Dopa-Responsive Dystonia with Diurnal Fluctuation: A Case Report of an 18 Year Old Nigerian
Clinical Neurology and Neuroscience
Volume 2, Issue 2, June 2018, Pages: 23-26
Received: Oct. 25, 2017; Accepted: Feb. 3, 2018; Published: Jul. 4, 2018
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Olusegun Adesola Busari, Department of Medicine, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
Paul Olowoyo, Department of Medicine, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
Segun Oladele Adeniyi, Department of Medicine, Landmark University Medical Centre, Omu-Aran, Nigeria
Bidemi Olayemi Onipede, Department of Medicine, Landmark University Medical Centre, Omu-Aran, Nigeria
Olisa Joseph, Department of Medicine, Landmark University Medical Centre, Omu-Aran, Nigeria
Solomon Ogunniran, Department of Medicine, Landmark University Medical Centre, Omu-Aran, Nigeria
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Dopa-responsive dystonia, also known as hereditary progressive dystonia with diurnal variation, is a genetic disease characterized by childhood or adolescent onset of dystonia and sometimes associated with parkinsonian features. This is a case report of an 18 year old Nigerian University undergraduate with features of difficulty in speaking, stiffness of the body, gait difficulties, coarse tremors and toe-walking. There was a very marked improvement of symptoms and signs within 24-48 hours of the commencement of SinemetTM (levodopa/ carbidopa) 125mg/12.5mg daily. The patient was discharged after 5 days with normal gait.
Dopa, Dystonia, Diurnal Variations, Levodopa/Carbidopa
To cite this article
Olusegun Adesola Busari, Paul Olowoyo, Segun Oladele Adeniyi, Bidemi Olayemi Onipede, Olisa Joseph, Solomon Ogunniran, Dopa-Responsive Dystonia with Diurnal Fluctuation: A Case Report of an 18 Year Old Nigerian, Clinical Neurology and Neuroscience. Vol. 2, No. 2, 2018, pp. 23-26. doi: 10.11648/j.cnn.20180202.11
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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