Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease

Elena López-Ramiro; Mercedes Rubert; Emilio González-Parra; Ignacio Mahillo; Concepción de la Piedra

doi:doi:10.11648/j.ajcem.20170504.18

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Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease

Elena López-Ramiro, Mercedes Rubert, Emilio González-Parra, Ignacio Mahillo, Concepción de la Piedra

Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 4)

Received: 16 May 2017 Accepted: 27 May 2017 Published: 18 July 2017

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Abstract

Introduction: Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis. Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD). Patients and methods: One hundred and forty-five patients with stage-5 CKD were studied (mean age 65.9 ± 14.6 years; 74 males and 71 females; Levels of 25(OH)D, age, bone alkaline phosphatase, procollagen I amino-terminal propeptide, carboxyterminal telopeptide of collagen I, intact parathyroid hormone (PTH), bio-PTH, hemoglobin, hematocrit, urea, creatinine, total proteins, albumin, iron, iron saturation index, calcium, phosphorous, total alkaline phosphatase, serum CO₂, cholesterol, triglycerides, C-reactive protein, prealbumin, ferritin, proBNP, and fibroblast growth factor-23 (FGF-23) were determined. Spearman’s correlation coefficient and p values were analyzed. Results: This work show a positive correlation between levels of 25(OH)D and anemia (i.e., hemoglobin, hematocrit, iron, iron saturation index, and ferritin). Conclusion: These results show the close relationship between the degree of anemia in patients with CKD and 25(OH)D levels. It is of great importance to maintain levels of 25(OH)D in patients with advanced-stage CKD, as this can decrease anemia levels and, in turn, lower quantities of erythropoietin would be necessary to maintain hematocrit.

Published in	American Journal of Clinical and Experimental Medicine (Volume 5, Issue 4)
DOI	10.11648/j.ajcem.20170504.18
Page(s)	151-156
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hemodialysis Patients, 25(OH) Vitamin D, Anemia

References

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APA Style

Elena López-Ramiro, Mercedes Rubert, Emilio González-Parra, Ignacio Mahillo, Concepción de la Piedra. (2017). Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease. American Journal of Clinical and Experimental Medicine, 5(4), 151-156. https://doi.org/10.11648/j.ajcem.20170504.18

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ACS Style

Elena López-Ramiro; Mercedes Rubert; Emilio González-Parra; Ignacio Mahillo; Concepción de la Piedra. Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease. Am. J. Clin. Exp. Med. 2017, 5(4), 151-156. doi: 10.11648/j.ajcem.20170504.18

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AMA Style

Elena López-Ramiro, Mercedes Rubert, Emilio González-Parra, Ignacio Mahillo, Concepción de la Piedra. Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease. Am J Clin Exp Med. 2017;5(4):151-156. doi: 10.11648/j.ajcem.20170504.18

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@article{10.11648/j.ajcem.20170504.18,
  author = {Elena López-Ramiro and Mercedes Rubert and Emilio González-Parra and Ignacio Mahillo and Concepción de la Piedra},
  title = {Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {4},
  pages = {151-156},
  doi = {10.11648/j.ajcem.20170504.18},
  url = {https://doi.org/10.11648/j.ajcem.20170504.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170504.18},
  abstract = {Introduction: Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis. Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD). Patients and methods: One hundred and forty-five patients with stage-5 CKD were studied (mean age 65.9 ± 14.6 years; 74 males and 71 females; Levels of 25(OH)D, age, bone alkaline phosphatase, procollagen I amino-terminal propeptide, carboxyterminal telopeptide of collagen I, intact parathyroid hormone (PTH), bio-PTH, hemoglobin, hematocrit, urea, creatinine, total proteins, albumin, iron, iron saturation index, calcium, phosphorous, total alkaline phosphatase, serum CO2, cholesterol, triglycerides, C-reactive protein, prealbumin, ferritin, proBNP, and fibroblast growth factor-23 (FGF-23) were determined. Spearman’s correlation coefficient and p values were analyzed. Results: This work show a positive correlation between levels of 25(OH)D and anemia (i.e., hemoglobin, hematocrit, iron, iron saturation index, and ferritin). Conclusion: These results show the close relationship between the degree of anemia in patients with CKD and 25(OH)D levels. It is of great importance to maintain levels of 25(OH)D in patients with advanced-stage CKD, as this can decrease anemia levels and, in turn, lower quantities of erythropoietin would be necessary to maintain hematocrit.},
 year = {2017}
}

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TY  - JOUR
T1  - Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease
AU  - Elena López-Ramiro
AU  - Mercedes Rubert
AU  - Emilio González-Parra
AU  - Ignacio Mahillo
AU  - Concepción de la Piedra
Y1  - 2017/07/18
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170504.18
DO  - 10.11648/j.ajcem.20170504.18
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 151
EP  - 156
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170504.18
AB  - Introduction: Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis. Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD). Patients and methods: One hundred and forty-five patients with stage-5 CKD were studied (mean age 65.9 ± 14.6 years; 74 males and 71 females; Levels of 25(OH)D, age, bone alkaline phosphatase, procollagen I amino-terminal propeptide, carboxyterminal telopeptide of collagen I, intact parathyroid hormone (PTH), bio-PTH, hemoglobin, hematocrit, urea, creatinine, total proteins, albumin, iron, iron saturation index, calcium, phosphorous, total alkaline phosphatase, serum CO2, cholesterol, triglycerides, C-reactive protein, prealbumin, ferritin, proBNP, and fibroblast growth factor-23 (FGF-23) were determined. Spearman’s correlation coefficient and p values were analyzed. Results: This work show a positive correlation between levels of 25(OH)D and anemia (i.e., hemoglobin, hematocrit, iron, iron saturation index, and ferritin). Conclusion: These results show the close relationship between the degree of anemia in patients with CKD and 25(OH)D levels. It is of great importance to maintain levels of 25(OH)D in patients with advanced-stage CKD, as this can decrease anemia levels and, in turn, lower quantities of erythropoietin would be necessary to maintain hematocrit.
VL  - 5
IS  - 4
ER  -

