Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case

Emily Bryer DO; David Henry MD

doi:doi:10.11648/j.ijcocr.20180306.11

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Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case

Emily Bryer DO, David Henry MD

Published in International Journal of Clinical Oncology and Cancer Research (Volume 3, Issue 6)

Received: 22 March 2019 Accepted: 28 April 2019 Published: 27 May 2019

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Abstract

Gestational trophoblastic tumors are a heterogeneous and aggressive group of neoplasms. Choriocarcinoma, an extremely rare subset of gestational trophoblastic tumor, is often metastatic at diagnosis and typically follows a pregnancy that is either ectopic or molar. We present a critical review of choriocarcinomas with an emphasis on choriocarcinomas of ovarian origin which are even more uncommon with an incidence estimated at 1 per 369 million. This manuscript also includes a case of a woman with polycystic ovarian syndrome who required assisted conception to conceive her daughter and then developed a rare extrauterine gestational ovarian choriocarcinoma eighteen months following her antecedent healthy pregnancy with uncomplicated delivery. Many aspects of this presentation are unique, even for such an extraordinary tumor; some of these include the absence of vaginal bleeding, the presence of unilateral pulmonary metastases, and an overwhelmingly positive serum β-hCG with a negative urine β-hCG. While such a discrepancy in urine and serum β-hCG has been reported in gestational trophoblastic disease following molar pregnancies, to our knowledge it has not yet been reported in choriocarcinomas following a normal pregnancy.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 3, Issue 6)
DOI	10.11648/j.ijcocr.20180306.11
Page(s)	72-77
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Gestational Trophoblastic Disease, Ovarian Choriocarcinoma, Beta-Human Chorionic Gonadotropin, Pulmonary Metastases

References

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APA Style

Emily Bryer DO, David Henry MD. (2019). Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case. International Journal of Clinical Oncology and Cancer Research, 3(6), 72-77. https://doi.org/10.11648/j.ijcocr.20180306.11

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ACS Style

Emily Bryer DO; David Henry MD. Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case. Int. J. Clin. Oncol. Cancer Res. 2019, 3(6), 72-77. doi: 10.11648/j.ijcocr.20180306.11

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AMA Style

Emily Bryer DO, David Henry MD. Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case. Int J Clin Oncol Cancer Res. 2019;3(6):72-77. doi: 10.11648/j.ijcocr.20180306.11

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@article{10.11648/j.ijcocr.20180306.11,
  author = {Emily Bryer DO and David Henry MD},
  title = {Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {3},
  number = {6},
  pages = {72-77},
  doi = {10.11648/j.ijcocr.20180306.11},
  url = {https://doi.org/10.11648/j.ijcocr.20180306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20180306.11},
  abstract = {Gestational trophoblastic tumors are a heterogeneous and aggressive group of neoplasms. Choriocarcinoma, an extremely rare subset of gestational trophoblastic tumor, is often metastatic at diagnosis and typically follows a pregnancy that is either ectopic or molar. We present a critical review of choriocarcinomas with an emphasis on choriocarcinomas of ovarian origin which are even more uncommon with an incidence estimated at 1 per 369 million. This manuscript also includes a case of a woman with polycystic ovarian syndrome who required assisted conception to conceive her daughter and then developed a rare extrauterine gestational ovarian choriocarcinoma eighteen months following her antecedent healthy pregnancy with uncomplicated delivery. Many aspects of this presentation are unique, even for such an extraordinary tumor; some of these include the absence of vaginal bleeding, the presence of unilateral pulmonary metastases, and an overwhelmingly positive serum β-hCG with a negative urine β-hCG. While such a discrepancy in urine and serum β-hCG has been reported in gestational trophoblastic disease following molar pregnancies, to our knowledge it has not yet been reported in choriocarcinomas following a normal pregnancy.},
 year = {2019}
}

