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Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting

Received: 17 October 2020    Accepted: 2 November 2020    Published: 11 November 2020
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Abstract

Background: Male infertility is defined as a lack of pregnancy for a couple after 12 months of regular and normal sexual intercourse without contraception with the cause being clearly from the male origin. Contrary to popular belief, the prevalence of male infertility is similar to that of female infertility and sometimes even higher. However, data on the subject in Cameron are scarce and nonexistent in the city of Douala. This motivated the realization of this study in two centers in the city of Douala. The objective was to describe the epidemiological profile of male infertility. Methods: We conducted a cross-sectional study among patients who consulted for infertility in two hospital centers in Douala from January 2014 to October 2019. A consecutive sample of all eligible cases was considered for this study. Data were analyzed using Statistical Package for Social Sciences (SPSS Inc, Chicago, Illinois, USA) V. 20.0 and EPI-INFO V. 3.5 software. Analyzed variables included sociodemographic data (age, marital status, educational level, profession, region, alcohol, smoking habit and mean infertility duration) and other causes of infertility (obesity, history of testes infection, STI, testes traumatism, varicocele or varicocele surgery, herniorrhaphy, genetic or malformative disease). Results: We included 137 patients' records. The frequency of male infertility for patients consulting in urology was 5.6%. Their average age was 35.4±7.4 years. The average number of sexual intercourses per week was 2.7±0.97. Those patients were mainly from an intellectual profession (40.2%), married (71.5%) with a higher education level (67.2%). Almost 60% of the studied population had alcohol consumption. Primary infertility accounted for 65.7% of the study population and the average duration of infertility was 5.9±5.3 years. The main factors for infertility were respectively history of sexually transmitted infections (STI) in 59 (43.1%) and childhood mumps in 42 (32.7%) cases. Furthermore, herniorrhaphy (16.1%) and varicocelectomy (10.9%) were the most representative surgical background. Conclusion: Male infertility is not uncommon in urological consultation with primary infertility been more frequent. Risk factors of infertility in our setting included a history of STI, mumps, and surgery.

Published in International Journal of Clinical Urology (Volume 4, Issue 2)
DOI 10.11648/j.ijcu.20200402.22
Page(s) 85-91
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Epidemiology, Male Infertility, Sub-Saharan Africa Setting

