Background: Esophageal carcinoma (EC) is rare and little is known about them in Egypt. Gharbia population-based cancer registry (GPBCR) is the first population-based cancer registry in Egypt located in the Tanta Cancer Center (TCC). It has been successfully functioning since January 1999, covering 4.1 million population. We aimed to determine EC characteristics in Egyptian patients. Materials and methods: Retrospective analysis of 70 cases with ECs, who were identified in GPBCR between January 2000 and December 2002; of whom 35 were treated at TCC. Patients’ medical records were reviewed regarding clinic-epidemiologic, treatment, and follow-up data. Results: Median age was 60 years (range, 18-83 years) with male predominance (63%). Dysphagia was the most common presentation (75%). The lower third was the commonest site (55%) followed by the middle third (25%). Squamous cell carcinoma (SCC) was the commonest histology (66%) followed by adenocarcinoma (AC; 24%). Majority of ACs (70%) were located in the lower esophagus while SCC had no site of preference (p=0.04). Less than one third of patients were candidates for radical treatment while the majority of patients received palliative and supportive treatment. Surgery, radiotherapy and chemotherapy were employed in 43%, 20%, and 34% of patients respectively. The median progression-free survival and overall survival were 6 and 7 months, respectively. Site, histology, stage and treatment modality had no significant impact on survival. Conclusions: Esophageal carcinoma in Gharbia Governorate, Egypt is characterized by predominance of male gender, lower third location and squamous histology. Overall and progression free survivals are dismal.
| Published in | International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 1) |
| DOI | 10.11648/j.ijcocr.20170201.14 |
| Page(s) | 15-21 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Egypt, Gharbia Population-Based Cancer Registry, Esophageal Cancer
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APA Style
Ahmed Abdelmabood Zeeneldin, Magdy Saber, Ashraf Hamed Hassouna, Sara Ahmed Farag. (2017). Esophageal Carcinoma in El-Gharbia Governorate, Egypt: Clinico-Epidemiologic Study and Treatment Outcome. International Journal of Clinical Oncology and Cancer Research, 2(1), 15-21. https://doi.org/10.11648/j.ijcocr.20170201.14
ACS Style
Ahmed Abdelmabood Zeeneldin; Magdy Saber; Ashraf Hamed Hassouna; Sara Ahmed Farag. Esophageal Carcinoma in El-Gharbia Governorate, Egypt: Clinico-Epidemiologic Study and Treatment Outcome. Int. J. Clin. Oncol. Cancer Res. 2017, 2(1), 15-21. doi: 10.11648/j.ijcocr.20170201.14
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Download@article{10.11648/j.ijcocr.20170201.14,
author = {Ahmed Abdelmabood Zeeneldin and Magdy Saber and Ashraf Hamed Hassouna and Sara Ahmed Farag},
title = {Esophageal Carcinoma in El-Gharbia Governorate, Egypt: Clinico-Epidemiologic Study and Treatment Outcome},
journal = {International Journal of Clinical Oncology and Cancer Research},
volume = {2},
number = {1},
pages = {15-21},
doi = {10.11648/j.ijcocr.20170201.14},
url = {https://doi.org/10.11648/j.ijcocr.20170201.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170201.14},
abstract = {Background: Esophageal carcinoma (EC) is rare and little is known about them in Egypt. Gharbia population-based cancer registry (GPBCR) is the first population-based cancer registry in Egypt located in the Tanta Cancer Center (TCC). It has been successfully functioning since January 1999, covering 4.1 million population. We aimed to determine EC characteristics in Egyptian patients. Materials and methods: Retrospective analysis of 70 cases with ECs, who were identified in GPBCR between January 2000 and December 2002; of whom 35 were treated at TCC. Patients’ medical records were reviewed regarding clinic-epidemiologic, treatment, and follow-up data. Results: Median age was 60 years (range, 18-83 years) with male predominance (63%). Dysphagia was the most common presentation (75%). The lower third was the commonest site (55%) followed by the middle third (25%). Squamous cell carcinoma (SCC) was the commonest histology (66%) followed by adenocarcinoma (AC; 24%). Majority of ACs (70%) were located in the lower esophagus while SCC had no site of preference (p=0.04). Less than one third of patients were candidates for radical treatment while the majority of patients received palliative and supportive treatment. Surgery, radiotherapy and chemotherapy were employed in 43%, 20%, and 34% of patients respectively. The median progression-free survival and overall survival were 6 and 7 months, respectively. Site, histology, stage and treatment modality had no significant impact on survival. Conclusions: Esophageal carcinoma in Gharbia Governorate, Egypt is characterized by predominance of male gender, lower third location and squamous histology. Overall and progression free survivals are dismal.},
year = {2017}
}
TY - JOUR T1 - Esophageal Carcinoma in El-Gharbia Governorate, Egypt: Clinico-Epidemiologic Study and Treatment Outcome AU - Ahmed Abdelmabood Zeeneldin AU - Magdy Saber AU - Ashraf Hamed Hassouna AU - Sara Ahmed Farag Y1 - 2017/03/02 PY - 2017 N1 - https://doi.org/10.11648/j.ijcocr.20170201.14 DO - 10.11648/j.ijcocr.20170201.14 T2 - International Journal of Clinical Oncology and Cancer Research JF - International Journal of Clinical Oncology and Cancer Research JO - International Journal of Clinical Oncology and Cancer Research SP - 15 EP - 21 PB - Science Publishing Group SN - 2578-9511 UR - https://doi.org/10.11648/j.ijcocr.20170201.14 AB - Background: Esophageal carcinoma (EC) is rare and little is known about them in Egypt. Gharbia population-based cancer registry (GPBCR) is the first population-based cancer registry in Egypt located in the Tanta Cancer Center (TCC). It has been successfully functioning since January 1999, covering 4.1 million population. We aimed to determine EC characteristics in Egyptian patients. Materials and methods: Retrospective analysis of 70 cases with ECs, who were identified in GPBCR between January 2000 and December 2002; of whom 35 were treated at TCC. Patients’ medical records were reviewed regarding clinic-epidemiologic, treatment, and follow-up data. Results: Median age was 60 years (range, 18-83 years) with male predominance (63%). Dysphagia was the most common presentation (75%). The lower third was the commonest site (55%) followed by the middle third (25%). Squamous cell carcinoma (SCC) was the commonest histology (66%) followed by adenocarcinoma (AC; 24%). Majority of ACs (70%) were located in the lower esophagus while SCC had no site of preference (p=0.04). Less than one third of patients were candidates for radical treatment while the majority of patients received palliative and supportive treatment. Surgery, radiotherapy and chemotherapy were employed in 43%, 20%, and 34% of patients respectively. The median progression-free survival and overall survival were 6 and 7 months, respectively. Site, histology, stage and treatment modality had no significant impact on survival. Conclusions: Esophageal carcinoma in Gharbia Governorate, Egypt is characterized by predominance of male gender, lower third location and squamous histology. Overall and progression free survivals are dismal. VL - 2 IS - 1 ER -
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