Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study

Soriba Naby Camara; Oumar Taibata Balde; Ahmed Boubacar Barry; Ibrahima Sory Souare; Sadamoudou Traore; Naby Laye Moussa Keita; Aboubacar Sylla; Foulematou Soumah; Diowen Goviden; Aboubacar Toure; Fode Abass Cisse; Amara Cisse; Salifou Camara; Mamadou Traore; Mohamed Kerfalla Camara; Fode Mohamed Sylla; Sneha Ballah

doi:doi:10.11648/j.ja.20150306.11

Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study

Soriba Naby Camara, Oumar Taibata Balde, Ahmed Boubacar Barry, Ibrahima Sory Souare, Sadamoudou Traore, Naby Laye Moussa Keita, Aboubacar Sylla, Foulematou Soumah, Diowen Goviden, Aboubacar Toure, Fode Abass Cisse, Amara Cisse, Salifou Camara, Mamadou Traore, Mohamed Kerfalla Camara, Fode Mohamed Sylla, Sneha Ballah

Published in Journal of Anesthesiology (Volume 3, Issue 6)

Received: 12 February 2016 Accepted: 14 May 2016 Published: 8 June 2016

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Abstract

Post-operative analgesia is crucial to facilitate early ambulation, prevent complications, increase patient satisfaction while ensuring a faster recovery pace. Opioid analgesics have been recognized as the mainstay for treatment of acute pain in a majority of postoperative care units. Intravenous patient-controlled analgesia (IVPCA) with the opioids drugs sufentanil and fentanyl has proven to be effective when used in the immediate postoperative period. The aim of the study was to determine the efficacy and safety of sufentanil for postoperative analgesia based on the same principle, and, fentanyl citrate was chosen as a control drug for upper and lower abdominal operations under general anesthesia. Methodology; It was a prospective clinical study carried out at Union hospital, from December 2014 to March 2015. 240 patients were scheduled for upper and lower abdominal surgery requiring general anesthesia. They were divided into four groups: test group (A) and control group (B); (C) and (D), and are given fentanyl and sufentanil by IVPCA for postoperative analgesia relief following surgery. Pain was assessed by the visual analogue Scale. The determined pain relief; pulse rate, BP, ECG, sedation score, SPO2, pruritus score, nausea score and vomiting score were all recorded for each patient. Results The pressing times values show that fentanyl (A) and high dose sufentanil (C, D) both provided a satisfactory level of analgesia. Moreover, VAS scores of the patients on high dose sufentanil (C, D) were lower, implying superior analgesic effects at these doses. However, low dose sufentanil (B) may only provide limited and inadequate analgesia. The degree of pruritus was less marked in patients on sufentanil than those on fentanyl as demonstrated by the lower Pruritus scores in sufentanil groups (B, C, D). Low dose sufentanil and fentanyl have shown to have similar extent of side effects overall. Conclusion It was found that sufentanil had superior analgesic effect to that of fentanyl in patients who had undergone open abdominal surgery. The extent of the occurrence of adverse reactions to light in the low-dose sufentanil group (B) is less than that in the high-dose groups (C, D), the concentration of persistent postoperative analgesia sufentanil should reach 0.02μg / (kg ml), and the flow rate maintained at 2ml / h.

Published in	Journal of Anesthesiology (Volume 3, Issue 6)
DOI	10.11648/j.ja.20150306.11
Page(s)	25-29
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Sufentanil, Pain, Analgesia Postoperative, IVPCA, General Anesthesia, Upper Surgery, Low Surgery, Wuhan Union Hospital