References
[1] Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 009; 92 (5): 1520-4.
[2] Jungwirth A, Diemer T, Kopa Z, Krausz C, Minhas S, Tournaye H. European Association of Urology guidelines on male infertility. Arnhem, The Netherlands: European Association of Urology; 2018 p. 1-47.
[3] Brzakowski M, Lourdel E, Cabry R, Oliéric M-F, Claeys C, Devaux A, et al. Épidémiologie du couple infertile. J Gynécologie Obstétrique Biol Reprod. 2009; 38: F3-7.
[4] Oakley L, Doyle P, Maconochie N. Lifetime prevalence of infertility and infertility treatment in the UK: results from a population-based survey of reproduction. Hum Reprod Oxf Engl. 2008; 23 (2): 447-50.
[5] Zhou Z, Zheng D, Wu H, Li R, Xu S, Kang Y, et al. Epidemiology of infertility in China: a population-based study. BJOG Int J Obstet Gynaecol. 2018; 125 (4): 432-41.
[6] Chandra A, Copen CE, Stephen EH. Infertility and impaired fecundity in the United States, 1982-2010: data from the National Survey of Family Growth. Natl Health Stat Rep. 2013; (67): 1-18, 1 p following 19.
[7] Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015; 13 (1): 37.
[8] Velu A, Prasad G. Epidemiologic aspects of male infertility. Int J Reprod Contracept Obstet Gynecol. 2017; 6 (8): 3362.
[9] Alam J, Choudhary P, Aslam M. Prospective study to evaluate the risk factors associated with male infertility at tertiary care centre. Int Surg J. 2018; 5 (8): 2862.
[10] Cong J, Li P, Zheng L, Tan J. Prevalence and Risk Factors of Infertility at a Rural Site of Northern China. Handelsman DJ, éditeur. PLOS ONE. 2016; 11 (5): e0155563.
[11] Sohrabvand F, Jafari M, Shariat M, Haghollahi F, Lotfi M. Frequency and epidemiologic aspects of male infertility. Acta Med Iran. 2015; 53 (4): 231-5.
[12] Aziz N, Agarwal A, Nallella KP, Thomas Jr AJ. Relationship between epidemiological features and aetiology of male infertility as diagnosed by a comprehensive infertility service provider. Reprod Biomed Online. 2006; 12 (2): 209-14.
[13] Olatunji AO, Sule-Odu AO. The pattern of infertility cases at a University Hospital. West Afr J Med. 1 janv 2003; 22 (3): 205-207.
[14] Gyasi-Sarpong C, Manu Maison P, Koranteng A. The pattern of male infertility in Kumasi, Ghana. Afr J Infertil Assist Concept. 2017; 2 (1): 3.
[15] Nana PN, Wandji JC, Fomulu JN, Mbu RE, Leke RJI, Woubinwou MJ. Aspects Psycho-Sociaux chez Patients Infertiles à la Maternite Principale de l’Hopital Central de Yaoundé, Cameroun. Clin Mother Child Health. 2011; 8: 1-5.
[16] Voundi Voundi E, Cyrille Noa Ndoua C, Belinga E, Ndoumba AM, Emmanuel Voundi Voundi J, Toukam M, et al. Factors Associated with Spermatic Abnormalities in Men Consulting for Couple Infertility at the Hospital Center for Research and Application in Endoscopic Surgery and Human Reproduction, Cameroon. Int Ann Med. 2018; 2 (11):. Disponible sur: https://iamresearcher.online/ojs/index.php/iam/article/view/661
[17] Benazzouz MH, Essatara Y, Sayegh HE, Iken A, Benslimane L, Nouini Y. Impact de la varicocèle sur le volume testiculaire et les paramètres spermatiques. Pan Afr Med J. 2014; 19: 1-8. Disponible sur: http://www.panafrican-med-journal.com/content/article/19/334/full/.
[18] Institut National de la Statitisque et des Etudes Economiques (INSEE). NOMENCLATURE DES PROFESSIONS ET CATEGORIES SOCIOPROFESSIONNELLES. Paris; 2016 p. 666. Report No.: 3è édition, 2003. Available at: https://www.insee.fr/fr/metadonnees/pcs2003/categorieSocioprofessionnelleAgregee/4?champRecherche=false.
[19] Diallo AB, Bah I, Barry M, Diallo TMO, Bah MD, Kanté D, et al. La varicocèle de l’adulte: aspects anatomo-cliniques et resultats therapeutiques au service d’urologie-andrologie du CHU de Conakry, Guinee. Afr J Urol. 2015; 21 (2): 137–141.
