Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement

Mohamed Masoud; Catherine Xie; Jessica Zhou; Xia Chen; Ming Xie

doi:doi:10.11648/j.ajcem.20180601.14

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Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement

Mohamed Masoud, Catherine Xie, Jessica Zhou, Xia Chen, Ming Xie

Published in American Journal of Clinical and Experimental Medicine (Volume 6, Issue 1)

Received: 11 December 2017 Accepted: 10 January 2018 Published: 29 January 2018

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Abstract

Peripheral T cell lymphomas (PTCLs) are uncommon and less well studied. Most PTCLs present as systemic disease and often involve bone marrow. Bone marrow involvement by PTCLs may damage the normal hematopoiesis and bring more challenge to clinical management of these patients. This study focuses on the clinical pathological features and clinical outcomes in 13 patients with nodal peripheral T cell lymphoma and subsequent bone marrow biopsy positive for the same lymphoma. Eight patients were diagnosed of peripheral T cell lymphoma - not otherwise specified (PTCL-NOS), 3 angioimmunoblastic T cell lymphoma (AITL), 1 anaplastic large cell lymphoma (ALCL), and 1 T cell lymphoma of gamma-delta origin (TCL-gamma/delta). All patients had peripheral blood abnormalities: 11 anemia, 7 thrombocytopenia, 5 neutropenia, and 2 lymphocytosis. Of interest, the CD4/CD8 phenotype of PTCL was shown correlating with abnormal peripheral blood findings: CD4+/CD8- phenotype was more often associated with anemia and thrombocytopenia, and CD4-/CD8+ phenotype was associated with lymphocytosis. Chemotherapy remains the choice of first line treatment for these patients with or without stem cell transplantation. 12 patients had treatment and follow up data available for review, 5 were in remission or free of disease during the follow up period; 5 patients were alive or in hospice with persistent disease and 2 died of disease due to multiple complications. The outcome of PTCL treated with the standard chemotherapy has been less favorable compared with B cell lymphomas. Majority of the patients with nodal PTCL have bone marrow involvement at the time of initial diagnosis, which has significant impact on normal hematopoiesis and may be a significant factor in the overall unfavorable prognosis for these patients. Further investigation with better knowledge about this disease will be helpful in the development of more efficient therapy and improve the disease free survival and life quality for these patients.

Published in	American Journal of Clinical and Experimental Medicine (Volume 6, Issue 1)
DOI	10.11648/j.ajcem.20180601.14
Page(s)	22-26
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Peripheral T Cell Lymphoma, Bone Marrow Biopsy, Anemia, Thrombocytopenia, Lymphocytosis

References

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APA Style

Mohamed Masoud, Catherine Xie, Jessica Zhou, Xia Chen, Ming Xie. (2018). Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement. American Journal of Clinical and Experimental Medicine, 6(1), 22-26. https://doi.org/10.11648/j.ajcem.20180601.14

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ACS Style

Mohamed Masoud; Catherine Xie; Jessica Zhou; Xia Chen; Ming Xie. Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement. Am. J. Clin. Exp. Med. 2018, 6(1), 22-26. doi: 10.11648/j.ajcem.20180601.14

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AMA Style

Mohamed Masoud, Catherine Xie, Jessica Zhou, Xia Chen, Ming Xie. Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement. Am J Clin Exp Med. 2018;6(1):22-26. doi: 10.11648/j.ajcem.20180601.14

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@article{10.11648/j.ajcem.20180601.14,
  author = {Mohamed Masoud and Catherine Xie and Jessica Zhou and Xia Chen and Ming Xie},
  title = {Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {6},
  number = {1},
  pages = {22-26},
  doi = {10.11648/j.ajcem.20180601.14},
  url = {https://doi.org/10.11648/j.ajcem.20180601.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20180601.14},
  abstract = {Peripheral T cell lymphomas (PTCLs) are uncommon and less well studied. Most PTCLs present as systemic disease and often involve bone marrow. Bone marrow involvement by PTCLs may damage the normal hematopoiesis and bring more challenge to clinical management of these patients. This study focuses on the clinical pathological features and clinical outcomes in 13 patients with nodal peripheral T cell lymphoma and subsequent bone marrow biopsy positive for the same lymphoma. Eight patients were diagnosed of peripheral T cell lymphoma - not otherwise specified (PTCL-NOS), 3 angioimmunoblastic T cell lymphoma (AITL), 1 anaplastic large cell lymphoma (ALCL), and 1 T cell lymphoma of gamma-delta origin (TCL-gamma/delta). All patients had peripheral blood abnormalities: 11 anemia, 7 thrombocytopenia, 5 neutropenia, and 2 lymphocytosis. Of interest, the CD4/CD8 phenotype of PTCL was shown correlating with abnormal peripheral blood findings: CD4+/CD8- phenotype was more often associated with anemia and thrombocytopenia, and CD4-/CD8+ phenotype was associated with lymphocytosis. Chemotherapy remains the choice of first line treatment for these patients with or without stem cell transplantation. 12 patients had treatment and follow up data available for review, 5 were in remission or free of disease during the follow up period; 5 patients were alive or in hospice with persistent disease and 2 died of disease due to multiple complications. The outcome of PTCL treated with the standard chemotherapy has been less favorable compared with B cell lymphomas. Majority of the patients with nodal PTCL have bone marrow involvement at the time of initial diagnosis, which has significant impact on normal hematopoiesis and may be a significant factor in the overall unfavorable prognosis for these patients. Further investigation with better knowledge about this disease will be helpful in the development of more efficient therapy and improve the disease free survival and life quality for these patients.},
 year = {2018}
}

