A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats
American Journal of Clinical and Experimental Medicine
Volume 5, Issue 4, July 2017, Pages: 145-150
Received: Jun. 10, 2017; Accepted: Jun. 19, 2017; Published: Jul. 17, 2017
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Elham Serki, Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
Mina Hemmati, Birjand Cardiovascular Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
Alireza Pourtalebi-Firoozabadi, Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran; Department of Cellular and Molecular Medicine, Mehrvarzan-e-Saba Gostar Medical Rehabilitation and Maintenance Center of Chronic Mental Patients, Karaj, Iran
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Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicin-induced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of drug-induced liver injury.
Green Tea, White Tea, Rifampin, Chronic Hepatotoxicity
To cite this article
Elham Serki, Mina Hemmati, Alireza Pourtalebi-Firoozabadi, A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats, American Journal of Clinical and Experimental Medicine. Vol. 5, No. 4, 2017, pp. 145-150. doi: 10.11648/j.ajcem.20170504.17
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