Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer

Ahmed Mohammed Morsy; Eman Ahmed Hasan; Ameer Mohammed Abuelgheet; Ahmed Salaheldeen Hassan

doi:doi:10.11648/j.ijcocr.20160101.16

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Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer

Ahmed Mohammed Morsy, Eman Ahmed Hasan, Ameer Mohammed Abuelgheet, Ahmed Salaheldeen Hassan

Published in International Journal of Clinical Oncology and Cancer Research (Volume 1, Issue 1)

Received: 20 December 2016 Accepted: 30 December 2016 Published: 17 January 2017

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Abstract

Environmentally-induced epigenetic changes of gene regulation could result from chronic, lifelong exposure, to low doses of environmental toxicants, such as chemicals including, tobacco smoking and endocrine disrupting compounds, or to other environmental factors such as nutritional changes, and lifestyle-related conditions. These environmentally-acquired epigenetic marks may influence the control of gene regulation through DNA methylation, histone modification, or through a large set of non-coding RNAs (ncRNAs). These epigenetic effects might be passed on to the developing embryo and child as inheritable non-genetic marks, which recapitulate previous lifelong history of exposure to environmental influences that start from the stage of primordial germ cell, passing through the maturing germ cell, and ending by the zygote stage. This involves the paternally transmitted information on the sperm that contribute to modulating embryogenesis functions and later childhood development, in concert with, the maternally transmitted information encountered by the exposure to a large milieu of environmental factors either periconceptionally or during lactation period.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 1, Issue 1)
DOI	10.11648/j.ijcocr.20160101.16
Page(s)	36-41
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pediatric Oncology, Childhood Cancer, Epigenetics, Environmental Exposures, Epigenetic Inheritance & Evolution, Pediatric Cancer Susceptibility

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APA Style

Ahmed Mohammed Morsy, Eman Ahmed Hasan, Ameer Mohammed Abuelgheet, Ahmed Salaheldeen Hassan. (2017). Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer. International Journal of Clinical Oncology and Cancer Research, 1(1), 36-41. https://doi.org/10.11648/j.ijcocr.20160101.16

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ACS Style

Ahmed Mohammed Morsy; Eman Ahmed Hasan; Ameer Mohammed Abuelgheet; Ahmed Salaheldeen Hassan. Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer. Int. J. Clin. Oncol. Cancer Res. 2017, 1(1), 36-41. doi: 10.11648/j.ijcocr.20160101.16

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AMA Style

Ahmed Mohammed Morsy, Eman Ahmed Hasan, Ameer Mohammed Abuelgheet, Ahmed Salaheldeen Hassan. Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer. Int J Clin Oncol Cancer Res. 2017;1(1):36-41. doi: 10.11648/j.ijcocr.20160101.16

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@article{10.11648/j.ijcocr.20160101.16,
  author = {Ahmed Mohammed Morsy and Eman Ahmed Hasan and Ameer Mohammed Abuelgheet and Ahmed Salaheldeen Hassan},
  title = {Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {1},
  number = {1},
  pages = {36-41},
  doi = {10.11648/j.ijcocr.20160101.16},
  url = {https://doi.org/10.11648/j.ijcocr.20160101.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20160101.16},
  abstract = {Environmentally-induced epigenetic changes of gene regulation could result from chronic, lifelong exposure, to low doses of environmental toxicants, such as chemicals including, tobacco smoking and endocrine disrupting compounds, or to other environmental factors such as nutritional changes, and lifestyle-related conditions. These environmentally-acquired epigenetic marks may influence the control of gene regulation through DNA methylation, histone modification, or through a large set of non-coding RNAs (ncRNAs). These epigenetic effects might be passed on to the developing embryo and child as inheritable non-genetic marks, which recapitulate previous lifelong history of exposure to environmental influences that start from the stage of primordial germ cell, passing through the maturing germ cell, and ending by the zygote stage. This involves the paternally transmitted information on the sperm that contribute to modulating embryogenesis functions and later childhood development, in concert with, the maternally transmitted information encountered by the exposure to a large milieu of environmental factors either periconceptionally or during lactation period.},
 year = {2017}
}

