Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients

Mwenze Didier; Kyabu Veronique; Mukalay Abdon; Kalenga Prosper; Ilunga Julien

doi:doi:10.11648/j.ijcocr.20190403.11

| Peer-Reviewed

Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients

Mwenze Didier, Kyabu Veronique, Mukalay Abdon, Kalenga Prosper, Ilunga Julien

Published in International Journal of Clinical Oncology and Cancer Research (Volume 4, Issue 3)

Received: 13 August 2019 Accepted: 5 September 2019 Published: 18 September 2019

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The aim of this study is to show the relationship between the index of Papillomavirus infection and the grade of cervical intraepithelial neoplasia as proposed by WHO in Lubumbashi patients. This is a cross-sectional analytical study on cervical biopsies whose histological diagnosis is an intraepithelial neoplasia registered in two Laboratory of Patholoy in Lubumbashi for a period of two years from June 2017 to June 2019. The following results were observed: A total of 41 cases of intraepithelial neoplasia were recorded out of 91 cervical biopsies is 43.2%. Five indices of Human Papillomavirus infection are found in Lubumbashi patients in variable proportions without statistically significant difference; that is the index (5) in 29.27%, the indices (7) and (9) in 21.95% for each index, the index (6) in 17.07% and the index (8) in 9.76%. The three grades of intraepithelial neoplasia proposed by the WHO since 2003 are also found in Lubumbashi patients in varying proportions with no statistically significant difference; 48.78% for grade 3; 36.59% for grade 2 and 14.63% for grade 1. There is no relationship between the HPV infection index and the grade of cervical intraepithelial neoplasia; calculated linear correlation r ^ 2 is equal to 0.00.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 4, Issue 3)
DOI	10.11648/j.ijcocr.20190403.11
Page(s)	29-33
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Papillomavirus Index, Intra-Epithelial Neoplasia, Grade

