The Balance of Matrix Metalloproteinase-2 (Mmp-2) and Tissue Inhibitor of Matrix Metalloproteinase-2 (Timp-2) on Severe Endometriosis
Journal of Gynecology and Obstetrics
Volume 3, Issue 6, November 2015, Pages: 111-114
Received: Nov. 2, 2015; Accepted: Nov. 17, 2015; Published: Dec. 10, 2015
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Authors
Samrichard Rambulangi, Department of Obstetrics and Gynecology, Hasanuddin University, Makassar, Indonesia
Nusratuddin Abdullah, Department of Obstetrics and Gynecology, Hasanuddin University, Makassar, Indonesia
Irawan Yusuf, Department of Physiology, Hasanuddin University, Makassar, Indonesia
Syahrul Rauf, Department of Obstetrics and Gynecology, Hasanuddin University, Makassar, Indonesia
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Abstract
The objective of this study is to examine the level balance of serum and peritoneal fluid MMP-2 and TIMP-2 in patients with severe endometriosis. The method of this study was a cross sectional study with twenty patients were diagnosed as severe endometriosis based on laparoscopy and laparotomy with five controls. Serum samples were taken before surgery, peritoneal fluid samples were taken during surgery, and MMP-2 and TIMP-2 examination was conducted in the end of the study by using ELISA method. The mean level of serum, peritoneal fluid MMP-2 and TIMP-2 were compared by using unpaired t-test. Based on this study, we found that MMP-2 level of serum and peritoneal fluid was significantly different in the case compared to the control, 5.848±3.016 vs. 1.600±0.063 ng/mL and 1.977±1.883 vs. 0.573±0.084 ng/mL respectively. When TIMP-2 level of serum and peritoneal fluid compared to the control, the significant difference was only found in serum (p < 0.05), 0.853±0.343 vs. 0.637±0.116 ng/mL and 1.339±2.141 vs. 0.105±0.028 ng/mL respectively. This study showed that there was an increase of MMP-2 level of serum and peritoneal fluid and low level of serum and peritoneal TIMP-2 in severe endometriosis. Serum and peritoneal fluid MMP-2 as well as TIMP-2 in serum had a significant relationship with the incidence of severe endometriosis. Meanwhile, TIMP-2 in peritoneal fluid had no significant relationship with the incidence of severe endometriosis.
Keywords
MMP-2, TIMP-2, Severe Endometriosis
To cite this article
Samrichard Rambulangi, Nusratuddin Abdullah, Irawan Yusuf, Syahrul Rauf, The Balance of Matrix Metalloproteinase-2 (Mmp-2) and Tissue Inhibitor of Matrix Metalloproteinase-2 (Timp-2) on Severe Endometriosis, Journal of Gynecology and Obstetrics. Vol. 3, No. 6, 2015, pp. 111-114. doi: 10.11648/j.jgo.20150306.12
Copyright
Copyright © 2015 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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