International Journal of Clinical Dermatology
Volume 2, Issue 1, June 2019, Pages: 1-6
Received: Sep. 29, 2018;
Accepted: Feb. 15, 2019;
Published: Jun. 11, 2019
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Eke Chidinma Nwanneamaka, Department of Human Physiology, Nnamdi Azikiwe University, Awka, Nigeria
Nwogueze Bartholomew Chukwuebuka, Department of Human Physiology, Delta State University, Abraka, Nigeria
Ossai Nduka Richard, Department of Human Physiology, Delta State University, Abraka, Nigeria
Nwobodo Ed, Department of Human Physiology, Nnamdi Azikiwe University, Awka, Nigeria
Reduced lung volumes have been a complication associated with chronic diabetes mellitus but these findings have been made in other parts of the world with few kinds of literature in relation to this subject matter, in Nigeria. A focus on diabetic Nigerian females for the first time will add in filling the information gap on how pulmonary functions are affected in diabetics from this part of the world in comparison to their counterparts from other parts of the world.166 female subjects (83 subjects as control subjects and 83 subjects as study subjects), aged between 30-68 years participated in this study. Lung function test was carried out on the subjects and on analyzing the data obtained, it was seen that there is a decline in pulmonary function in diabetics. This study concludes that diabetic subjects show a decrease in pulmonary function parameters (Peak Expiratory Flow Rate- PEFR, Forced Vital Capacity- FVC, Forced Expiratory Volume in one second- FEV₁ and FVC/FEV₁% ratio). Also, interplay of anthropometric data and not their individual actions result in negative effect on pulmonary function. Proper pulmonary function test and other investigations may reduce the risk of mortality among diabetics
Eke Chidinma Nwanneamaka,
Nwogueze Bartholomew Chukwuebuka,
Ossai Nduka Richard,
Pulmonary Function in Females with Type 2 Diabetes in AWKA, Anambra State, International Journal of Clinical Dermatology.
Vol. 2, No. 1,
2019, pp. 1-6.
Agarwal, V., Gupta, B., Dev, P., Kumar, Y., Ahmad, N. and Gupta, K. K. (2009). Deterioration of the lung functions in type II diabetic subjects from northern India. Indian J. Physiol. Pharmacol; 53 (2): 189–191.
Ahmed, S. and Joshi, A. A. (2015). A study of pulmonary function test in type 2 diabetics. International Journal of Current Research in Life Sciences. 4 (3): 177-179.
Anandhalakshmi, S., Manikandan, S., Ramachandran, C. (2013). Alveolar gas exchange and pulmonary functions in patients with type II diabetes mellitus. J. Clin. Diagn Res. 7 (9): 1874–1877.
Araoye, M. O. (2003). Data collection in: Research methodology with statistics for health and social sciences. Ilorin: Nathadex Publishers. Pp130-159.
Arnalich, F., Hernanz, A., López-Maderuelo, D., Peña, J. M., Camacho, J., Madero, R., Vázquez, J. J. and Montiel, C. (2000). Enhanced acute-phase response and oxidative stress in older adults with type II diabetes. Horm. Metab. Res. 32 (10): 407-12.
Barrett-Connor, E., Frette, C. (1996). NIDDM, impaired glucose tolerance, and pulmonary function in older adults. Diabetes Care; 19: 1441–1444.
Borst, B., Gosker, H., Zeegers, M. and Schols, A. (2010). Pulmonary Functions in Diabetes: A Metaanalysis. Chest. 138 (2): 393-406.
Cavan, D. A., Parkes, A., O'Donnell, M. J., Freeman, W., and Cayton, R. M. (1991). Lung function and diabetes. Respir Med. 85 (3): 257–258.
Chance, W. W., Rhee, C. and Yilmaz, C. (2008). Diminished alveolar microvascular reserves in type 2 diabetes reflect systemic microangiopathy. Diabetes Care. 31: 1596-1601.
Cirillo, D., Agrawal, Y. and Cassano, P. (2002). Lipids and pulmonary function in the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 155 (9): 842-8.
Davis, T. M., Knuiman, M., Kendall, P., Vu, H. and Davis, W. A. (2000). Reduced pulmonary function and its associations in type 2 diabetes: the Fremantle Diabetes Study. Diabetes Res Clin Pract. 50 (2): 153-9.
Davis, W. A., Knuiman, M., Grange, V., Davis, T. M. E. (2004). Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes. Diabetes Care. 27: 752–757.
Defronzo, R. A. (2009). Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 58: 773-795.
Dennis, R. J., Maldonado, D., Rojas, M. X., Aschner, P., Rondon, M., Charry, L. and Casas, A. (2010). Inadequate glucose control in type 2 diabetes is associated with impaired lung function and systemic inflammation: a cross-sectional study. BMC Pulm Med.10: 38.
Erukainure, O. L., Ebuehi, O. T., Adeboyejo, F. O., Aliyu, M. and Elemo, G. M. (2014). Modulatory Effect of Fibre-enriched Cake on Alloxan-induced Diabetic Toxicity in Rat Brain Tissues. Toxicology Reports. 1: 445-449.
