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Bacteria and Antibiotic Susceptibility Patterns of Cerebrospinal Fluid Isolated in Children with Bacterial Meningitis at Sanglah Hospital, Bali from 2016 to 2018
Clinical Neurology and Neuroscience
Volume 4, Issue 3, September 2020, Pages: 51-56
Received: Jun. 22, 2020; Accepted: Jul. 14, 2020; Published: Jul. 28, 2020
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Gina Henny Kristianti, Department of Child Health, Medical Faculty of Udayana University, Denpasar, Indonesia
I Gusti Ngurah Made Suwarba, Department of Child Health, Medical Faculty of Udayana University, Denpasar, Indonesia
Dewi Sutriani Mahalini, Department of Child Health, Medical Faculty of Udayana University, Denpasar, Indonesia
I Wayan Gustawan, Department of Child Health, Medical Faculty of Udayana University, Denpasar, Indonesia
I Made Gede Dwi Lingga Utama, Department of Child Health, Medical Faculty of Udayana University, Denpasar, Indonesia
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Periodic review from laboratory about the pathogens causing the bacterial meningitis and its antimicrobial sensitivity test result is important to determine the most common etiology of meningitis, since they can be varied according to time, geography, and patient’s age. This study is a retrospective descriptive study. Affordable population in this study was children with positive cerebrospinal fluid culture results who were treated in Pediatric ward at Sanglah hospital, Denpasar from January 1st, 2016 until December 31st, 2018. The study used secondary data from the microbiology register in Clinical Microbiology Laboratory and medical record of Sanglah Hospital. This study employed total sampling method to collect samples. There were 52 samples that obtained in this study. Most of them were gram negative bacteria (53.8%). The most common gram negative bacteria found were Pseudomonas sp, with Pseudomonas stutzeri. The most common gram positive bacteria found were Staphylococcus sp, with Staphylococcus hemolitikus. Vancomycin, Linezolid and Tigecyclin have high sensitivity against gram positive bacteria. Carbapenem, aminoglycoside and fourth generation of cephalosporine still had high sensitivity against gram negative bacteria. About 26.9% of bacterias were multidrug resistant organisms (MDRO) and most of them (78.6%) were gram positive. Ceftriaxone as our empirical therapy has low sensitivity (30%) to gram positive bacteria and moderate sensitivity to gram negative bacteria (53.57%). Resistance to cephalosporin might be quite high in this particular clinical setting due to high number of MDRO. It should be taken into account before giving treatment for bacterial meningitis.
Bacterial Meningitis, Culture Sensitivity, Children
To cite this article
Gina Henny Kristianti, I Gusti Ngurah Made Suwarba, Dewi Sutriani Mahalini, I Wayan Gustawan, I Made Gede Dwi Lingga Utama, Bacteria and Antibiotic Susceptibility Patterns of Cerebrospinal Fluid Isolated in Children with Bacterial Meningitis at Sanglah Hospital, Bali from 2016 to 2018, Clinical Neurology and Neuroscience. Vol. 4, No. 3, 2020, pp. 51-56. doi: 10.11648/j.cnn.20200403.12
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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