol. 28, pp. 953-954.
Yu Wei-guo, Liu Zheng, Zhang Dong-feng, et al. Meta-analysis of relationship between serum cystatin C Levels and Thyroid function [J]. labeled immunoassay and clinic, 2016, 2 vol. 3, pp. 579-582, 589.
Schmid C, Ghirlanda-Keller C, Zwimpfer C, et al. Triiodothyronine stimulates cystatin C production in bone cells [J]. Biochem Biophys Res Commun, 2012, vol. 419, pp. 425-430.
Wang F, Pan W, Wang H, et al. The impacts of thyroid function on the diagnostic accuracy of cystatin C to detect acute kidney injury in ICU patients: a prospective, observational study [J], Crit Care, 2014, vol. 18, pp. R9.
Fricker M, Wiesli P, Brändle M, et al. Impact of thyroid dysfunction on serum cystatin C[J]. Kidney Int, 2003, vol. 63, pp. 1944-1947.
Zhang D, Wang CG. Research progress in clinical application of cystatin C in coronary heart disease [J]. Med J West China Januar 2014, vol. 26, pp. 127-128,131.
Jiang Xiao-jing, Chen Xin-yun, Chen Hang, et al. Effect of serum cystatin C on status of coronary atherosclerotic plaques [J]. Practical Journal of Clinical Medicine, 2016, vol. 13, pp. 99-101.
Guan Shi-kui, Liu Zheng, Zhang Fa-sheng, et al. A Meta-analysis on Relationship Between Serum Cystatin C Level and Coronary Heart Disease [J]. Labeled immunoassay and clinic 2015, vol. 22, pp. 994-997.
Wu ZR, Zhang LR, Pan YQ. Changes and clinical significance of serum homocysteine and lipids in Patients with primary hypothyroidism and hyperthyroid [J]. Progress in Modern Biomedicine, 2009, vol. 9, pp. 4276-4278.
Yu WZ, Yuan D, Fan YX, et al. Correlation analysis of serum lipids, homocysteine and serum uric acid in patients with subclinical hypothyroidism [J]. Chinese J Lab diagnosis, 2015, vol. 19, pp.1496-1497.
Xiong L, Luo CD, Liu YB, et al. Changes of Plasma Homocysteine and Peripheric Arterial Stiffness in Patients with Subclinical Hypothyroidism [J]. West China Medical Journal, 2015, vol. 30, pp. 2205-2207.
Zhou Y, Chen Y, Cao X. Association between plasma homocysteine status and hypothyroidism: a meta- analysis [J]. Int J Clin ExpMed, 2014, vol. 7, pp. 4544-4553.