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TY  - JOUR
T1  - Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case
AU  - Emily Bryer DO
AU  - David Henry MD
Y1  - 2019/05/27
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcocr.20180306.11
DO  - 10.11648/j.ijcocr.20180306.11
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 72
EP  - 77
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20180306.11
AB  - Gestational trophoblastic tumors are a heterogeneous and aggressive group of neoplasms. Choriocarcinoma, an extremely rare subset of gestational trophoblastic tumor, is often metastatic at diagnosis and typically follows a pregnancy that is either ectopic or molar. We present a critical review of choriocarcinomas with an emphasis on choriocarcinomas of ovarian origin which are even more uncommon with an incidence estimated at 1 per 369 million. This manuscript also includes a case of a woman with polycystic ovarian syndrome who required assisted conception to conceive her daughter and then developed a rare extrauterine gestational ovarian choriocarcinoma eighteen months following her antecedent healthy pregnancy with uncomplicated delivery. Many aspects of this presentation are unique, even for such an extraordinary tumor; some of these include the absence of vaginal bleeding, the presence of unilateral pulmonary metastases, and an overwhelmingly positive serum β-hCG with a negative urine β-hCG. While such a discrepancy in urine and serum β-hCG has been reported in gestational trophoblastic disease following molar pregnancies, to our knowledge it has not yet been reported in choriocarcinomas following a normal pregnancy.
VL  - 3
IS  - 6
ER  -

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Author Information

Emily Bryer DO

Department of Internal Medicine, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
David Henry MD

Department of Hematology and Oncology, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA

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APA Style

Emily Bryer DO, David Henry MD. (2019). Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case. International Journal of Clinical Oncology and Cancer Research, 3(6), 72-77. https://doi.org/10.11648/j.ijcocr.20180306.11

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ACS Style

Emily Bryer DO; David Henry MD. Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case. Int. J. Clin. Oncol. Cancer Res. 2019, 3(6), 72-77. doi: 10.11648/j.ijcocr.20180306.11

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AMA Style

Emily Bryer DO, David Henry MD. Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case. Int J Clin Oncol Cancer Res. 2019;3(6):72-77. doi: 10.11648/j.ijcocr.20180306.11

Copy | Download

@article{10.11648/j.ijcocr.20180306.11,
  author = {Emily Bryer DO and David Henry MD},
  title = {Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {3},
  number = {6},
  pages = {72-77},
  doi = {10.11648/j.ijcocr.20180306.11},
  url = {https://doi.org/10.11648/j.ijcocr.20180306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20180306.11},
  abstract = {Gestational trophoblastic tumors are a heterogeneous and aggressive group of neoplasms. Choriocarcinoma, an extremely rare subset of gestational trophoblastic tumor, is often metastatic at diagnosis and typically follows a pregnancy that is either ectopic or molar. We present a critical review of choriocarcinomas with an emphasis on choriocarcinomas of ovarian origin which are even more uncommon with an incidence estimated at 1 per 369 million. This manuscript also includes a case of a woman with polycystic ovarian syndrome who required assisted conception to conceive her daughter and then developed a rare extrauterine gestational ovarian choriocarcinoma eighteen months following her antecedent healthy pregnancy with uncomplicated delivery. Many aspects of this presentation are unique, even for such an extraordinary tumor; some of these include the absence of vaginal bleeding, the presence of unilateral pulmonary metastases, and an overwhelmingly positive serum β-hCG with a negative urine β-hCG. While such a discrepancy in urine and serum β-hCG has been reported in gestational trophoblastic disease following molar pregnancies, to our knowledge it has not yet been reported in choriocarcinomas following a normal pregnancy.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case
AU  - Emily Bryer DO
AU  - David Henry MD
Y1  - 2019/05/27
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcocr.20180306.11
DO  - 10.11648/j.ijcocr.20180306.11
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 72
EP  - 77
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20180306.11
AB  - Gestational trophoblastic tumors are a heterogeneous and aggressive group of neoplasms. Choriocarcinoma, an extremely rare subset of gestational trophoblastic tumor, is often metastatic at diagnosis and typically follows a pregnancy that is either ectopic or molar. We present a critical review of choriocarcinomas with an emphasis on choriocarcinomas of ovarian origin which are even more uncommon with an incidence estimated at 1 per 369 million. This manuscript also includes a case of a woman with polycystic ovarian syndrome who required assisted conception to conceive her daughter and then developed a rare extrauterine gestational ovarian choriocarcinoma eighteen months following her antecedent healthy pregnancy with uncomplicated delivery. Many aspects of this presentation are unique, even for such an extraordinary tumor; some of these include the absence of vaginal bleeding, the presence of unilateral pulmonary metastases, and an overwhelmingly positive serum β-hCG with a negative urine β-hCG. While such a discrepancy in urine and serum β-hCG has been reported in gestational trophoblastic disease following molar pregnancies, to our knowledge it has not yet been reported in choriocarcinomas following a normal pregnancy.
VL  - 3
IS  - 6
ER  -

Copy | Download