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TY  - JOUR
T1  - Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer
AU  - Ahmed Mohammed Morsy
AU  - Eman Ahmed Hasan
AU  - Ameer Mohammed Abuelgheet
AU  - Ahmed Salaheldeen Hassan
Y1  - 2017/01/17
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcocr.20160101.16
DO  - 10.11648/j.ijcocr.20160101.16
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 36
EP  - 41
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20160101.16
AB  - Environmentally-induced epigenetic changes of gene regulation could result from chronic, lifelong exposure, to low doses of environmental toxicants, such as chemicals including, tobacco smoking and endocrine disrupting compounds, or to other environmental factors such as nutritional changes, and lifestyle-related conditions. These environmentally-acquired epigenetic marks may influence the control of gene regulation through DNA methylation, histone modification, or through a large set of non-coding RNAs (ncRNAs). These epigenetic effects might be passed on to the developing embryo and child as inheritable non-genetic marks, which recapitulate previous lifelong history of exposure to environmental influences that start from the stage of primordial germ cell, passing through the maturing germ cell, and ending by the zygote stage. This involves the paternally transmitted information on the sperm that contribute to modulating embryogenesis functions and later childhood development, in concert with, the maternally transmitted information encountered by the exposure to a large milieu of environmental factors either periconceptionally or during lactation period.
VL  - 1
IS  - 1
ER  -

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Author Information

Ahmed Mohammed Morsy

Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
Eman Ahmed Hasan

Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
Ameer Mohammed Abuelgheet

Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt
Ahmed Salaheldeen Hassan

Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

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APA Style

Ahmed Mohammed Morsy, Eman Ahmed Hasan, Ameer Mohammed Abuelgheet, Ahmed Salaheldeen Hassan. (2017). Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer. International Journal of Clinical Oncology and Cancer Research, 1(1), 36-41. https://doi.org/10.11648/j.ijcocr.20160101.16

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ACS Style

Ahmed Mohammed Morsy; Eman Ahmed Hasan; Ameer Mohammed Abuelgheet; Ahmed Salaheldeen Hassan. Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer. Int. J. Clin. Oncol. Cancer Res. 2017, 1(1), 36-41. doi: 10.11648/j.ijcocr.20160101.16

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AMA Style

Ahmed Mohammed Morsy, Eman Ahmed Hasan, Ameer Mohammed Abuelgheet, Ahmed Salaheldeen Hassan. Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer. Int J Clin Oncol Cancer Res. 2017;1(1):36-41. doi: 10.11648/j.ijcocr.20160101.16

Copy | Download

@article{10.11648/j.ijcocr.20160101.16,
  author = {Ahmed Mohammed Morsy and Eman Ahmed Hasan and Ameer Mohammed Abuelgheet and Ahmed Salaheldeen Hassan},
  title = {Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {1},
  number = {1},
  pages = {36-41},
  doi = {10.11648/j.ijcocr.20160101.16},
  url = {https://doi.org/10.11648/j.ijcocr.20160101.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20160101.16},
  abstract = {Environmentally-induced epigenetic changes of gene regulation could result from chronic, lifelong exposure, to low doses of environmental toxicants, such as chemicals including, tobacco smoking and endocrine disrupting compounds, or to other environmental factors such as nutritional changes, and lifestyle-related conditions. These environmentally-acquired epigenetic marks may influence the control of gene regulation through DNA methylation, histone modification, or through a large set of non-coding RNAs (ncRNAs). These epigenetic effects might be passed on to the developing embryo and child as inheritable non-genetic marks, which recapitulate previous lifelong history of exposure to environmental influences that start from the stage of primordial germ cell, passing through the maturing germ cell, and ending by the zygote stage. This involves the paternally transmitted information on the sperm that contribute to modulating embryogenesis functions and later childhood development, in concert with, the maternally transmitted information encountered by the exposure to a large milieu of environmental factors either periconceptionally or during lactation period.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer
AU  - Ahmed Mohammed Morsy
AU  - Eman Ahmed Hasan
AU  - Ameer Mohammed Abuelgheet
AU  - Ahmed Salaheldeen Hassan
Y1  - 2017/01/17
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcocr.20160101.16
DO  - 10.11648/j.ijcocr.20160101.16
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 36
EP  - 41
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20160101.16
AB  - Environmentally-induced epigenetic changes of gene regulation could result from chronic, lifelong exposure, to low doses of environmental toxicants, such as chemicals including, tobacco smoking and endocrine disrupting compounds, or to other environmental factors such as nutritional changes, and lifestyle-related conditions. These environmentally-acquired epigenetic marks may influence the control of gene regulation through DNA methylation, histone modification, or through a large set of non-coding RNAs (ncRNAs). These epigenetic effects might be passed on to the developing embryo and child as inheritable non-genetic marks, which recapitulate previous lifelong history of exposure to environmental influences that start from the stage of primordial germ cell, passing through the maturing germ cell, and ending by the zygote stage. This involves the paternally transmitted information on the sperm that contribute to modulating embryogenesis functions and later childhood development, in concert with, the maternally transmitted information encountered by the exposure to a large milieu of environmental factors either periconceptionally or during lactation period.
VL  - 1
IS  - 1
ER  -

Copy | Download