[20] Moussa D, Soumana A, Amadou SM, Soli I, Tahirou I, Ali A. Profil hormonal chez l’homme en cas d’infertilité au laboratoire de radio immunologie de l’institut des radioisotopes de Niamey. Afr J Urol. 2016; 22 (4): 305-309-309.
[21] Tijani KH, Oyende BO, Awosanya GO, Ojewola RW, Lawal AO, Yusuf AO. Scrotal abnormalities and infertility in west African men: A comparison of fertile and sub-fertile men using scrotal ultrasonography. Afr J Urol. 2014; 20 (4): 180-3.
[22] Okonofua F, Menakaya U, Onemu SO, Omo-Aghoja LO, Bergstrom S. A case-control study of risk factors for male infertility in Nigeria. Asian J Androl. 2005; 7 (4): 351-61.
[23] Uadia PO, Emokpae AM. Male infertility in Nigeria: A neglected reproductive health issue requiring attention. J Basic Clin Reprod Sci. 2015; 4 (2): 45-53-53.
[24] Martin-Odoom A, Brown CA, Adjei DN. Level of male infertility in the Ghanaian city of Tema. J Obstet Gynaecol J Inst Obstet Gynaecol. 2015; 35 (8): 825-8.
[25] Kirakoya B, Barnabé Z, Karim PA, Aristide KF, Clotaire Y, Amélie N. Epidemiological and Clinical Profile of Male Hypofertility in Consultation at the Urology-Andrology of Yalgado Ouedraogo Teaching Hospital (Burkina Faso). Adv Sex Med. 2014; 5 (1): 1-6.
[26] Bah OR, Diallo AB, Diallo A, Guirassy S, Bah I, Barry M, et al. Infertilité masculine: frdquence et aspects étiologiques au service d’Urologie-Andrologie du CHU de Conakry. Andrologie. 2007; 17 (3): 241-5.
[27] Sari-Minodier I, Loundou A, Ianos O, Ould Hamouda S, De Fleurian G, Lacroix-Paulmyer O, et al. Exposition professionnelle des hommes infertiles aux reprotoxiques: données du CHU de Marseille. Arch Mal Prof Environ. 2018; 79 (3): 300-1.
[28] Punab M, Poolamets O, Paju P, Vihljajev V, Pomm K, Ladva R, et al. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Hum Reprod. 17 2016; humrep; dew284v1.
[29] Niang L, Ndoye M, Labou I, Jalloh M, Kane R, Diaw JJ, et al. Profil épidémiologique et clinique de l’infertilité masculine à l’hôpital général de Grand-Yoff, Sénégal: à propos de 492 cas. Basic Clin Androl. 2009; 19 (2): 103-7.
[30] Traore M, Toure A, Sissoko S, Samake NF. Profil spermiologique des hommes infertiles au Mali. Andrologie. 2008; 18 (4): 253-7.
[31] Benbella A, Aboulmakarim S, Hardizi H, Zaidouni A, Bezad R. Infertility in the Moroccan population: an etiological study in the reproductive health centre in Rabat. Pan Afr Med J. 2018; 30: 204.
[32] Nwajiaku LA, Mbachu IL, Ikealo L. Prevalence, Clinical Pattern and Major Causes of Male Infertility in Nnewi, South East Nigeria: A Five-Year Review. AFRIMEDIC J. 2012; 3 (2): 16-9.
[33] Marinelli D, Gaspari L, Pedotti P, Taioli E. Mini-review of studies on the effect of smoking and drinking habits on semen parameters. Int J Hyg Environ Health. 2004; 207 (3): 185-92.
[34] Zorn B. Le sperme «inflammatoire»: ses relations avec la fertilité. Andrologie. 2009; 19 (1): 35-44.
[35] Association Médicale Mondiale. Déclaration d’Helsinki de l’Association Médicale Mondiale: principes éthiques applicables aux recherches médicales sur des sujets humains. 2013. Disponible sur: https://www.wma.net/fr/policies-post/declaration-dhelsinki-de-lamm-principes-ethiques-applicables-a-la-recherche-medicale-impliquant-des-etres-humains/.
Cite This Article
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    Frantz Guy Epoupa Ngalle, Kelly Donfack, Edouard Herve Moby Mpah, Sylvain Raoul Simeni Njonnou, Charlotte Tchente Nguefack. (2020). Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting. International Journal of Clinical Urology, 4(2), 85-91. https://doi.org/10.11648/j.ijcu.20200402.22

