Journal of Gynecology and Obstetrics

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Ovarian Hyperstimulation Syndrome Due to Exogenous Human Chorionic Gonadotropin (hCG) Presenting More Than 7 Days After hCG Administration

Received: 06 December 2017    Accepted: 23 December 2017    Published: 15 January 2018
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Abstract

We present a case of ovarian hyperstimulation syndrome (OHSS) occurring 8 days after human chorionic gonadotropin (hCG) administration. OHSS is classified as late type if it occurs 12 to 17 days after hCG administration and early type if it occurs within 7 days. Thus, the condition in this patient did not fit the definition of early or late OHSS. The OHSS was mild, and she recovered in approximately 10 days without requiring admission. The patient was not pregnant, and the OHSS was shown to be induced by exogenous hCG administration not endogenous hCG. In conclusion, OHSS can occur 8 to 11 days after hCG administration and it is important to distinguish whether OHSS is induced by endogenous or exogenous hCG.

DOI 10.11648/j.jgo.20170506.12
Published in Journal of Gynecology and Obstetrics (Volume 5, Issue 6, November 2017)
Page(s) 78-80
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ovarian Hyperstimulation Syndrome, Chorionic Gonadotropin, Ovarian Cysts, Clomiphene, Infertility

References
[1] Pereira N, Lekovich JP, Kligman I, et al. Severe ovarian hyperstimulation syndrome after combined GnRH-agonist and low-dose human chorionic gonadotropin trigger in a patient with a single kidney. Gynecol Endocrinol 2017; 33: 593-597.
[2] Keiser UB. The Pathogenesis of the Ovarian Hyperstimulation Syndrome. N Engl J Med 2003; 349: 729-732.
[3] Dahl Lyons CA, Wheeler CA, Frishman GN, et al. Early and late presentation of the ovarian hyperstimulation syndrome: two distinct entities with different risk factors. Hum Reprod 1994; 9: 792-799.
[4] Al-Shawaf T, Grudzinskas JG. Prevention and treatment of ovarian hyperstimulation syndrome. Best Prac Res Clinical Obstet Gynaecol 2003; 17: 249-261.
[5] Lee KH, Kim SH, Jee BC, et al. Comparison of clinical characteristics between early and late patterns in hospitalized patients with ovarian hyperstimulation syndrome. Fertil Steril 2010; 93: 2274-2280.
[6] Mathur RS, Akande AV, Keay SD, et al. Distinction between early and late ovarian hyperstimulation syndrome. Fertil Steril 2000; 73: 901-907.
[7] Korhonen K, Savolainen-Peltonen H, Mikkola T, et al. C-reactive protein response is higher in early than in late ovarian hyperstimulation syndrome. Eur J Obstet Gynecol Reprod Biol 2016; 207: 162-168.
[8] Papanikolaou EG, Tournaye H, Verpoest W, et al. Early and late ovarian hyperstimulation syndrome: early pregnancy outcome and profile. Hum Reprod 2005; 20: 636-641.
[9] Elena P, Isabel AM, Raul G, et al. Plasma levels of soluble vascular endothelial growth factor receptor-1 may determine the onset of early and late ovarian hyperstimulation syndrome. Hum Reprod 2006; 21: 1453–1460.
[10] Alper MM, Smith LP, Sills ES. Ovarian hyperstimulation syndrome: current views on pathophysiology, risk factors, prevention, and management. J Exp Clin Assist Reprod 2009; 6: 3.
[11] Jellad S, Haj HA, Basly M, et al. Vascular endothelial growth factor antagonist reduces the early onset and the severity of ovarian hyperstimulation syndrome. J Gynecol Obstet Hum Reprod 2017; 46: 87-91.
Author Information
  • Department of Obstetrics and Gynecology, Osaka University, Suita City, Osaka, Japan

  • Department of Obstetrics and Gynecology, Osaka University, Suita City, Osaka, Japan

  • Department of Obstetrics and Gynecology, Osaka University, Suita City, Osaka, Japan

  • Department of Obstetrics and Gynecology, Osaka University, Suita City, Osaka, Japan

