Atypical Femur Fractures: A Case Report and Literature Review
Clinical Neurology and Neuroscience
Volume 3, Issue 4, December 2019, Pages: 89-92
Received: Nov. 9, 2019; Accepted: Dec. 2, 2019; Published: Dec. 10, 2019
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Xiang Dian, Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China
Yang Yuhao, Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China
Lin Hongsheng, Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China
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With the aging of the global population, osteoporosis has become a widespread phenomenon in the society. With the rapid increase of the number of osteoporotic fractures, a huge social and economic pressure has been caused. At the same time, it has attracted extensive attention. Bisphosphonates (BPs) can effectively prevent bone loss, improve bone density, and effectively reduce the incidence of osteoporotic fracture in the vertebral body and hip, which is the first choice for the treatment of osteoporosis. However, after tens of thousands of people take bisphosphonates for a long time, there are more and more reports of atypical femoral fractures (AFFs) caused by bisphosphonates, which cause the concerns of patients and doctors. The long-term use of bisphosphonates can promote the apoptosis of osteoclasts, inhibit the osteoclast's dissolution and absorption of bone trabecula, then reduce bone turnover, inhibit bone remodeling, lead to the accumulation of bone micro damage, and finally lead to fracture AFFs. We present an 83 year old woman who has been taking bisphosphonates for more than 10 years. The images indicate that there is nonunion in the middle and upper segments of both femurs. She was diagnosed as bilateral AFFS and was treated with plate and screw internal fixation for the left femur fracture and temporary conservative treatment for the right femur fracture. She was treated with anti infection, analgesia and circulation improvement after operation and the symptoms were relieved obviously and the effect was satisfactory. The case was reported as follows and reviews the related literature.
Atypical Femoral Fractures, Bisphosphonates, Osteoporosis
To cite this article
Xiang Dian, Yang Yuhao, Lin Hongsheng, Atypical Femur Fractures: A Case Report and Literature Review, Clinical Neurology and Neuroscience. Vol. 3, No. 4, 2019, pp. 89-92. doi: 10.11648/j.cnn.20190304.14
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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