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TY  - JOUR
T1  - Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement
AU  - Mohamed Masoud
AU  - Catherine Xie
AU  - Jessica Zhou
AU  - Xia Chen
AU  - Ming Xie
Y1  - 2018/01/29
PY  - 2018
N1  - https://doi.org/10.11648/j.ajcem.20180601.14
DO  - 10.11648/j.ajcem.20180601.14
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 22
EP  - 26
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20180601.14
AB  - Peripheral T cell lymphomas (PTCLs) are uncommon and less well studied. Most PTCLs present as systemic disease and often involve bone marrow. Bone marrow involvement by PTCLs may damage the normal hematopoiesis and bring more challenge to clinical management of these patients. This study focuses on the clinical pathological features and clinical outcomes in 13 patients with nodal peripheral T cell lymphoma and subsequent bone marrow biopsy positive for the same lymphoma. Eight patients were diagnosed of peripheral T cell lymphoma - not otherwise specified (PTCL-NOS), 3 angioimmunoblastic T cell lymphoma (AITL), 1 anaplastic large cell lymphoma (ALCL), and 1 T cell lymphoma of gamma-delta origin (TCL-gamma/delta). All patients had peripheral blood abnormalities: 11 anemia, 7 thrombocytopenia, 5 neutropenia, and 2 lymphocytosis. Of interest, the CD4/CD8 phenotype of PTCL was shown correlating with abnormal peripheral blood findings: CD4+/CD8- phenotype was more often associated with anemia and thrombocytopenia, and CD4-/CD8+ phenotype was associated with lymphocytosis. Chemotherapy remains the choice of first line treatment for these patients with or without stem cell transplantation. 12 patients had treatment and follow up data available for review, 5 were in remission or free of disease during the follow up period; 5 patients were alive or in hospice with persistent disease and 2 died of disease due to multiple complications. The outcome of PTCL treated with the standard chemotherapy has been less favorable compared with B cell lymphomas. Majority of the patients with nodal PTCL have bone marrow involvement at the time of initial diagnosis, which has significant impact on normal hematopoiesis and may be a significant factor in the overall unfavorable prognosis for these patients. Further investigation with better knowledge about this disease will be helpful in the development of more efficient therapy and improve the disease free survival and life quality for these patients.
VL  - 6
IS  - 1
ER  -

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Author Information

Mohamed Masoud

Department of Pathology, Oakland University William Beaumont School of Medicine, Troy, USA
Catherine Xie

Department of Pathology, Oakland University William Beaumont School of Medicine, Troy, USA
Jessica Zhou

Department of Pathology, Oakland University William Beaumont School of Medicine, Troy, USA
Xia Chen

Department of Pathology, Oakland University William Beaumont School of Medicine, Troy, USA
Ming Xie

Department of Pathology, Oakland University William Beaumont School of Medicine, Troy, USA

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APA Style

Mohamed Masoud, Catherine Xie, Jessica Zhou, Xia Chen, Ming Xie. (2018). Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement. American Journal of Clinical and Experimental Medicine, 6(1), 22-26. https://doi.org/10.11648/j.ajcem.20180601.14

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ACS Style

Mohamed Masoud; Catherine Xie; Jessica Zhou; Xia Chen; Ming Xie. Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement. Am. J. Clin. Exp. Med. 2018, 6(1), 22-26. doi: 10.11648/j.ajcem.20180601.14

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AMA Style

Mohamed Masoud, Catherine Xie, Jessica Zhou, Xia Chen, Ming Xie. Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement. Am J Clin Exp Med. 2018;6(1):22-26. doi: 10.11648/j.ajcem.20180601.14