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Author Information

Elena López-Ramiro

Biochemistry Laboratory, Sanitary Research Institute Jiménez Díaz Foundation, Madrid, Spain
Mercedes Rubert

Biochemistry Laboratory, Sanitary Research Institute Jiménez Díaz Foundation, Madrid, Spain
Emilio González-Parra

Nefrology, Sanitary Research Institute Jiménez Díaz Foundation, Madrid, Spain
Ignacio Mahillo

Epidemiology and Statistics, Sanitary Research Institute Jiménez Díaz Foundation, Madrid, Spain
Concepción de la Piedra

Biochemistry Laboratory, Sanitary Research Institute Jiménez Díaz Foundation, Madrid, Spain

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Elena López-Ramiro, Mercedes Rubert, Emilio González-Parra, Ignacio Mahillo, Concepción de la Piedra. (2017). Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease. American Journal of Clinical and Experimental Medicine, 5(4), 151-156. https://doi.org/10.11648/j.ajcem.20170504.18

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ACS Style

Elena López-Ramiro; Mercedes Rubert; Emilio González-Parra; Ignacio Mahillo; Concepción de la Piedra. Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease. Am. J. Clin. Exp. Med. 2017, 5(4), 151-156. doi: 10.11648/j.ajcem.20170504.18

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AMA Style

Elena López-Ramiro, Mercedes Rubert, Emilio González-Parra, Ignacio Mahillo, Concepción de la Piedra. Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease. Am J Clin Exp Med. 2017;5(4):151-156. doi: 10.11648/j.ajcem.20170504.18

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@article{10.11648/j.ajcem.20170504.18,
  author = {Elena López-Ramiro and Mercedes Rubert and Emilio González-Parra and Ignacio Mahillo and Concepción de la Piedra},
  title = {Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {4},
  pages = {151-156},
  doi = {10.11648/j.ajcem.20170504.18},
  url = {https://doi.org/10.11648/j.ajcem.20170504.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170504.18},
  abstract = {Introduction: Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis. Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD). Patients and methods: One hundred and forty-five patients with stage-5 CKD were studied (mean age 65.9 ± 14.6 years; 74 males and 71 females; Levels of 25(OH)D, age, bone alkaline phosphatase, procollagen I amino-terminal propeptide, carboxyterminal telopeptide of collagen I, intact parathyroid hormone (PTH), bio-PTH, hemoglobin, hematocrit, urea, creatinine, total proteins, albumin, iron, iron saturation index, calcium, phosphorous, total alkaline phosphatase, serum CO2, cholesterol, triglycerides, C-reactive protein, prealbumin, ferritin, proBNP, and fibroblast growth factor-23 (FGF-23) were determined. Spearman’s correlation coefficient and p values were analyzed. Results: This work show a positive correlation between levels of 25(OH)D and anemia (i.e., hemoglobin, hematocrit, iron, iron saturation index, and ferritin). Conclusion: These results show the close relationship between the degree of anemia in patients with CKD and 25(OH)D levels. It is of great importance to maintain levels of 25(OH)D in patients with advanced-stage CKD, as this can decrease anemia levels and, in turn, lower quantities of erythropoietin would be necessary to maintain hematocrit.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease
AU  - Elena López-Ramiro
AU  - Mercedes Rubert
AU  - Emilio González-Parra
AU  - Ignacio Mahillo
AU  - Concepción de la Piedra
Y1  - 2017/07/18
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170504.18
DO  - 10.11648/j.ajcem.20170504.18
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 151
EP  - 156
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170504.18
AB  - Introduction: Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis. Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD). Patients and methods: One hundred and forty-five patients with stage-5 CKD were studied (mean age 65.9 ± 14.6 years; 74 males and 71 females; Levels of 25(OH)D, age, bone alkaline phosphatase, procollagen I amino-terminal propeptide, carboxyterminal telopeptide of collagen I, intact parathyroid hormone (PTH), bio-PTH, hemoglobin, hematocrit, urea, creatinine, total proteins, albumin, iron, iron saturation index, calcium, phosphorous, total alkaline phosphatase, serum CO2, cholesterol, triglycerides, C-reactive protein, prealbumin, ferritin, proBNP, and fibroblast growth factor-23 (FGF-23) were determined. Spearman’s correlation coefficient and p values were analyzed. Results: This work show a positive correlation between levels of 25(OH)D and anemia (i.e., hemoglobin, hematocrit, iron, iron saturation index, and ferritin). Conclusion: These results show the close relationship between the degree of anemia in patients with CKD and 25(OH)D levels. It is of great importance to maintain levels of 25(OH)D in patients with advanced-stage CKD, as this can decrease anemia levels and, in turn, lower quantities of erythropoietin would be necessary to maintain hematocrit.
VL  - 5
IS  - 4
ER  -

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