International Journal of Clinical Oncology and Cancer Research

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Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products

Received: 09 February 2017    Accepted: 01 March 2017    Published: 20 March 2017
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Abstract

Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-induced cardiotoxicity. Doxorubicin therapy augments oxidative stress and disturbs cytosolic calcium homeostasis, increases intracellular calcium levels from the sarcoplasmic reticulum through activation of the ryanodine receptor and by blighting calcium clearance systems in cardiomyocytes. In this condition the researchers trying to develop cardio-protective strategy to decrease this cardio-toxic effect without decreasing its anticancer effect. Now day's oncologists and pharmacologist work to find out how to decrease the cardiovascular risk and prevent doxorubicin adverse cardiovascular effect. Therefore, the aim of this study was to illustrate the molecular mechanism and possible amelioration of doxorubicin induced-cardiotoxicity via conventional drugs and natural products.

DOI 10.11648/j.ijcocr.20170202.12
Published in International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 2, April 2017)
Page(s) 31-44
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Doxorubicin, Cardiotoxicity, Natural Products

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Author Information
  • Department of Clinical Pharmacology and Therapeutic, Medical Faculty, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq

  • Department of Clinical Pharmacology and Therapeutic, Medical Faculty, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq

  • Bsc Pharmacist, Ministry of Health, Baghdad, Iraq

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    Hayder M. Alkuraishy, Ali I. Al-Gareeb, Hany Akeel Al-hussaniy. (2017). Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products. International Journal of Clinical Oncology and Cancer Research, 2(2), 31-44. https://doi.org/10.11648/j.ijcocr.20170202.12

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    Hayder M. Alkuraishy; Ali I. Al-Gareeb; Hany Akeel Al-hussaniy. Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products. Int. J. Clin. Oncol. Cancer Res. 2017, 2(2), 31-44. doi: 10.11648/j.ijcocr.20170202.12

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    Hayder M. Alkuraishy, Ali I. Al-Gareeb, Hany Akeel Al-hussaniy. Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products. Int J Clin Oncol Cancer Res. 2017;2(2):31-44. doi: 10.11648/j.ijcocr.20170202.12

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  • @article{10.11648/j.ijcocr.20170202.12,
      author = {Hayder M. Alkuraishy and Ali I. Al-Gareeb and Hany Akeel Al-hussaniy},
      title = {Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {2},
      number = {2},
      pages = {31-44},
      doi = {10.11648/j.ijcocr.20170202.12},
      url = {https://doi.org/10.11648/j.ijcocr.20170202.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijcocr.20170202.12},
      abstract = {Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-induced cardiotoxicity. Doxorubicin therapy augments oxidative stress and disturbs cytosolic calcium homeostasis, increases intracellular calcium levels from the sarcoplasmic reticulum through activation of the ryanodine receptor and by blighting calcium clearance systems in cardiomyocytes. In this condition the researchers trying to develop cardio-protective strategy to decrease this cardio-toxic effect without decreasing its anticancer effect. Now day's oncologists and pharmacologist work to find out how to decrease the cardiovascular risk and prevent doxorubicin adverse cardiovascular effect. Therefore, the aim of this study was to illustrate the molecular mechanism and possible amelioration of doxorubicin induced-cardiotoxicity via conventional drugs and natural products.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products
    AU  - Hayder M. Alkuraishy
    AU  - Ali I. Al-Gareeb
    AU  - Hany Akeel Al-hussaniy
    Y1  - 2017/03/20
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ijcocr.20170202.12
    DO  - 10.11648/j.ijcocr.20170202.12
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 31
    EP  - 44
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20170202.12
    AB  - Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-induced cardiotoxicity. Doxorubicin therapy augments oxidative stress and disturbs cytosolic calcium homeostasis, increases intracellular calcium levels from the sarcoplasmic reticulum through activation of the ryanodine receptor and by blighting calcium clearance systems in cardiomyocytes. In this condition the researchers trying to develop cardio-protective strategy to decrease this cardio-toxic effect without decreasing its anticancer effect. Now day's oncologists and pharmacologist work to find out how to decrease the cardiovascular risk and prevent doxorubicin adverse cardiovascular effect. Therefore, the aim of this study was to illustrate the molecular mechanism and possible amelioration of doxorubicin induced-cardiotoxicity via conventional drugs and natural products.
    VL  - 2
    IS  - 2
    ER  - 

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