International Journal of Clinical Dermatology

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Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study

Received: 04 April 2020    Accepted: 22 April 2020    Published: 09 June 2020
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Abstract

Background: Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 2–3%. Psoriasis is caused by a complex interplay among the immune system, genetic background, auto-antigens, and environmental factors. Trace elements are required for the normal functioning of many enzymes and play a significant role in the development of many diseases. Objective: To assess the serum levels of zinc, copper, magnesium, iron and folate in patients with psoriasis compared to healthy controls. Patients and Methods: A total of 41 patients with psoriasis vulgaris were compared with 50 age and sex matched healthy subjects. Serum levels of zinc (Zn), copper (Cu), magnesium (Mg), iron (Fe) and folate were measured in both groups and compared. Psoriasis Area and Severity Index (PASI) were used to measure the severity of the disease. Results: The mean serum level of Zn was 142.2±52 in patients compared to 90.2±18.9 in the controls (P=.000), serum level of Cu was 161.1±58.5 in patients versus 156.3±42.8 in control group (P=.650). Serum Mg was 2.4±0.5 in patients and 1.9±0.2 in control subjects (P=.000). Serum Fe was 90.8±50 in patients as compared to 116.9±32.4 in control subjects (P=.004), whereas, serum folate was 6.6±3.9 in patients and 9.5±5.3 in control subjects (P=.005). There was no significant direct correlation between levels of trace elements under study and PASI scoring. Conclusions: Trace elements particularly Zn, Cu, and Mg appear to be elevated in psoriasis patients, while Fe and folate were low in psoriatic patients, however, they can't serve as biomarkers for disease activity.

DOI 10.11648/j.ijcd.20200301.14
Published in International Journal of Clinical Dermatology (Volume 3, Issue 1, June 2020)
Page(s) 15-18
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Psoriasis Vulgaris, Trace Elements, PASI

References
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[4] Wacewicz M, Socha K, Soroczyńska J, Niczyporuk M, Aleksiejczuk P, Ostrowska J, Borawska MH. Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: A case-control study. J Trace Elem Med Biol. 2017; 44: 109-114.
[5] Butnaru C., Pascu M., Mircea C. Serum zinc and copper levels in some dermatological diseases. Rev. Med. Chir. Soc. Med. Nat. Iasi. 2008; (1): 253-57.
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Author Information
  • Dermatology Department, Faculty of Medicine, Benghazi University, Benghazi, Libya

  • Dermatology Department, Omar El-Mukhtar University, Al-Beida, Libya

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    Nadia Abdalhafid El Sherif, Salwa Abdalsalam El-Dibany. (2020). Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study. International Journal of Clinical Dermatology, 3(1), 15-18. https://doi.org/10.11648/j.ijcd.20200301.14

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    ACS Style

    Nadia Abdalhafid El Sherif; Salwa Abdalsalam El-Dibany. Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study. Int. J. Clin. Dermatol. 2020, 3(1), 15-18. doi: 10.11648/j.ijcd.20200301.14

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    AMA Style

    Nadia Abdalhafid El Sherif, Salwa Abdalsalam El-Dibany. Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study. Int J Clin Dermatol. 2020;3(1):15-18. doi: 10.11648/j.ijcd.20200301.14

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  • @article{10.11648/j.ijcd.20200301.14,
      author = {Nadia Abdalhafid El Sherif and Salwa Abdalsalam El-Dibany},
      title = {Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study},
      journal = {International Journal of Clinical Dermatology},
      volume = {3},
      number = {1},
      pages = {15-18},
      doi = {10.11648/j.ijcd.20200301.14},
      url = {https://doi.org/10.11648/j.ijcd.20200301.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijcd.20200301.14},
      abstract = {Background: Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 2–3%. Psoriasis is caused by a complex interplay among the immune system, genetic background, auto-antigens, and environmental factors. Trace elements are required for the normal functioning of many enzymes and play a significant role in the development of many diseases. Objective: To assess the serum levels of zinc, copper, magnesium, iron and folate in patients with psoriasis compared to healthy controls. Patients and Methods: A total of 41 patients with psoriasis vulgaris were compared with 50 age and sex matched healthy subjects. Serum levels of zinc (Zn), copper (Cu), magnesium (Mg), iron (Fe) and folate were measured in both groups and compared. Psoriasis Area and Severity Index (PASI) were used to measure the severity of the disease. Results: The mean serum level of Zn was 142.2±52 in patients compared to 90.2±18.9 in the controls (P=.000), serum level of Cu was 161.1±58.5 in patients versus 156.3±42.8 in control group (P=.650). Serum Mg was 2.4±0.5 in patients and 1.9±0.2 in control subjects (P=.000). Serum Fe was 90.8±50 in patients as compared to 116.9±32.4 in control subjects (P=.004), whereas, serum folate was 6.6±3.9 in patients and 9.5±5.3 in control subjects (P=.005). There was no significant direct correlation between levels of trace elements under study and PASI scoring. Conclusions: Trace elements particularly Zn, Cu, and Mg appear to be elevated in psoriasis patients, while Fe and folate were low in psoriatic patients, however, they can't serve as biomarkers for disease activity.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study
    AU  - Nadia Abdalhafid El Sherif
    AU  - Salwa Abdalsalam El-Dibany
    Y1  - 2020/06/09
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijcd.20200301.14
    DO  - 10.11648/j.ijcd.20200301.14
    T2  - International Journal of Clinical Dermatology
    JF  - International Journal of Clinical Dermatology
    JO  - International Journal of Clinical Dermatology
    SP  - 15
    EP  - 18
    PB  - Science Publishing Group
    SN  - 2995-1305
    UR  - https://doi.org/10.11648/j.ijcd.20200301.14
    AB  - Background: Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 2–3%. Psoriasis is caused by a complex interplay among the immune system, genetic background, auto-antigens, and environmental factors. Trace elements are required for the normal functioning of many enzymes and play a significant role in the development of many diseases. Objective: To assess the serum levels of zinc, copper, magnesium, iron and folate in patients with psoriasis compared to healthy controls. Patients and Methods: A total of 41 patients with psoriasis vulgaris were compared with 50 age and sex matched healthy subjects. Serum levels of zinc (Zn), copper (Cu), magnesium (Mg), iron (Fe) and folate were measured in both groups and compared. Psoriasis Area and Severity Index (PASI) were used to measure the severity of the disease. Results: The mean serum level of Zn was 142.2±52 in patients compared to 90.2±18.9 in the controls (P=.000), serum level of Cu was 161.1±58.5 in patients versus 156.3±42.8 in control group (P=.650). Serum Mg was 2.4±0.5 in patients and 1.9±0.2 in control subjects (P=.000). Serum Fe was 90.8±50 in patients as compared to 116.9±32.4 in control subjects (P=.004), whereas, serum folate was 6.6±3.9 in patients and 9.5±5.3 in control subjects (P=.005). There was no significant direct correlation between levels of trace elements under study and PASI scoring. Conclusions: Trace elements particularly Zn, Cu, and Mg appear to be elevated in psoriasis patients, while Fe and folate were low in psoriatic patients, however, they can't serve as biomarkers for disease activity.
    VL  - 3
    IS  - 1
    ER  - 

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