Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products
International Journal of Clinical Oncology and Cancer Research
Volume 2, Issue 2, April 2017, Pages: 31-44
Received: Feb. 9, 2017; Accepted: Mar. 1, 2017; Published: Mar. 20, 2017
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Hayder M. Alkuraishy, Department of Clinical Pharmacology and Therapeutic, Medical Faculty, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq
Ali I. Al-Gareeb, Department of Clinical Pharmacology and Therapeutic, Medical Faculty, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq
Hany Akeel Al-hussaniy, Bsc Pharmacist, Ministry of Health, Baghdad, Iraq
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Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-induced cardiotoxicity. Doxorubicin therapy augments oxidative stress and disturbs cytosolic calcium homeostasis, increases intracellular calcium levels from the sarcoplasmic reticulum through activation of the ryanodine receptor and by blighting calcium clearance systems in cardiomyocytes. In this condition the researchers trying to develop cardio-protective strategy to decrease this cardio-toxic effect without decreasing its anticancer effect. Now day's oncologists and pharmacologist work to find out how to decrease the cardiovascular risk and prevent doxorubicin adverse cardiovascular effect. Therefore, the aim of this study was to illustrate the molecular mechanism and possible amelioration of doxorubicin induced-cardiotoxicity via conventional drugs and natural products.
Doxorubicin, Cardiotoxicity, Natural Products
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Hayder M. Alkuraishy, Ali I. Al-Gareeb, Hany Akeel Al-hussaniy, Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products, International Journal of Clinical Oncology and Cancer Research. Vol. 2, No. 2, 2017, pp. 31-44. doi: 10.11648/j.ijcocr.20170202.12
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