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    ACS Style

    Frantz Guy Epoupa Ngalle; Kelly Donfack; Edouard Herve Moby Mpah; Sylvain Raoul Simeni Njonnou; Charlotte Tchente Nguefack. Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting. Int. J. Clin. Urol. 2020, 4(2), 85-91. doi: 10.11648/j.ijcu.20200402.22

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    AMA Style

    Frantz Guy Epoupa Ngalle, Kelly Donfack, Edouard Herve Moby Mpah, Sylvain Raoul Simeni Njonnou, Charlotte Tchente Nguefack. Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting. Int J Clin Urol. 2020;4(2):85-91. doi: 10.11648/j.ijcu.20200402.22

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  • @article{10.11648/j.ijcu.20200402.22,
      author = {Frantz Guy Epoupa Ngalle and Kelly Donfack and Edouard Herve Moby Mpah and Sylvain Raoul Simeni Njonnou and Charlotte Tchente Nguefack},
      title = {Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting},
      journal = {International Journal of Clinical Urology},
      volume = {4},
      number = {2},
      pages = {85-91},
      doi = {10.11648/j.ijcu.20200402.22},
      url = {https://doi.org/10.11648/j.ijcu.20200402.22},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcu.20200402.22},
      abstract = {Background: Male infertility is defined as a lack of pregnancy for a couple after 12 months of regular and normal sexual intercourse without contraception with the cause being clearly from the male origin. Contrary to popular belief, the prevalence of male infertility is similar to that of female infertility and sometimes even higher. However, data on the subject in Cameron are scarce and nonexistent in the city of Douala. This motivated the realization of this study in two centers in the city of Douala. The objective was to describe the epidemiological profile of male infertility. Methods: We conducted a cross-sectional study among patients who consulted for infertility in two hospital centers in Douala from January 2014 to October 2019. A consecutive sample of all eligible cases was considered for this study. Data were analyzed using Statistical Package for Social Sciences (SPSS Inc, Chicago, Illinois, USA) V. 20.0 and EPI-INFO V. 3.5 software. Analyzed variables included sociodemographic data (age, marital status, educational level, profession, region, alcohol, smoking habit and mean infertility duration) and other causes of infertility (obesity, history of testes infection, STI, testes traumatism, varicocele or varicocele surgery, herniorrhaphy, genetic or malformative disease). Results: We included 137 patients' records. The frequency of male infertility for patients consulting in urology was 5.6%. Their average age was 35.4±7.4 years. The average number of sexual intercourses per week was 2.7±0.97. Those patients were mainly from an intellectual profession (40.2%), married (71.5%) with a higher education level (67.2%). Almost 60% of the studied population had alcohol consumption. Primary infertility accounted for 65.7% of the study population and the average duration of infertility was 5.9±5.3 years. The main factors for infertility were respectively history of sexually transmitted infections (STI) in 59 (43.1%) and childhood mumps in 42 (32.7%) cases. Furthermore, herniorrhaphy (16.1%) and varicocelectomy (10.9%) were the most representative surgical background. Conclusion: Male infertility is not uncommon in urological consultation with primary infertility been more frequent. Risk factors of infertility in our setting included a history of STI, mumps, and surgery.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting
    AU  - Frantz Guy Epoupa Ngalle
    AU  - Kelly Donfack
    AU  - Edouard Herve Moby Mpah
    AU  - Sylvain Raoul Simeni Njonnou
    AU  - Charlotte Tchente Nguefack
    Y1  - 2020/11/11
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijcu.20200402.22
    DO  - 10.11648/j.ijcu.20200402.22
    T2  - International Journal of Clinical Urology
    JF  - International Journal of Clinical Urology
    JO  - International Journal of Clinical Urology
    SP  - 85
    EP  - 91
    PB  - Science Publishing Group
    SN  - 2640-1355
    UR  - https://doi.org/10.11648/j.ijcu.20200402.22
    AB  - Background: Male infertility is defined as a lack of pregnancy for a couple after 12 months of regular and normal sexual intercourse without contraception with the cause being clearly from the male origin. Contrary to popular belief, the prevalence of male infertility is similar to that of female infertility and sometimes even higher. However, data on the subject in Cameron are scarce and nonexistent in the city of Douala. This motivated the realization of this study in two centers in the city of Douala. The objective was to describe the epidemiological profile of male infertility. Methods: We conducted a cross-sectional study among patients who consulted for infertility in two hospital centers in Douala from January 2014 to October 2019. A consecutive sample of all eligible cases was considered for this study. Data were analyzed using Statistical Package for Social Sciences (SPSS Inc, Chicago, Illinois, USA) V. 20.0 and EPI-INFO V. 3.5 software. Analyzed variables included sociodemographic data (age, marital status, educational level, profession, region, alcohol, smoking habit and mean infertility duration) and other causes of infertility (obesity, history of testes infection, STI, testes traumatism, varicocele or varicocele surgery, herniorrhaphy, genetic or malformative disease). Results: We included 137 patients' records. The frequency of male infertility for patients consulting in urology was 5.6%. Their average age was 35.4±7.4 years. The average number of sexual intercourses per week was 2.7±0.97. Those patients were mainly from an intellectual profession (40.2%), married (71.5%) with a higher education level (67.2%). Almost 60% of the studied population had alcohol consumption. Primary infertility accounted for 65.7% of the study population and the average duration of infertility was 5.9±5.3 years. The main factors for infertility were respectively history of sexually transmitted infections (STI) in 59 (43.1%) and childhood mumps in 42 (32.7%) cases. Furthermore, herniorrhaphy (16.1%) and varicocelectomy (10.9%) were the most representative surgical background. Conclusion: Male infertility is not uncommon in urological consultation with primary infertility been more frequent. Risk factors of infertility in our setting included a history of STI, mumps, and surgery.
    VL  - 4
    IS  - 2
    ER  - 

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Author Information
  • Department of Surgery, Douala General Hospital, Douala, Cameroon; Department of Surgery, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Department of Surgery, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Department of Surgery, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon; Nkongsamba Regional Hospital, Nkongsamba, Cameroon

  • Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon

  • Department of Surgery, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon; Department of Gynaecology, Douala General Hospital, Douala, Cameroon

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