Two Cases of Palmoplantar Pustulosis Treated with Oral Rinse Using Ozone Nano-bubble Water in Addition to Conventional Topical Therapy
International Journal of Clinical Dermatology
Volume 2, Issue 1, June 2019, Pages: 7-9
Received: Jul. 30, 2019;
Accepted: Aug. 28, 2019;
Published: Oct. 4, 2019
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Yasuhiro Horiuchi, Division of Dermatology, Tsuruse Orthopedic Clinic, Saitama, Japan
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Background: Palmoplantar pustulosis (PPP) is a unique, chronic inflammatory skin disease characterized by pustules and erythematous lesions on specific sites, such as the palms and soles; however, the etiology and treatment of the condition are not clearly established. Recently, oral bacteria have been proposed as the possible causative factor of PPP. Ozone nano-bubble (ONB) water, treated with nano-sized ozone gas particles, shows strong sterilizing activity and has been attracting attention as a new treatment method not only for periodontal disease but also for PPP. Case history: This report presents the cases of two female patients with PPP who underwent treatment using a mixture of topical vitamin D and steroid ointments for over 6 months. However, the skin lesions did not show much improvement. Owing to the antimicrobial activity of ozone, they voluntarily agreed to rinsing their oral cavities with ozone water, particularly the periodontal areas, for a couple of minutes with 10–20 ml of ONB water, each night, in conjunction with the previous topical treatment.Results: Their skin lesions resolved completely within several months of addition of ONB water oral rinse to the routine topical treatment. Conclusion: The results support the usefulness of ONB water as an effective therapeutic means for the resolution of skin lesions in patients with PPP.
Palmoplantar Pustulosis, Oral Bacteria, Ozone Nano-bubble Water
To cite this article
Two Cases of Palmoplantar Pustulosis Treated with Oral Rinse Using Ozone Nano-bubble Water in Addition to Conventional Topical Therapy, International Journal of Clinical Dermatology.
Vol. 2, No. 1,
2019, pp. 7-9.
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Brunasso G, Massone C. Palmoplantar pustulosis: Epidemiology, clinical features, and diagnosis. Up To Date 2015 [open access]
Olazagasti JM, Ma JE, Wetter DA. Clinical features, etiologic factors, associated disorders, and treatment of palmoplantar pustulosis: The Mayo Clinic experience, 1996-2013. Mayo Clinic Proc 2017; 92 (9): 1351-8.
Kikuchi N, YamamotoT. Dental infection as a triggering factor for palmoplantar pustulosis. Acta Derm Venereol 2013; 93 (6): 721-2.
Murai O, Suwabe K, Ohkawa Y, et al. Palmoplantar pustulosis and periodontal therapy. Nihon Shishubyo Gakkai Kaishi 2018; 60 (3): 131-8. [in Japanese].
Muro M, Kawakami H, Matsumoto Y, et al. Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. J Dermatolog Treat 2016; 27 (1): 51-3.
Agren-Jonsson S, Tegner E. PUVA therapy for palmoplantar pustulosis. Acta Derm Venereol 1985; 65 (6): 531-5.
Horiuchi Y. Palmoplantar pustulosis: Oral bacteria as a causative factor and ozone as an effective therapeutic means? Our Dermatol Online 2019; 10 (4):398-9.
Dufresne S, Hewitt A, Robitaille S. Ozone sterilization: Another option for healthcare in the 21st Century. Am J Inf Cont 2004; 32 (3): e26-7.
Hayakumo S, Arakawa S, Takahashi M, et al. Effects of ozone nano-bubble water on periodontopathic bacteria and oral cells- in vitro studies. Sci Tech Adv Mater 2014; 15: 055003.
Hayakumo S, Arakawa S, Mano Y, et al. Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial. Clin Oral Investig 2013; 17 (2): 379-88.