References

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[2]	Van Bever, W. F., C. J. Niemegeers, K. H. Schellekens, and P. A. Janssen. "N-4-Substituted 1-(2-arylethyl)-4-piperidinyl-N-phenylpropanamides, a novel series of extremely potent analgesics with unusually high safety margin."Arzneimittel-Forschung 26, no. 8 (1975): 1548-1551
[3]	Savoia, G., M. Loreto, and E. Gravino. "Sufentanil: an overview of its use for acute pain management." Minerva anestesiologica 67, no. 9 Suppl 1 (2001): 206-216.
[4]	Modh, Dixit B., Kavita Lalchandani, and Neha Jain. "Comparison of post operative analgesia with Fentanyl and Sulfentanil via epidural route in thoracic and upper abdominal surgeries." (2014).
[5]	Kiricojević, Vesna D., Milovan D. Ivanović, I. V. Mićović, J. B. Đorđević, Goran M. Roglić, and Ljiljana I. Došen-Mićović. "An optimized synthesis of a key pharmaceutical intermediate methyl 4-[(1-oxopropyl) phenylamino] piperidine-4-carboxylate." Journal of the Serbian Chemical Society 67, no. 12 (2002): 793-802.
[6]	Fredheim, O. M., P. C. Borchgrevink, and G. Kvarstein." [Post-operative pain management in hospitals]." Tidsskrift for den Norske laegeforening: tidsskrift for praktiskmedicin, nyraekke 131, no. 18 (2011): 1772-1776.
[7]	Thipphawong, John B., Najib Babul, Richard J. Morishige, Hugh K. Findlay, Keith R. Reber, Gary J. Millward, and Babatunde A. Otulana. "Analgesic efficacy of inhaled morphine in patients after bunionectomysurgery."Anesthesiology 99, no. 3 (2003): 693-700.
[8]	Palmer, Pamela P. "Single-and Repeat-Dose Pharmacokinetics g p of Sublingual Sufentanil NanoTab^™ in Healthy Volunteers." (2009).
[9]	Niemegeers, C. J., K. H. Schellekens, W. F. Van Bever, and P. A. Janssen."Sufentanil, a very potent and extremely safe intravenous morphine-like compound in mice, rats and dogs." Arzneimittel-Forschung 26, no. 8 (1975): 1551-1556.
[10]	Bailey, Peter L., Talmage D. Egan, and Theodore H. Stanley. "Intravenous opioid anesthetics." Anesthesia 5 (2000): 273-376.
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[12]	-Grass. J. A. Sufentanil; clinical use as post operative analgesic-epidural/intrathecalroute. J. Pain symptoms manage 1992. jul, 7 (5) 271-286.
[13]	Yun Sic Bang, Kum-Hee Chung, Jung Hyang Lee, Seung-Ki Hong, Seok Hwan Choi, Yong-Yeon Lee, Su-Yon Lee and Hyeon Jeong Yang; Comparison of clinical effect according to the dosage of sufentanil added to 0.5% hyperbaric bupivacaine for spinal anesthesia in patients undergoing cesarean section. Korean J. Anesthesiol 2012 oct 63 (4) 321-326.
[14]	Jorgen B. Dahl, Inge S. Jeppesen, Henrick Jorgensen, Jorn Wettersiew, Steen Moiniche. Intra opreative and postoperative analgesic Efficacy and Adverse Effects of Intrathecal opioids in patients undergoing cesarean section with spinal anesthesia; Anesthesiology 12 1992, vol 91, 1919.
[15]	Angelica de Fatima de Assuncao Braga, Franlin Sarmento da Silva Braga, Eunice Sizue Hirata, Rosa. Costa Pereira, Jose Aristeu Frias, Isadora Fregonese Antunes; Association of lipophilic opioids and hyperbaric bupivacaine in spinal anesthesia for elective cesarean section. Randomized controlled study. Acta Cir. Bras. Vol 29 No 11. Sao Paulo Nov 2014.
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Soriba Naby Camara, Oumar Taibata Balde, Ahmed Boubacar Barry, Ibrahima Sory Souare, Sadamoudou Traore, et al. (2016). Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study. International Journal of Anesthesia and Clinical Medicine, 3(6), 25-29. https://doi.org/10.11648/j.ja.20150306.11

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Soriba Naby Camara; Oumar Taibata Balde; Ahmed Boubacar Barry; Ibrahima Sory Souare; Sadamoudou Traore, et al. Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study. Int. J. Anesth. Clin. Med. 2016, 3(6), 25-29. doi: 10.11648/j.ja.20150306.11

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Soriba Naby Camara, Oumar Taibata Balde, Ahmed Boubacar Barry, Ibrahima Sory Souare, Sadamoudou Traore, et al. Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study. Int J Anesth Clin Med. 2016;3(6):25-29. doi: 10.11648/j.ja.20150306.11

