Journal of Gynecology and Obstetrics

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Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018

Received: 04 September 2020    Accepted: 21 September 2020    Published: 30 October 2020
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Abstract

Objective: Study the fetal-maternal and neonantal prognosis of sickle cell pregnancies managed in Cotonou’s hospitals (R. Benin). Material and methods: This is a descriptive study on retrospective data from January 2008 to December 2018. The maternities of the Lagoon Mother and Child Hospital and University (CHU-MEL) center and of the CNHU/HKM gynecology and obstetrics university clinic had served as a framework. Complete patients records were analyzed. Included were pregnant women or delivered at 28 weeks of amenorrhea (AW) or beyond, sickle cell disease SS or SC confirmed by hemoglobin electrophoresis. Sociodemographic, clinical, therapeutic, and fetal-maternal and neonatal prognosis were analyzed. EPI DATA 3.1 and SPSS 2.0 software were used to analyze our data. The difference is significant for a p-value ≤ 5%. Ethical and professional standards and rules were respected. Results: The delivery of a patient suffering from sickle cell disease represented 0.82% of births. The SS phenotype was observed in 27.3% (n=105) versus 72.7% (n=279) of SC (p=0.000). A history of obstetric complications was noted in 56.8% (n=218). The course of the current pregnancy was marked by obstetric complications in 97.4% and the most important were: the threat of premature delivery (28%) and the vaso-occlusive crisis (19.5%). The caesarean was performed in 92% of sickle cell patients. Premature delivery was observed in 60% with 6.3% very premature (28-33AW). It was registered 91% (n=352) live births, 48% (n=169) hypotrophs, 60% premature, 1.1% (n=4) intrapartum deaths and 8% (n=4) intrapartum deaths and 8% (n=31) deaths in utero. Perinatal mortality represented 9%. The after-effects of childbirth were complicated in 12% (n=46). The puerperal infections (32.6%), hypertension (28.2%) and its complications and severe anemia (19.2%) were the most common complications. Five (5) maternal deaths were deplored, ie a mortality rate of 1420 maternal deaths per 100,000 live births. Conclusion: In Benin, pregnancy and delivery of sickle cell disease are at high risk of fetal, maternal and neonatal mortality. Caesarean section was almost routine in this group. The practice of transfusion exchange or bleeding may improve prognosis.

DOI 10.11648/j.jgo.20200806.11
Published in Journal of Gynecology and Obstetrics (Volume 8, Issue 6, November 2020)
Page(s) 154-160
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pregnancy, Sickle Cell Disease, Mortality, Benin

References
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Author Information
  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

  • Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin

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    Dangbemey Djima Patrice, Tognifode Veronique, Azonbakin Simon, Tchiakpe-Enialoko Nicole, Aboubakar Moufalilou, et al. (2020). Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018. Journal of Gynecology and Obstetrics, 8(6), 154-160. https://doi.org/10.11648/j.jgo.20200806.11

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    Dangbemey Djima Patrice; Tognifode Veronique; Azonbakin Simon; Tchiakpe-Enialoko Nicole; Aboubakar Moufalilou, et al. Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018. J. Gynecol. Obstet. 2020, 8(6), 154-160. doi: 10.11648/j.jgo.20200806.11

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    AMA Style

    Dangbemey Djima Patrice, Tognifode Veronique, Azonbakin Simon, Tchiakpe-Enialoko Nicole, Aboubakar Moufalilou, et al. Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018. J Gynecol Obstet. 2020;8(6):154-160. doi: 10.11648/j.jgo.20200806.11