  • Department of Obstetrics and Gynecology, Osaka University, Suita City, Osaka, Japan

  • Department of Obstetrics and Gynecology, Osaka University, Suita City, Osaka, Japan

  • Department of Obstetrics and Gynecology, Osaka University, Suita City, Osaka, Japan

Cite This Article
  • APA Style

    Masaki Kobayashi, Keiichi Kumasawa, Kaori Koizumi, Tsuyoshi Takiuchi, Hitomi Nakamura, et al. (2018). Ovarian Hyperstimulation Syndrome Due to Exogenous Human Chorionic Gonadotropin (hCG) Presenting More Than 7 Days After hCG Administration. Journal of Gynecology and Obstetrics, 5(6), 78-80. https://doi.org/10.11648/j.jgo.20170506.12

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    ACS Style

    Masaki Kobayashi; Keiichi Kumasawa; Kaori Koizumi; Tsuyoshi Takiuchi; Hitomi Nakamura, et al. Ovarian Hyperstimulation Syndrome Due to Exogenous Human Chorionic Gonadotropin (hCG) Presenting More Than 7 Days After hCG Administration. J. Gynecol. Obstet. 2018, 5(6), 78-80. doi: 10.11648/j.jgo.20170506.12

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    AMA Style

    Masaki Kobayashi, Keiichi Kumasawa, Kaori Koizumi, Tsuyoshi Takiuchi, Hitomi Nakamura, et al. Ovarian Hyperstimulation Syndrome Due to Exogenous Human Chorionic Gonadotropin (hCG) Presenting More Than 7 Days After hCG Administration. J Gynecol Obstet. 2018;5(6):78-80. doi: 10.11648/j.jgo.20170506.12

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  • @article{10.11648/j.jgo.20170506.12,
      author = {Masaki Kobayashi and Keiichi Kumasawa and Kaori Koizumi and Tsuyoshi Takiuchi and Hitomi Nakamura and Kenjiro Sawada and Tadashi Kimura},
      title = {Ovarian Hyperstimulation Syndrome Due to Exogenous Human Chorionic Gonadotropin (hCG) Presenting More Than 7 Days After hCG Administration},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {5},
      number = {6},
      pages = {78-80},
      doi = {10.11648/j.jgo.20170506.12},
      url = {https://doi.org/10.11648/j.jgo.20170506.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jgo.20170506.12},
      abstract = {We present a case of ovarian hyperstimulation syndrome (OHSS) occurring 8 days after human chorionic gonadotropin (hCG) administration. OHSS is classified as late type if it occurs 12 to 17 days after hCG administration and early type if it occurs within 7 days. Thus, the condition in this patient did not fit the definition of early or late OHSS. The OHSS was mild, and she recovered in approximately 10 days without requiring admission. The patient was not pregnant, and the OHSS was shown to be induced by exogenous hCG administration not endogenous hCG. In conclusion, OHSS can occur 8 to 11 days after hCG administration and it is important to distinguish whether OHSS is induced by endogenous or exogenous hCG.},
     year = {2018}
    }
    

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    AU  - Masaki Kobayashi
    AU  - Keiichi Kumasawa
    AU  - Kaori Koizumi
    AU  - Tsuyoshi Takiuchi
    AU  - Hitomi Nakamura
    AU  - Kenjiro Sawada
    AU  - Tadashi Kimura
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    JO  - Journal of Gynecology and Obstetrics
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    PB  - Science Publishing Group
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    AB  - We present a case of ovarian hyperstimulation syndrome (OHSS) occurring 8 days after human chorionic gonadotropin (hCG) administration. OHSS is classified as late type if it occurs 12 to 17 days after hCG administration and early type if it occurs within 7 days. Thus, the condition in this patient did not fit the definition of early or late OHSS. The OHSS was mild, and she recovered in approximately 10 days without requiring admission. The patient was not pregnant, and the OHSS was shown to be induced by exogenous hCG administration not endogenous hCG. In conclusion, OHSS can occur 8 to 11 days after hCG administration and it is important to distinguish whether OHSS is induced by endogenous or exogenous hCG.
    VL  - 5
    IS  - 6
    ER  - 

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