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@article{10.11648/j.ja.20150306.11,
  author = {Soriba Naby Camara and Oumar Taibata Balde and Ahmed Boubacar Barry and Ibrahima Sory Souare and Sadamoudou Traore and Naby Laye Moussa Keita and Aboubacar Sylla and Foulematou Soumah and Diowen Goviden and Aboubacar Toure and Fode Abass Cisse and Amara Cisse and Salifou Camara and Mamadou Traore and Mohamed Kerfalla Camara and Fode Mohamed Sylla and Sneha Ballah},
  title = {Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {3},
  number = {6},
  pages = {25-29},
  doi = {10.11648/j.ja.20150306.11},
  url = {https://doi.org/10.11648/j.ja.20150306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20150306.11},
  abstract = {Post-operative analgesia is crucial to facilitate early ambulation, prevent complications, increase patient satisfaction while ensuring a faster recovery pace. Opioid analgesics have been recognized as the mainstay for treatment of acute pain in a majority of postoperative care units. Intravenous patient-controlled analgesia (IVPCA) with the opioids drugs sufentanil and fentanyl has proven to be effective when used in the immediate postoperative period. The aim of the study was to determine the efficacy and safety of sufentanil for postoperative analgesia based on the same principle, and, fentanyl citrate was chosen as a control drug for upper and lower abdominal operations under general anesthesia. Methodology; It was a prospective clinical study carried out at Union hospital, from December 2014 to March 2015. 240 patients were scheduled for upper and lower abdominal surgery requiring general anesthesia. They were divided into four groups: test group (A) and control group (B); (C) and (D), and are given fentanyl and sufentanil by IVPCA for postoperative analgesia relief following surgery. Pain was assessed by the visual analogue Scale. The determined pain relief; pulse rate, BP, ECG, sedation score, SPO2, pruritus score, nausea score and vomiting score were all recorded for each patient. Results The pressing times values show that fentanyl (A) and high dose sufentanil (C, D) both provided a satisfactory level of analgesia. Moreover, VAS scores of the patients on high dose sufentanil (C, D) were lower, implying superior analgesic effects at these doses. However, low dose sufentanil (B) may only provide limited and inadequate analgesia. The degree of pruritus was less marked in patients on sufentanil than those on fentanyl as demonstrated by the lower Pruritus scores in sufentanil groups (B, C, D). Low dose sufentanil and fentanyl have shown to have similar extent of side effects overall. Conclusion It was found that sufentanil had superior analgesic effect to that of fentanyl in patients who had undergone open abdominal surgery. The extent of the occurrence of adverse reactions to light in the low-dose sufentanil group (B) is less than that in the high-dose groups (C, D), the concentration of persistent postoperative analgesia sufentanil should reach 0.02μg / (kg ml), and the flow rate maintained at 2ml / h.},
 year = {2016}
}

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TY  - JOUR
T1  - Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study
AU  - Soriba Naby Camara
AU  - Oumar Taibata Balde
AU  - Ahmed Boubacar Barry
AU  - Ibrahima Sory Souare
AU  - Sadamoudou Traore
AU  - Naby Laye Moussa Keita
AU  - Aboubacar Sylla
AU  - Foulematou Soumah
AU  - Diowen Goviden
AU  - Aboubacar Toure
AU  - Fode Abass Cisse
AU  - Amara Cisse
AU  - Salifou Camara
AU  - Mamadou Traore
AU  - Mohamed Kerfalla Camara
AU  - Fode Mohamed Sylla
AU  - Sneha Ballah
Y1  - 2016/06/08
PY  - 2016
N1  - https://doi.org/10.11648/j.ja.20150306.11
DO  - 10.11648/j.ja.20150306.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 25
EP  - 29
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20150306.11
AB  - Post-operative analgesia is crucial to facilitate early ambulation, prevent complications, increase patient satisfaction while ensuring a faster recovery pace. Opioid analgesics have been recognized as the mainstay for treatment of acute pain in a majority of postoperative care units. Intravenous patient-controlled analgesia (IVPCA) with the opioids drugs sufentanil and fentanyl has proven to be effective when used in the immediate postoperative period. The aim of the study was to determine the efficacy and safety of sufentanil for postoperative analgesia based on the same principle, and, fentanyl citrate was chosen as a control drug for upper and lower abdominal operations under general anesthesia. Methodology; It was a prospective clinical study carried out at Union hospital, from December 2014 to March 2015. 240 patients were scheduled for upper and lower abdominal surgery requiring general anesthesia. They were divided into four groups: test group (A) and control group (B); (C) and (D), and are given fentanyl and sufentanil by IVPCA for postoperative analgesia relief following surgery. Pain was assessed by the visual analogue Scale. The determined pain relief; pulse rate, BP, ECG, sedation score, SPO2, pruritus score, nausea score and vomiting score were all recorded for each patient. Results The pressing times values show that fentanyl (A) and high dose sufentanil (C, D) both provided a satisfactory level of analgesia. Moreover, VAS scores of the patients on high dose sufentanil (C, D) were lower, implying superior analgesic effects at these doses. However, low dose sufentanil (B) may only provide limited and inadequate analgesia. The degree of pruritus was less marked in patients on sufentanil than those on fentanyl as demonstrated by the lower Pruritus scores in sufentanil groups (B, C, D). Low dose sufentanil and fentanyl have shown to have similar extent of side effects overall. Conclusion It was found that sufentanil had superior analgesic effect to that of fentanyl in patients who had undergone open abdominal surgery. The extent of the occurrence of adverse reactions to light in the low-dose sufentanil group (B) is less than that in the high-dose groups (C, D), the concentration of persistent postoperative analgesia sufentanil should reach 0.02μg / (kg ml), and the flow rate maintained at 2ml / h.
VL  - 3
IS  - 6
ER  -

