Pemphigoid gestationis, previously known as herpes gestationis, is a rare autoimmune bullous disease that manifests in pregnancy. Upon presentation, patients complain of intense pruritis, urticarial plaques, vesicles and bullae that primarily affect the peri-umbilical area before spreading to involve the rest of the body. The accurate diagnosis of pemphigoid gestationis is made histopathologically on biopsies, based on the presence of sub-epidermal vesicles, as well as direct visualization of linear deposition of C3 at the basement membrane zone by using immunofluorescence staining on those biopsies. The mainstay treatment of the disease remains corticosteroids. Prompt recognition and provision of the appropriate management allow a reduction in both maternal morbidity as well as fetal adverse perinatal outcomes. Pathologic skin dermatoses and diseases of pregnancy are rare and have different presentations, treatment and prognoses. This literature review includes an up to date comparison on the presentation, diagnosis and treatment of dermatoses in pregnancy, in order to help with the discrimination. A case of pemphigoid gestationis in a 15 year old woman is described. This is the youngest reported age of presentation of pemphigoid gestationis, raising the question of whether maternal age is a factor that can affect the course and the severity of the disease.
| Published in | Journal of Gynecology and Obstetrics (Volume 7, Issue 2) |
| DOI | 10.11648/j.jgo.20190702.14 |
| Page(s) | 46-50 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Pemphigoid Gestationis (PG), Herpes Gestationis, Pregnancy, Pruritis, Autoimmune, Major Histocompatibility Complex (MHC)
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APA Style
Emile Dabaj, Jana Abdo, Stephanie Yacoub, Rawad Halimeh, Zarouhie Bedoyan, et al. (2019). Pemphigoid Gestationis in a 15 Year Old Pregnant Patient, A Case Report and Literature Review. Journal of Gynecology and Obstetrics, 7(2), 46-50. https://doi.org/10.11648/j.jgo.20190702.14
ACS Style
Emile Dabaj; Jana Abdo; Stephanie Yacoub; Rawad Halimeh; Zarouhie Bedoyan, et al. Pemphigoid Gestationis in a 15 Year Old Pregnant Patient, A Case Report and Literature Review. J. Gynecol. Obstet. 2019, 7(2), 46-50. doi: 10.11648/j.jgo.20190702.14
AMA Style
Emile Dabaj, Jana Abdo, Stephanie Yacoub, Rawad Halimeh, Zarouhie Bedoyan, et al. Pemphigoid Gestationis in a 15 Year Old Pregnant Patient, A Case Report and Literature Review. J Gynecol Obstet. 2019;7(2):46-50. doi: 10.11648/j.jgo.20190702.14
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author = {Emile Dabaj and Jana Abdo and Stephanie Yacoub and Rawad Halimeh and Zarouhie Bedoyan and Joe Khalifeh},
title = {Pemphigoid Gestationis in a 15 Year Old Pregnant Patient, A Case Report and Literature Review},
journal = {Journal of Gynecology and Obstetrics},
volume = {7},
number = {2},
pages = {46-50},
doi = {10.11648/j.jgo.20190702.14},
url = {https://doi.org/10.11648/j.jgo.20190702.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190702.14},
abstract = {Pemphigoid gestationis, previously known as herpes gestationis, is a rare autoimmune bullous disease that manifests in pregnancy. Upon presentation, patients complain of intense pruritis, urticarial plaques, vesicles and bullae that primarily affect the peri-umbilical area before spreading to involve the rest of the body. The accurate diagnosis of pemphigoid gestationis is made histopathologically on biopsies, based on the presence of sub-epidermal vesicles, as well as direct visualization of linear deposition of C3 at the basement membrane zone by using immunofluorescence staining on those biopsies. The mainstay treatment of the disease remains corticosteroids. Prompt recognition and provision of the appropriate management allow a reduction in both maternal morbidity as well as fetal adverse perinatal outcomes. Pathologic skin dermatoses and diseases of pregnancy are rare and have different presentations, treatment and prognoses. This literature review includes an up to date comparison on the presentation, diagnosis and treatment of dermatoses in pregnancy, in order to help with the discrimination. A case of pemphigoid gestationis in a 15 year old woman is described. This is the youngest reported age of presentation of pemphigoid gestationis, raising the question of whether maternal age is a factor that can affect the course and the severity of the disease.},
year = {2019}
}
TY - JOUR T1 - Pemphigoid Gestationis in a 15 Year Old Pregnant Patient, A Case Report and Literature Review AU - Emile Dabaj AU - Jana Abdo AU - Stephanie Yacoub AU - Rawad Halimeh AU - Zarouhie Bedoyan AU - Joe Khalifeh Y1 - 2019/05/08 PY - 2019 N1 - https://doi.org/10.11648/j.jgo.20190702.14 DO - 10.11648/j.jgo.20190702.14 T2 - Journal of Gynecology and Obstetrics JF - Journal of Gynecology and Obstetrics JO - Journal of Gynecology and Obstetrics SP - 46 EP - 50 PB - Science Publishing Group SN - 2376-7820 UR - https://doi.org/10.11648/j.jgo.20190702.14 AB - Pemphigoid gestationis, previously known as herpes gestationis, is a rare autoimmune bullous disease that manifests in pregnancy. Upon presentation, patients complain of intense pruritis, urticarial plaques, vesicles and bullae that primarily affect the peri-umbilical area before spreading to involve the rest of the body. The accurate diagnosis of pemphigoid gestationis is made histopathologically on biopsies, based on the presence of sub-epidermal vesicles, as well as direct visualization of linear deposition of C3 at the basement membrane zone by using immunofluorescence staining on those biopsies. The mainstay treatment of the disease remains corticosteroids. Prompt recognition and provision of the appropriate management allow a reduction in both maternal morbidity as well as fetal adverse perinatal outcomes. Pathologic skin dermatoses and diseases of pregnancy are rare and have different presentations, treatment and prognoses. This literature review includes an up to date comparison on the presentation, diagnosis and treatment of dermatoses in pregnancy, in order to help with the discrimination. A case of pemphigoid gestationis in a 15 year old woman is described. This is the youngest reported age of presentation of pemphigoid gestationis, raising the question of whether maternal age is a factor that can affect the course and the severity of the disease. VL - 7 IS - 2 ER -
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