International Journal of Biomedical Science and Engineering

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Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining

Received: 19 July 2014    Accepted: 19 December 2014    Published: 27 January 2015
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Abstract

The treatment of breast cancer, the most common malignancy among women worldwide, remains puzzling partly due to the resistance to therapeutics, which associates with the heterogeneity of case clinical presentations, and limits in the current understanding of the pathogenesis of solid cancers. Notably, it remains unclear: (i) whether breast cancer starts strictly as a local disease before metastasizing to the lymph nodes and distant organs, i.e. if cancer initiating cells are local cells that have undergone epithelial to mesenchymal transition; (ii) or if breast cancer is intrinsically a systemic disease started by malfunctioning circulating mesenchymal stem cells (MSCs) infiltrating the breast stroma to start tumorigenesis. Such limits in our understanding of breast cancer biology have been slowing the development of MSC-based therapies exploiting the ability of these cells to home into tumorigenic sites, kill cancer cells, stop neoangiogenesis, and repair damaged tissues, as well as therapeutic approaches using these cells as vehicle for gene therapy and for delivering anticancer therapeutics, which are potential game changing therapeutic approaches, particularly in currently incurable cancers and intractable cases. Major drawbacks to MSC-based therapy implementation and use in breast cancer are herein briefly discussed.

DOI 10.11648/j.ijbse.s.2014020601.13
Published in International Journal of Biomedical Science and Engineering (Volume 2, Issue 6-1, December 2014)

This article belongs to the Special Issue Cancer Research

Page(s) 20-24
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Stem Cells, Breast Cancer, Microenvironment, Signaling Pathways, Therapy, Therapeutic Resistance

References
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Author Information
  • Department of Biomedical Sciences, University of Ngaoundere, PO Box 454, Ngaoundere-Cameroon

  • Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Al-Qaseem, Saudi Arabia

  • Department of Biochemistry College of Medicine Room 4D30.5 Health Sciences Bldg University of Saskatchewan, 107 Wiggins Road Saskatoon, SK. S7N 5E5 Canada

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    Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet, Kiven Erique Lukong. (2015). Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining. International Journal of Biomedical Science and Engineering, 2(6-1), 20-24. https://doi.org/10.11648/j.ijbse.s.2014020601.13

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    ACS Style

    Armel Herve Nwabo Kamdje; Paul Faustin Seke Etet; Kiven Erique Lukong. Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining. Int. J. Biomed. Sci. Eng. 2015, 2(6-1), 20-24. doi: 10.11648/j.ijbse.s.2014020601.13

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    AMA Style

    Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet, Kiven Erique Lukong. Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining. Int J Biomed Sci Eng. 2015;2(6-1):20-24. doi: 10.11648/j.ijbse.s.2014020601.13

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  • @article{10.11648/j.ijbse.s.2014020601.13,
      author = {Armel Herve Nwabo Kamdje and Paul Faustin Seke Etet and Kiven Erique Lukong},
      title = {Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining},
      journal = {International Journal of Biomedical Science and Engineering},
      volume = {2},
      number = {6-1},
      pages = {20-24},
      doi = {10.11648/j.ijbse.s.2014020601.13},
      url = {https://doi.org/10.11648/j.ijbse.s.2014020601.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijbse.s.2014020601.13},
      abstract = {The treatment of breast cancer, the most common malignancy among women worldwide, remains puzzling partly due to the resistance to therapeutics, which associates with the heterogeneity of case clinical presentations, and limits in the current understanding of the pathogenesis of solid cancers. Notably, it remains unclear: (i) whether breast cancer starts strictly as a local disease before metastasizing to the lymph nodes and distant organs, i.e. if cancer initiating cells are local cells that have undergone epithelial to mesenchymal transition; (ii) or if breast cancer is intrinsically a systemic disease started by malfunctioning circulating mesenchymal stem cells (MSCs) infiltrating the breast stroma to start tumorigenesis. Such limits in our understanding of breast cancer biology have been slowing the development of MSC-based therapies exploiting the ability of these cells to home into tumorigenic sites, kill cancer cells, stop neoangiogenesis, and repair damaged tissues, as well as therapeutic approaches using these cells as vehicle for gene therapy and for delivering anticancer therapeutics, which are potential game changing therapeutic approaches, particularly in currently incurable cancers and intractable cases. Major drawbacks to MSC-based therapy implementation and use in breast cancer are herein briefly discussed.},
     year = {2015}
    }
    

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    T1  - Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining
    AU  - Armel Herve Nwabo Kamdje
    AU  - Paul Faustin Seke Etet
    AU  - Kiven Erique Lukong
    Y1  - 2015/01/27
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    DO  - 10.11648/j.ijbse.s.2014020601.13
    T2  - International Journal of Biomedical Science and Engineering
    JF  - International Journal of Biomedical Science and Engineering
    JO  - International Journal of Biomedical Science and Engineering
    SP  - 20
    EP  - 24
    PB  - Science Publishing Group
    SN  - 2376-7235
    UR  - https://doi.org/10.11648/j.ijbse.s.2014020601.13
    AB  - The treatment of breast cancer, the most common malignancy among women worldwide, remains puzzling partly due to the resistance to therapeutics, which associates with the heterogeneity of case clinical presentations, and limits in the current understanding of the pathogenesis of solid cancers. Notably, it remains unclear: (i) whether breast cancer starts strictly as a local disease before metastasizing to the lymph nodes and distant organs, i.e. if cancer initiating cells are local cells that have undergone epithelial to mesenchymal transition; (ii) or if breast cancer is intrinsically a systemic disease started by malfunctioning circulating mesenchymal stem cells (MSCs) infiltrating the breast stroma to start tumorigenesis. Such limits in our understanding of breast cancer biology have been slowing the development of MSC-based therapies exploiting the ability of these cells to home into tumorigenic sites, kill cancer cells, stop neoangiogenesis, and repair damaged tissues, as well as therapeutic approaches using these cells as vehicle for gene therapy and for delivering anticancer therapeutics, which are potential game changing therapeutic approaches, particularly in currently incurable cancers and intractable cases. Major drawbacks to MSC-based therapy implementation and use in breast cancer are herein briefly discussed.
    VL  - 2
    IS  - 6-1
    ER  - 

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