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  • @article{10.11648/j.jgo.20200806.11,
      author = {Dangbemey Djima Patrice and Tognifode Veronique and Azonbakin Simon and Tchiakpe-Enialoko Nicole and Aboubakar Moufalilou and Ogoudjobi Mathieu and Lokossou Symphorose and Nzikou Venance and Tshabu-Aguemon Christiane and Hounkpatin Benjamin and Tonato-Bagnan Josiane and Denakpo Lewis},
      title = {Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {8},
      number = {6},
      pages = {154-160},
      doi = {10.11648/j.jgo.20200806.11},
      url = {https://doi.org/10.11648/j.jgo.20200806.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jgo.20200806.11},
      abstract = {Objective: Study the fetal-maternal and neonantal prognosis of sickle cell pregnancies managed in Cotonou’s hospitals (R. Benin). Material and methods: This is a descriptive study on retrospective data from January 2008 to December 2018. The maternities of the Lagoon Mother and Child Hospital and University (CHU-MEL) center and of the CNHU/HKM gynecology and obstetrics university clinic had served as a framework. Complete patients records were analyzed. Included were pregnant women or delivered at 28 weeks of amenorrhea (AW) or beyond, sickle cell disease SS or SC confirmed by hemoglobin electrophoresis. Sociodemographic, clinical, therapeutic, and fetal-maternal and neonatal prognosis were analyzed. EPI DATA 3.1 and SPSS 2.0 software were used to analyze our data. The difference is significant for a p-value ≤ 5%. Ethical and professional standards and rules were respected. Results: The delivery of a patient suffering from sickle cell disease represented 0.82% of births. The SS phenotype was observed in 27.3% (n=105) versus 72.7% (n=279) of SC (p=0.000). A history of obstetric complications was noted in 56.8% (n=218). The course of the current pregnancy was marked by obstetric complications in 97.4% and the most important were: the threat of premature delivery (28%) and the vaso-occlusive crisis (19.5%). The caesarean was performed in 92% of sickle cell patients. Premature delivery was observed in 60% with 6.3% very premature (28-33AW). It was registered 91% (n=352) live births, 48% (n=169) hypotrophs, 60% premature, 1.1% (n=4) intrapartum deaths and 8% (n=4) intrapartum deaths and 8% (n=31) deaths in utero. Perinatal mortality represented 9%. The after-effects of childbirth were complicated in 12% (n=46). The puerperal infections (32.6%), hypertension (28.2%) and its complications and severe anemia (19.2%) were the most common complications. Five (5) maternal deaths were deplored, ie a mortality rate of 1420 maternal deaths per 100,000 live births. Conclusion: In Benin, pregnancy and delivery of sickle cell disease are at high risk of fetal, maternal and neonatal mortality. Caesarean section was almost routine in this group. The practice of transfusion exchange or bleeding may improve prognosis.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018
    AU  - Dangbemey Djima Patrice
    AU  - Tognifode Veronique
    AU  - Azonbakin Simon
    AU  - Tchiakpe-Enialoko Nicole
    AU  - Aboubakar Moufalilou
    AU  - Ogoudjobi Mathieu
    AU  - Lokossou Symphorose
    AU  - Nzikou Venance
    AU  - Tshabu-Aguemon Christiane
    AU  - Hounkpatin Benjamin
    AU  - Tonato-Bagnan Josiane
    AU  - Denakpo Lewis
    Y1  - 2020/10/30
    PY  - 2020
    N1  - https://doi.org/10.11648/j.jgo.20200806.11
    DO  - 10.11648/j.jgo.20200806.11
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 154
    EP  - 160
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20200806.11
    AB  - Objective: Study the fetal-maternal and neonantal prognosis of sickle cell pregnancies managed in Cotonou’s hospitals (R. Benin). Material and methods: This is a descriptive study on retrospective data from January 2008 to December 2018. The maternities of the Lagoon Mother and Child Hospital and University (CHU-MEL) center and of the CNHU/HKM gynecology and obstetrics university clinic had served as a framework. Complete patients records were analyzed. Included were pregnant women or delivered at 28 weeks of amenorrhea (AW) or beyond, sickle cell disease SS or SC confirmed by hemoglobin electrophoresis. Sociodemographic, clinical, therapeutic, and fetal-maternal and neonatal prognosis were analyzed. EPI DATA 3.1 and SPSS 2.0 software were used to analyze our data. The difference is significant for a p-value ≤ 5%. Ethical and professional standards and rules were respected. Results: The delivery of a patient suffering from sickle cell disease represented 0.82% of births. The SS phenotype was observed in 27.3% (n=105) versus 72.7% (n=279) of SC (p=0.000). A history of obstetric complications was noted in 56.8% (n=218). The course of the current pregnancy was marked by obstetric complications in 97.4% and the most important were: the threat of premature delivery (28%) and the vaso-occlusive crisis (19.5%). The caesarean was performed in 92% of sickle cell patients. Premature delivery was observed in 60% with 6.3% very premature (28-33AW). It was registered 91% (n=352) live births, 48% (n=169) hypotrophs, 60% premature, 1.1% (n=4) intrapartum deaths and 8% (n=4) intrapartum deaths and 8% (n=31) deaths in utero. Perinatal mortality represented 9%. The after-effects of childbirth were complicated in 12% (n=46). The puerperal infections (32.6%), hypertension (28.2%) and its complications and severe anemia (19.2%) were the most common complications. Five (5) maternal deaths were deplored, ie a mortality rate of 1420 maternal deaths per 100,000 live births. Conclusion: In Benin, pregnancy and delivery of sickle cell disease are at high risk of fetal, maternal and neonatal mortality. Caesarean section was almost routine in this group. The practice of transfusion exchange or bleeding may improve prognosis.
    VL  - 8
    IS  - 6
    ER  - 

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