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Author Information

Soriba Naby Camara

Department of Pancreatic Surgery, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Oumar Taibata Balde

Department of Visceral Surgery, National Hospital of Donka, University Gamal Abdel Nasser of Conakry, Conakry, Guinea
Ahmed Boubacar Barry

Department of Visceral Surgery, National Hospital of Donka, University Gamal Abdel Nasser of Conakry, Conakry, Guinea
Ibrahima Sory Souare

Department of Neurosurgery, Friendship Hospital Sino Guinea, University Gamal Abdel Nasser of Conakry, Conakry Guinea
Sadamoudou Traore

Department of Medical Imaging, Good Shepherd Medical Center, Longview, Texas
Naby Laye Moussa Keita

Department of Biochemistry, University Gamal Abdel Nasser of Conakry, Conakry Guinea
Aboubacar Sylla

Department of Biochemistry, University Gamal Abdel Nasser of Conakry, Conakry Guinea
Foulematou Soumah

Department of Anesthesia, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China
Diowen Goviden

Department of Anesthesia, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China
Aboubacar Toure

Depatment of General Surgery, National Hospital of Ignace Deen, University Gamal Abdel Nasser of Conakry, Conakry, Guinea
Fode Abass Cisse

Department of Neurology, National Hospital of Ignace Deen, University Gamal Abdel Nasser of Conakry, Conakry, Guinea
Amara Cisse

Department of Neurology, National Hospital of Ignace Deen, University Gamal Abdel Nasser of Conakry, Conakry, Guinea
Salifou Camara

Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry Guinea
Mamadou Traore

Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry Guinea
Mohamed Kerfalla Camara

Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry Guinea
Fode Mohamed Sylla

Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry Guinea
Sneha Ballah

Department of Internal Medicine Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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APA Style

Soriba Naby Camara, Oumar Taibata Balde, Ahmed Boubacar Barry, Ibrahima Sory Souare, Sadamoudou Traore, et al. (2016). Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study. International Journal of Anesthesia and Clinical Medicine, 3(6), 25-29. https://doi.org/10.11648/j.ja.20150306.11

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ACS Style

Soriba Naby Camara; Oumar Taibata Balde; Ahmed Boubacar Barry; Ibrahima Sory Souare; Sadamoudou Traore, et al. Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study. Int. J. Anesth. Clin. Med. 2016, 3(6), 25-29. doi: 10.11648/j.ja.20150306.11

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AMA Style

Soriba Naby Camara, Oumar Taibata Balde, Ahmed Boubacar Barry, Ibrahima Sory Souare, Sadamoudou Traore, et al. Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study. Int J Anesth Clin Med. 2016;3(6):25-29. doi: 10.11648/j.ja.20150306.11

