Journal of Gynecology and Obstetrics

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Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Received: 12 November 2015    Accepted: 24 November 2015    Published: 30 December 2015
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Abstract

Background: Group B Streptococcus (GBS) is an important cause of maternal and neonatal morbidity and mortality in many parts of the world. It has been implicated in adverse pregnancy outcomes. Maternal colonization has been found to be a major risk factor for invasive neonatal GBS disease. The main objective of this study was to identify the risk factors of Group B streptococcus colonization and its effect on pregnancy outcome. Methods: This was a prospective study in which pregnant women attending antenatal clinic (ANC) at Dr George Mukhari Hospital (DGMH) were recruited. These were at least18 years old and were at 16 weeks gestation. Vaginal and rectal swabs were taken at recruitment. Follow up of mothers until six weeks post-delivery and babies until three months of age was done. Results: A total of 340 pregnant women were then investigated for GBS colonization. Out of this number, 164 (48.2%) were GBS positive. The majority of the women (62.1%) were parity 1 and 2. Group B Streptococcus colonization was significant in women who had no matric education and who were unemployed. There was a significantly higher GBS colonization in women with previous history of miscarriages and stillbirths. The proportion of HIV positive, GBS colonized women was significant at 41.5% as compared to HIV negative GBS colonized (34.7%). Eight women (4.9%) presented with premature rupture of membranes (PROM) and the duration ranged from 0.5 to 72 hours. Ten (6.1%) women had preterm deliveries. Three (1.8%) women had wound sepsis post caesarean section and one (0.6%) had endometritis post vaginal delivery. A total of 7 (24.1%) babies were GBS positive. The number of live babies delivered was 167, with 1 case of miscarriage due to severe preeclampsia. There were 2 cases of early neonatal deaths which included 1 case of sepsis whereas the other one had multiple congenital abnormalities. Conclusion: Colonization by GBS in pregnant women at DGMH was high. Maternal risk factors identified were previous history of stillbirths/miscarriages, lack of education and being HIV positive. Overall pregnancy outcome both maternal and foetal was good.

DOI 10.11648/j.jgo.20150306.14
Published in Journal of Gynecology and Obstetrics (Volume 3, Issue 6, November 2015)
Page(s) 121-128
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Group B Streptococcus, Risk Factors, Pregnancy, HIV, South Africa

References
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Author Information
  • Department of Obstetrics and Gynaecology, Sefako Makgatho Health Sciences University, Pretoria, South Africa

  • Department of Medical Microbiology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe; Department of Health Sciences, Faculty of Health and Applied Sciences, Namibia University of Science and Technology, Windhoek, Namibia

  • Department of Health Sciences, Faculty of Health and Applied Sciences, Namibia University of Science and Technology, Windhoek, Namibia

  • Department of Life and Consumer Sciences, College of Agriculture & Environmental Science, University of South Africa, Pretoria, South Africa

  • Department of Life and Consumer Sciences, College of Agriculture & Environmental Science, University of South Africa, Pretoria, South Africa

  • Department of Life and Consumer Sciences, College of Agriculture & Environmental Science, University of South Africa, Pretoria, South Africa

  • Department of Life and Consumer Sciences, College of Agriculture & Environmental Science, University of South Africa, Pretoria, South Africa

  • Department of Microbiological Pathology, Sefako Makgatho Health Sciences University, Pretoria, South Africa

  • Department of Obstetrics and Gynaecology, Sefako Makgatho Health Sciences University, Pretoria, South Africa

  • Department of Obstetrics and Gynaecology, Sefako Makgatho Health Sciences University, Pretoria, South Africa

Cite This Article
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    Lucia Matsiane Lekala, Rooyen Tinago Mavenyengwa, Sylvester Rogers Moyo, Sogolo Lucky Lebelo, John Yenga Bolukaoto, et al. (2015). Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome. Journal of Gynecology and Obstetrics, 3(6), 121-128. https://doi.org/10.11648/j.jgo.20150306.14

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    ACS Style

    Lucia Matsiane Lekala; Rooyen Tinago Mavenyengwa; Sylvester Rogers Moyo; Sogolo Lucky Lebelo; John Yenga Bolukaoto, et al. Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome. J. Gynecol. Obstet. 2015, 3(6), 121-128. doi: 10.11648/j.jgo.20150306.14

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    AMA Style

    Lucia Matsiane Lekala, Rooyen Tinago Mavenyengwa, Sylvester Rogers Moyo, Sogolo Lucky Lebelo, John Yenga Bolukaoto, et al. Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome. J Gynecol Obstet. 2015;3(6):121-128. doi: 10.11648/j.jgo.20150306.14