Faith, K., Sebila, D., Ferhan, C. and Sefa, O. (2010). Inspiratory muscle strength is correlated with carnitine levels in type 2 diabetes. Endocr. Res. 35 (2): 51–58.
Gispen, W. H. and Biessels, G. J. (2000). Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci. 23: 542–549.
Kabay, S. C., Ozden, H., Guven, G., Ustuner, M. C., Degirmenci, I., Olgun, E. G. and Unal, N. (2009). Protective effects of vitamin E on central nervoussystem in streptozotocin-induced diabetic rats. Clin. Invest. Med. 32 (5): 314–321.
Kaminski, D. M., Schaan, B. D., da Silva, A. M., Soares, P. P., Plentz, R. D. and Dall’Ago, P. (2011). Inspiratory muscle weakness is associated with autonomic cardiovascular dysfunction in patients with type 2 diabetes mellitus. Clin Auton Res. 21 (1): 29-35.
Litonjua, A. A., Lazarus, R., Sparrow, D., Demollesm D. and Weiss, S. T. (2005). Lung function in type 2 diabetes: the Normative Aging Study. Respir Med. 99 (12): 1583–1590.
Mahmoud, M. E., Mohammed, A. A. and Hany, A. E. (2014). Impact of diabetes mellitus and its control on pulmonary functions and cardiopulmonary exercise tests. Egyptian Journal of Chest Diseases and Tuberculosis. 63: 471–476.
McKeever, T. M., Weston, P. J., Hubbard, R. and Fogarty, A. (2005). Lung Function and Glucose Metabolism: An Analysis of Data from the Third National Health and Nutrition Examination Survey. American Journal of Epidemiology. 161 (6): 546-556.
Murea M., Ma L. and Freedman B. 2012. Genetic and environmental factors associated with typr 2 diabetes and diabetic vascular complications. Rev Diabet Stud. 9 (1): 6-22.
Nandhini, R., Syed, S. S. S. and Saikumar, P. (2012). Respiratory myopathy in type II diabetes mellitus. J ClinDiagn Res. 6: 354-57.
Osho, O. A., Akinbo, S. R. A., Osinubi, A. A. A. and Olawale, A. O. (2012). Effect of Progressive Aerobic and Resistance Exercises on the Pulmonary Functions of Individuals with Type 2 Diabetes in Nigeria. Int J endocrinolmetab. 10 (1): 411-417.
Ozoh, O. B., Okubabejo, N. U., Bandele, E. O. and Chukwu, C. C. (2010). Ventilatory Function in Nigerians with Type 2 Diabetes. The African Journal of Respiratory Medicine. 5: 18-22.
Prajakta C. and Archana J. 2016. Effect of Weight Reduction on Peak Expiratory Flow Rate in Young Obese Individuals. IOSR Journal of Dental and Medical Sciences. 15 (3): 1-5.
Rother, K. I. (2007). Diabetes Treatment- Bridging the Divide. N Engl J Med. 356 (15): 1499-1501.
Ruppel, G. L (2012). What is the Clinical Value For Lung Volumes? Respiratory Care. 57 (1): 26-28.
Shoback., David, G., Gardner., Dolores. (2011). Greenspan ‘s basic & clinical endocrinology (9th ed.). New York: McGraw-Hill Medical. Pp17.
Shravya, K. G., Sharan, B., Singh, M., Hari, K. B., Suresh, M., Preetham, J. K. and Mallikarjuna, R. N. (2012). Deterioration of Pulmonary Functions in Type 2 Diabetes Mellitus. IOSR Journal of Pharmacy and Biological Sciences. 1 (1): 39-43.
Spero, D. (2016). What is a Normal Blood Sugar Level? Diabetes Self-Management. Retrieved from https://www.diabetesselfmanagement.com/blog/what-is-a-normal-blood-sugar-level 21/1/ 2017.
Stolar, M. W., Hoogwerf, B. J., Boyle, P. J., Gorshow, S. M and Wales, D. O. (2008). Managing Type 2 Diabetes: Going Beyond Glycemic Control. Journal of Managed Care and Specialty Pharmacy. 14 (5B): 1-22.
Walter, R. E, Beiser, A, Givelber, R. J. 2003. Association between glycemic state and lung function: the Framingham Heart Study. Am J RespirCrit Care Med. 167: 911–6.
Wanke, T., Formanek, D., Auinger, M., Popp, W., Zwick, H. and Irsigler, K. (1991). Inspiratory muscle performance and pulmonary function changes in insulin-dependent diabetes mellitus. Am. Rev. Respir. Dis. 143: 97–100.
Yamamoto M., Yamaguchi T., Yamauchi M., Kaji H. and Sugimoto T. 2009. Diabetic Patients Have an Increased Risk of Vertebral Fractures Independent of BMD or Diabetic Complications. Journal of Bone and Mineral Research. 24 (4): 702-709.
Yeh, H. C., Punjabi, N. M., Wang, N. Y., Pankow, J. S., Duncan, B. B. and Brancati, F. L. (2005). Vital capacity as a predictor of incident type 2 diabetes: the Atherosclerosis Risk in Communities study. Diabetes Care. 28 (6): 1472–1479.