Copy | Download

@article{10.11648/j.ja.20150306.11,
  author = {Soriba Naby Camara and Oumar Taibata Balde and Ahmed Boubacar Barry and Ibrahima Sory Souare and Sadamoudou Traore and Naby Laye Moussa Keita and Aboubacar Sylla and Foulematou Soumah and Diowen Goviden and Aboubacar Toure and Fode Abass Cisse and Amara Cisse and Salifou Camara and Mamadou Traore and Mohamed Kerfalla Camara and Fode Mohamed Sylla and Sneha Ballah},
  title = {Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {3},
  number = {6},
  pages = {25-29},
  doi = {10.11648/j.ja.20150306.11},
  url = {https://doi.org/10.11648/j.ja.20150306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20150306.11},
  abstract = {Post-operative analgesia is crucial to facilitate early ambulation, prevent complications, increase patient satisfaction while ensuring a faster recovery pace. Opioid analgesics have been recognized as the mainstay for treatment of acute pain in a majority of postoperative care units. Intravenous patient-controlled analgesia (IVPCA) with the opioids drugs sufentanil and fentanyl has proven to be effective when used in the immediate postoperative period. The aim of the study was to determine the efficacy and safety of sufentanil for postoperative analgesia based on the same principle, and, fentanyl citrate was chosen as a control drug for upper and lower abdominal operations under general anesthesia. Methodology; It was a prospective clinical study carried out at Union hospital, from December 2014 to March 2015. 240 patients were scheduled for upper and lower abdominal surgery requiring general anesthesia. They were divided into four groups: test group (A) and control group (B); (C) and (D), and are given fentanyl and sufentanil by IVPCA for postoperative analgesia relief following surgery. Pain was assessed by the visual analogue Scale. The determined pain relief; pulse rate, BP, ECG, sedation score, SPO2, pruritus score, nausea score and vomiting score were all recorded for each patient. Results The pressing times values show that fentanyl (A) and high dose sufentanil (C, D) both provided a satisfactory level of analgesia. Moreover, VAS scores of the patients on high dose sufentanil (C, D) were lower, implying superior analgesic effects at these doses. However, low dose sufentanil (B) may only provide limited and inadequate analgesia. The degree of pruritus was less marked in patients on sufentanil than those on fentanyl as demonstrated by the lower Pruritus scores in sufentanil groups (B, C, D). Low dose sufentanil and fentanyl have shown to have similar extent of side effects overall. Conclusion It was found that sufentanil had superior analgesic effect to that of fentanyl in patients who had undergone open abdominal surgery. The extent of the occurrence of adverse reactions to light in the low-dose sufentanil group (B) is less than that in the high-dose groups (C, D), the concentration of persistent postoperative analgesia sufentanil should reach 0.02μg / (kg ml), and the flow rate maintained at 2ml / h.},
 year = {2016}
}

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TY  - JOUR
T1  - Observation on Clinical Effects of Postoperative Analgesia with Sufentanil After Upper and Lower Abdominal Surgery: A Prospective Study
AU  - Soriba Naby Camara
AU  - Oumar Taibata Balde
AU  - Ahmed Boubacar Barry
AU  - Ibrahima Sory Souare
AU  - Sadamoudou Traore
AU  - Naby Laye Moussa Keita
AU  - Aboubacar Sylla
AU  - Foulematou Soumah
AU  - Diowen Goviden
AU  - Aboubacar Toure
AU  - Fode Abass Cisse
AU  - Amara Cisse
AU  - Salifou Camara
AU  - Mamadou Traore
AU  - Mohamed Kerfalla Camara
AU  - Fode Mohamed Sylla
AU  - Sneha Ballah
Y1  - 2016/06/08
PY  - 2016
N1  - https://doi.org/10.11648/j.ja.20150306.11
DO  - 10.11648/j.ja.20150306.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 25
EP  - 29
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20150306.11
AB  - Post-operative analgesia is crucial to facilitate early ambulation, prevent complications, increase patient satisfaction while ensuring a faster recovery pace. Opioid analgesics have been recognized as the mainstay for treatment of acute pain in a majority of postoperative care units. Intravenous patient-controlled analgesia (IVPCA) with the opioids drugs sufentanil and fentanyl has proven to be effective when used in the immediate postoperative period. The aim of the study was to determine the efficacy and safety of sufentanil for postoperative analgesia based on the same principle, and, fentanyl citrate was chosen as a control drug for upper and lower abdominal operations under general anesthesia. Methodology; It was a prospective clinical study carried out at Union hospital, from December 2014 to March 2015. 240 patients were scheduled for upper and lower abdominal surgery requiring general anesthesia. They were divided into four groups: test group (A) and control group (B); (C) and (D), and are given fentanyl and sufentanil by IVPCA for postoperative analgesia relief following surgery. Pain was assessed by the visual analogue Scale. The determined pain relief; pulse rate, BP, ECG, sedation score, SPO2, pruritus score, nausea score and vomiting score were all recorded for each patient. Results The pressing times values show that fentanyl (A) and high dose sufentanil (C, D) both provided a satisfactory level of analgesia. Moreover, VAS scores of the patients on high dose sufentanil (C, D) were lower, implying superior analgesic effects at these doses. However, low dose sufentanil (B) may only provide limited and inadequate analgesia. The degree of pruritus was less marked in patients on sufentanil than those on fentanyl as demonstrated by the lower Pruritus scores in sufentanil groups (B, C, D). Low dose sufentanil and fentanyl have shown to have similar extent of side effects overall. Conclusion It was found that sufentanil had superior analgesic effect to that of fentanyl in patients who had undergone open abdominal surgery. The extent of the occurrence of adverse reactions to light in the low-dose sufentanil group (B) is less than that in the high-dose groups (C, D), the concentration of persistent postoperative analgesia sufentanil should reach 0.02μg / (kg ml), and the flow rate maintained at 2ml / h.
VL  - 3
IS  - 6
ER  -

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