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Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells
Journal of Gynecology and Obstetrics
Volume 8, Issue 5, September 2020, Pages: 148-153
Received: Sep. 13, 2020; Accepted: Sep. 29, 2020; Published: Oct. 13, 2020
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Natalia Zakharenko, Endocrine Gynecology Department, NAMS Ukraine Institute of Pediatrics, Obstetrics and Gynecology, Kyiv, Ukraine
Oleksii Tatskiy, Department of Research and Development, International Biotherapy Institute, Kyiv, Ukraine
Sergii Konovalenko, Department of Research and Development, International Biotherapy Institute, Kyiv, Ukraine
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Background. Genital endometriosis (GE) remains a significantly common disease, occurring in 0.5-5% of fertile women and in 25-40% of women with infertility. In patients with GE, there is a decrease in apoptosis in endometrial cells compared to healthy women, even more pronounced in ectopic foci, as a result of which their proliferative activity increases and the ability to abnormal implantation increases. Objective. Our task was to study the patterns of interaction of immune cells with ectopic endometrial cells, as well as to determine the molecular biological levers of influence on immune surveillance in endometriosis. Given the ability of ectopic cells to change the microenvironment in their favor, we aimed to find an effective tool to restore immune surveillance of endometrioma and thus offer a promising treatment for the disease. Method. For the purpose of writing this review article, we used the method of selection and analysis of scientific publications with open access. Results. The use of immune peptides in endometriosis, which are capable of activating regulatory macrophages and stimulating the recruitment of T-lymphocytes, opens up new possibilities for controlling the disease. Arecur, which contains immune peptides, including defensins and RJP-1, tunes immune cells to maximize their productivity against ectopic tissue, potentially creating conditions for the prevention of endometriosis-associated ovarian cancer. Conclusion. The use of immune peptides in endometriosis quite predictably contributes to more efficient work of local immunity. Immune cells potentiated with peptides not only independently attack and separate the intercellular connections in the endometrioma, but also provoke apoptosis of ectopic cells. The use of immune peptides in endometriosis opens up new prospects for increasing the effectiveness of treatment and prevention of this disease.
Endometriosis, Ectopic Cells, Immune Surveillance, Immune Peptides, Arecur
To cite this article
Natalia Zakharenko, Oleksii Tatskiy, Sergii Konovalenko, Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells, Journal of Gynecology and Obstetrics. Vol. 8, No. 5, 2020, pp. 148-153. doi: 10.11648/j.jgo.20200805.14
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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