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  • @article{10.11648/j.jgo.20150306.14,
      author = {Lucia Matsiane Lekala and Rooyen Tinago Mavenyengwa and Sylvester Rogers Moyo and Sogolo Lucky Lebelo and John Yenga Bolukaoto and Martina Onyedi Chukwu and Charles Maropeng Monyama and Maphoshane Nchabeleng and Tshimane Charles Tshepuwane and Sam Monokoane},
      title = {Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {3},
      number = {6},
      pages = {121-128},
      doi = {10.11648/j.jgo.20150306.14},
      url = {https://doi.org/10.11648/j.jgo.20150306.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jgo.20150306.14},
      abstract = {Background: Group B Streptococcus (GBS) is an important cause of maternal and neonatal morbidity and mortality in many parts of the world. It has been implicated in adverse pregnancy outcomes. Maternal colonization has been found to be a major risk factor for invasive neonatal GBS disease. The main objective of this study was to identify the risk factors of Group B streptococcus colonization and its effect on pregnancy outcome. Methods: This was a prospective study in which pregnant women attending antenatal clinic (ANC) at Dr George Mukhari Hospital (DGMH) were recruited. These were at least18 years old and were at 16 weeks gestation. Vaginal and rectal swabs were taken at recruitment. Follow up of mothers until six weeks post-delivery and babies until three months of age was done. Results: A total of 340 pregnant women were then investigated for GBS colonization. Out of this number, 164 (48.2%) were GBS positive. The majority of the women (62.1%) were parity 1 and 2. Group B Streptococcus colonization was significant in women who had no matric education and who were unemployed. There was a significantly higher GBS colonization in women with previous history of miscarriages and stillbirths. The proportion of HIV positive, GBS colonized women was significant at 41.5% as compared to HIV negative GBS colonized (34.7%). Eight women (4.9%) presented with premature rupture of membranes (PROM) and the duration ranged from 0.5 to 72 hours. Ten (6.1%) women had preterm deliveries. Three (1.8%) women had wound sepsis post caesarean section and one (0.6%) had endometritis post vaginal delivery. A total of 7 (24.1%) babies were GBS positive. The number of live babies delivered was 167, with 1 case of miscarriage due to severe preeclampsia. There were 2 cases of early neonatal deaths which included 1 case of sepsis whereas the other one had multiple congenital abnormalities. Conclusion: Colonization by GBS in pregnant women at DGMH was high. Maternal risk factors identified were previous history of stillbirths/miscarriages, lack of education and being HIV positive. Overall pregnancy outcome both maternal and foetal was good.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome
    AU  - Lucia Matsiane Lekala
    AU  - Rooyen Tinago Mavenyengwa
    AU  - Sylvester Rogers Moyo
    AU  - Sogolo Lucky Lebelo
    AU  - John Yenga Bolukaoto
    AU  - Martina Onyedi Chukwu
    AU  - Charles Maropeng Monyama
    AU  - Maphoshane Nchabeleng
    AU  - Tshimane Charles Tshepuwane
    AU  - Sam Monokoane
    Y1  - 2015/12/30
    PY  - 2015
    N1  - https://doi.org/10.11648/j.jgo.20150306.14
    DO  - 10.11648/j.jgo.20150306.14
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 121
    EP  - 128
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20150306.14
    AB  - Background: Group B Streptococcus (GBS) is an important cause of maternal and neonatal morbidity and mortality in many parts of the world. It has been implicated in adverse pregnancy outcomes. Maternal colonization has been found to be a major risk factor for invasive neonatal GBS disease. The main objective of this study was to identify the risk factors of Group B streptococcus colonization and its effect on pregnancy outcome. Methods: This was a prospective study in which pregnant women attending antenatal clinic (ANC) at Dr George Mukhari Hospital (DGMH) were recruited. These were at least18 years old and were at 16 weeks gestation. Vaginal and rectal swabs were taken at recruitment. Follow up of mothers until six weeks post-delivery and babies until three months of age was done. Results: A total of 340 pregnant women were then investigated for GBS colonization. Out of this number, 164 (48.2%) were GBS positive. The majority of the women (62.1%) were parity 1 and 2. Group B Streptococcus colonization was significant in women who had no matric education and who were unemployed. There was a significantly higher GBS colonization in women with previous history of miscarriages and stillbirths. The proportion of HIV positive, GBS colonized women was significant at 41.5% as compared to HIV negative GBS colonized (34.7%). Eight women (4.9%) presented with premature rupture of membranes (PROM) and the duration ranged from 0.5 to 72 hours. Ten (6.1%) women had preterm deliveries. Three (1.8%) women had wound sepsis post caesarean section and one (0.6%) had endometritis post vaginal delivery. A total of 7 (24.1%) babies were GBS positive. The number of live babies delivered was 167, with 1 case of miscarriage due to severe preeclampsia. There were 2 cases of early neonatal deaths which included 1 case of sepsis whereas the other one had multiple congenital abnormalities. Conclusion: Colonization by GBS in pregnant women at DGMH was high. Maternal risk factors identified were previous history of stillbirths/miscarriages, lack of education and being HIV positive. Overall pregnancy outcome both maternal and foetal was good.
    VL  - 3
    IS  - 6
    ER  - 

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