Copy | Download

@article{10.11648/j.ajcem.20180601.14,
  author = {Mohamed Masoud and Catherine Xie and Jessica Zhou and Xia Chen and Ming Xie},
  title = {Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {6},
  number = {1},
  pages = {22-26},
  doi = {10.11648/j.ajcem.20180601.14},
  url = {https://doi.org/10.11648/j.ajcem.20180601.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20180601.14},
  abstract = {Peripheral T cell lymphomas (PTCLs) are uncommon and less well studied. Most PTCLs present as systemic disease and often involve bone marrow. Bone marrow involvement by PTCLs may damage the normal hematopoiesis and bring more challenge to clinical management of these patients. This study focuses on the clinical pathological features and clinical outcomes in 13 patients with nodal peripheral T cell lymphoma and subsequent bone marrow biopsy positive for the same lymphoma. Eight patients were diagnosed of peripheral T cell lymphoma - not otherwise specified (PTCL-NOS), 3 angioimmunoblastic T cell lymphoma (AITL), 1 anaplastic large cell lymphoma (ALCL), and 1 T cell lymphoma of gamma-delta origin (TCL-gamma/delta). All patients had peripheral blood abnormalities: 11 anemia, 7 thrombocytopenia, 5 neutropenia, and 2 lymphocytosis. Of interest, the CD4/CD8 phenotype of PTCL was shown correlating with abnormal peripheral blood findings: CD4+/CD8- phenotype was more often associated with anemia and thrombocytopenia, and CD4-/CD8+ phenotype was associated with lymphocytosis. Chemotherapy remains the choice of first line treatment for these patients with or without stem cell transplantation. 12 patients had treatment and follow up data available for review, 5 were in remission or free of disease during the follow up period; 5 patients were alive or in hospice with persistent disease and 2 died of disease due to multiple complications. The outcome of PTCL treated with the standard chemotherapy has been less favorable compared with B cell lymphomas. Majority of the patients with nodal PTCL have bone marrow involvement at the time of initial diagnosis, which has significant impact on normal hematopoiesis and may be a significant factor in the overall unfavorable prognosis for these patients. Further investigation with better knowledge about this disease will be helpful in the development of more efficient therapy and improve the disease free survival and life quality for these patients.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Clinical Pathological Features of Peripheral T Cell Lymphoma with Concurrent Bone Marrow Involvement
AU  - Mohamed Masoud
AU  - Catherine Xie
AU  - Jessica Zhou
AU  - Xia Chen
AU  - Ming Xie
Y1  - 2018/01/29
PY  - 2018
N1  - https://doi.org/10.11648/j.ajcem.20180601.14
DO  - 10.11648/j.ajcem.20180601.14
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 22
EP  - 26
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20180601.14
AB  - Peripheral T cell lymphomas (PTCLs) are uncommon and less well studied. Most PTCLs present as systemic disease and often involve bone marrow. Bone marrow involvement by PTCLs may damage the normal hematopoiesis and bring more challenge to clinical management of these patients. This study focuses on the clinical pathological features and clinical outcomes in 13 patients with nodal peripheral T cell lymphoma and subsequent bone marrow biopsy positive for the same lymphoma. Eight patients were diagnosed of peripheral T cell lymphoma - not otherwise specified (PTCL-NOS), 3 angioimmunoblastic T cell lymphoma (AITL), 1 anaplastic large cell lymphoma (ALCL), and 1 T cell lymphoma of gamma-delta origin (TCL-gamma/delta). All patients had peripheral blood abnormalities: 11 anemia, 7 thrombocytopenia, 5 neutropenia, and 2 lymphocytosis. Of interest, the CD4/CD8 phenotype of PTCL was shown correlating with abnormal peripheral blood findings: CD4+/CD8- phenotype was more often associated with anemia and thrombocytopenia, and CD4-/CD8+ phenotype was associated with lymphocytosis. Chemotherapy remains the choice of first line treatment for these patients with or without stem cell transplantation. 12 patients had treatment and follow up data available for review, 5 were in remission or free of disease during the follow up period; 5 patients were alive or in hospice with persistent disease and 2 died of disease due to multiple complications. The outcome of PTCL treated with the standard chemotherapy has been less favorable compared with B cell lymphomas. Majority of the patients with nodal PTCL have bone marrow involvement at the time of initial diagnosis, which has significant impact on normal hematopoiesis and may be a significant factor in the overall unfavorable prognosis for these patients. Further investigation with better knowledge about this disease will be helpful in the development of more efficient therapy and improve the disease free survival and life quality for these patients.
VL  - 6
IS  - 1
ER  -

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