American Journal of Clinical and Experimental Medicine

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A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Received: 10 June 2017    Accepted: 19 June 2017    Published: 17 July 2017
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Abstract

Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicin-induced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of drug-induced liver injury.

DOI 10.11648/j.ajcem.20170504.17
Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 4, July 2017)
Page(s) 145-150
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Green Tea, White Tea, Rifampin, Chronic Hepatotoxicity

References
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Author Information
  • Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

  • Birjand Cardiovascular Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran

  • Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran; Department of Cellular and Molecular Medicine, Mehrvarzan-e-Saba Gostar Medical Rehabilitation and Maintenance Center of Chronic Mental Patients, Karaj, Iran

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    Elham Serki, Mina Hemmati, Alireza Pourtalebi-Firoozabadi. (2017). A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats. American Journal of Clinical and Experimental Medicine, 5(4), 145-150. https://doi.org/10.11648/j.ajcem.20170504.17

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    ACS Style

    Elham Serki; Mina Hemmati; Alireza Pourtalebi-Firoozabadi. A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats. Am. J. Clin. Exp. Med. 2017, 5(4), 145-150. doi: 10.11648/j.ajcem.20170504.17

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    AMA Style

    Elham Serki, Mina Hemmati, Alireza Pourtalebi-Firoozabadi. A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats. Am J Clin Exp Med. 2017;5(4):145-150. doi: 10.11648/j.ajcem.20170504.17

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  • @article{10.11648/j.ajcem.20170504.17,
      author = {Elham Serki and Mina Hemmati and Alireza Pourtalebi-Firoozabadi},
      title = {A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {5},
      number = {4},
      pages = {145-150},
      doi = {10.11648/j.ajcem.20170504.17},
      url = {https://doi.org/10.11648/j.ajcem.20170504.17},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20170504.17},
      abstract = {Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicin-induced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of drug-induced liver injury.},
     year = {2017}
    }
    

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    T1  - A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats
    AU  - Elham Serki
    AU  - Mina Hemmati
    AU  - Alireza Pourtalebi-Firoozabadi
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    DO  - 10.11648/j.ajcem.20170504.17
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
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    EP  - 150
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20170504.17
    AB  - Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicin-induced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of drug-induced liver injury.
    VL  - 5
    IS  - 4
    ER  - 

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