Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.
| Published in |
International Journal of Biomedical Science and Engineering (Volume 2, Issue 6-1)
This article belongs to the Special Issue Cancer Research |
| DOI | 10.11648/j.ijbse.s.2014020601.11 |
| Page(s) | 1-6 |
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Stem Cells, Myelodysplastic Syndrome, Microenvironment, Signaling Pathways, Therapy
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APA Style
Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet. (2014). Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. International Journal of Biomedical Science and Engineering, 2(6-1), 1-6. https://doi.org/10.11648/j.ijbse.s.2014020601.11
ACS Style
Armel Herve Nwabo Kamdje; Paul Faustin Seke Etet. Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. Int. J. Biomed. Sci. Eng. 2014, 2(6-1), 1-6. doi: 10.11648/j.ijbse.s.2014020601.11
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Download@article{10.11648/j.ijbse.s.2014020601.11,
author = {Armel Herve Nwabo Kamdje and Paul Faustin Seke Etet},
title = {Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes},
journal = {International Journal of Biomedical Science and Engineering},
volume = {2},
number = {6-1},
pages = {1-6},
doi = {10.11648/j.ijbse.s.2014020601.11},
url = {https://doi.org/10.11648/j.ijbse.s.2014020601.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.s.2014020601.11},
abstract = {Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.},
year = {2014}
}
TY - JOUR T1 - Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes AU - Armel Herve Nwabo Kamdje AU - Paul Faustin Seke Etet Y1 - 2014/11/05 PY - 2014 N1 - https://doi.org/10.11648/j.ijbse.s.2014020601.11 DO - 10.11648/j.ijbse.s.2014020601.11 T2 - International Journal of Biomedical Science and Engineering JF - International Journal of Biomedical Science and Engineering JO - International Journal of Biomedical Science and Engineering SP - 1 EP - 6 PB - Science Publishing Group SN - 2376-7235 UR - https://doi.org/10.11648/j.ijbse.s.2014020601.11 AB - Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique. VL - 2 IS - 6-1 ER -
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