References

[1]	Sand FL erke, Munk C, Frederiksen K, Junge J, Iftner T, Dehlendorff C, et al. Risk of CIN3 or worse with persistence of 13 individual oncogenic HPV types. Int J Cancer. 2019; 144 (8): 1975–1982.
[2]	Bernichon E, Espenel S, Méry B, Trone J-C, Rehalia-Blanchard A, He YM, et al. Le papillomavirus: implications carcinologiques et mesures préventives. Presse Médicale. 2019.
[3]	Valérie Metang Ngansop. Études des profils viraux et de la protéine p16 dans les néoplasies intra.txt.
[4]	Parra SG, Rodriguez AM, Cherry KD, Schwarz RA, Gowen RM, Guerra LB, et al. Low-cost, high-resolution imaging for detecting cervical precancer in medically-underserved areas of Texas. Gynecol Oncol. 2019.
[5]	Wright TC, Ronnett BM, Kurman RJ. Precancerous lesions of the cervix. Blausteins Pathol Female Genit Tract. 2019; 239–313.
[6]	Debeaudrap P, Sobngwi J, Tebeu P-M, Clifford GM. Residual or recurrent precancerous lesions after treatment of cervical lesions in HIV-infected women: a systematic review and meta-analysis of treatment failure. Clin Infect Dis. 2019.
[7]	Singh C, Kim GN. Cervical Squamous Intraepithelial Lesions: A Pathologist’s Perspective. In: Preventive Oncology for the Gynecologist. Springer; 2019. p. 71–82.
[8]	Boulanger J-C, Sevestre H. ASCUS: état des lieux. Gynécologie Obstétrique Fertil. 2006; 34 (1): 44–48.
[9]	Eble JN, Tavassoli FA, Devilee P. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Iarc; 2003.
[10]	Tavassoli FA. Pathology and genetics of tumours of the breast and female genital organs. World Hhealth Organ Classif Tumours. 2003.
[11]	REYNES M, VEDRENNE C, JAUBERT F, MARTIN E. Cervical neoplasia consensus Paris-Tolbiac 1991: summary and recommandations. Arch Anat Cytol Pathol. 1991; 39 (5–6): 220–222.
[12]	REYNES M, VEDRENNE C, JAUBERT F, MARTIN E. Consensus néoplasies du col utérin Paris-Tolbiac 1991: synthèse de recommandations. Arch Anat Cytol Pathol. 1991; 39 (5–6): 217–219.
[13]	AMRANI M, LALAOUI K, ELMZIBRI M, ROUAS L, BENKIRANE L, LAMAALMI N, et al. TYPAGE PVH ET DÉPISTAGE DU CANCER DU COL DE L’UTÉRUS: RÉSULTATS D’UNE ÉTUDE CRITIQUE MAROCAINE. Maroc Méd. 2002; 24 (3).
[14]	Paolo Dalla Palma MD, Rossi PG, Collina G, Buccoliero AM, Ghiringhello B, Gilioli E, et al. The Reproducibility of CIN Diagnoses Among Different Pathologists Data From Histology Reviews From a Multicenter Randomized Study. Am J Clin Pathol. 2009; 132: 125–132.
[15]	Bergeron C, Ordi J, Schmidt D, Trunk MJ, Ridder R. Improving diagnostic accuracy and inter-observer agreement for CIN2+ through the conjunctive use of p16 immuno-histochemistry on cervical biospies. In: LABORATORY INVESTIGATION. NATURE PUBLISHING GROUP 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA; 2008. p. 198A–198A.
[16]	Tringler B, Gup CJ, Singh M, Groshong S, Shroyer AL, Heinz DE, et al. Evaluation of p16 INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol. 2004; 35 (6): 689–696.
[17]	Van de Putte G, Holm R, Lie AK, Tropé CG, Kristensen GB. Expression of p 27, p 21, and p 16 protein in early squamous cervical cancer and its relation to prognosis. Gynecol Oncol. 2003; 89 (1): 140–147.
[18]	Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T. Immunohistochemical overexpression of p 16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol Int. 1998; 48 (8): 580–585.
[19]	Saito T, Nakajima T, Mogi K. Immunohistochemical analysis of cell cycle-associated proteins p 16, p Rb, p 53, p 27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas. J Oral Pathol Med. 1999; 28 (5): 226–232.
[20]	Belinson J, Qiao YL, Pretorius R, Zhang WH, Elson P, Li L, et al. Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia. Gynecol Oncol. 2001; 83 (2): 439–444.
[21]	Didier M, Phillipe M, Abdon M, Julien I. Cervical smears: morphological and epidemiological study for intra-epithelial neoplasia in Lubumbashi. Int J Clin Oncol Cancer Res. 2018; 3 (4): 55–58.
[22]	Sadeghi SB, Hsieh EW, Gunn SW. Prevalence of cervical intraepithelial neoplasia in sexually active teenagers and young adults: results of data analysis of mass Papanicolaou screening of 796, 337 women in the United States in 1981. Am J Obstet Gynecol. 1984; 148 (6): 726–729.
[23]	Wright JT, Ellerbrock TV, Chiasson MA, Van ND, Sun X-W. Cervical intraepithelial neoplasia in women infected with human immunodeficiency virus: prevalence, risk factors, and validity of Papanicolaou smears. New York Cervical Disease Study. Obstet Gynecol. 1994; 84 (4): 591–597.
[24]	Ellerbrock TV, Chiasson MA, Bush TJ, Sun X-W, Sawo D, Brudney K, et al. Incidence of cervical squamous intraepithelial lesions in HIV-infected women. Jama. 2000; 283 (8): 1031–1037.
[25]	Zhao F-H, Lewkowitz AK, Hu S-Y, Chen F, Li L-Y, Zhang Q-M, et al. Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: A pooled analysis of 17 population-based studies. Int J Cancer. 2012; 131 (12): 2929–2938.
[26]	Verguts J, Bronselaer B, Donders G, Arbyn M, Van Eldere J, Drijkoningen M, et al. Prediction of recurrence after treatment for high-grade cervical intraepithelial neoplasia: the role of human papillomavirus testing and age at conisation. BJOG Int J Obstet Gynaecol. 2006; 113 (11): 1303–1307.
[27]	Chang F, Syrjänen S, Shen Q, Ji H, Syrjänen K. Human papillomavirus (HPV) DNA in esophageal precancer lesions and squamous cell carcinomas from China. Int J Cancer. 1990; 45 (1): 21–25.
[28]	Woo YJ, Yoon HK. In situ hybridization study on human papillomavirus DNA expression in benign and malignant squamous lesions of the esophagus. J Korean Med Sci. 1996; 11 (6): 467–73.
[29]	Toki T, Yajima A. “HPV score”, a scoring system for histological diagnosis of human papillomavirus infection in dysplasia of the uterine cervix. Pathol Int. 1987; 37 (3): 449–455.
[30]	Missaoui N, Hmissa S, Sankaranarayanan R, Deodhar K, Nene B, Budukh A, et al. La surexpression de p16 INK4A est un marqueur utile des lésions du col utérin. In: Annales de biologie clinique. 2010. p. 409–414.
[31]	Tjalma WA, Weyler JJ, Bogers JJ, Pollefliet C, Baay M, Goovaerts GC, et al. The importance of biological factors (bcl-2, bax, p53, PCNA, MI, HPV and angiogenesis) in invasive cervical cancer. Eur J Obstet Gynecol Reprod Biol. 2001; 97 (2): 223–230.

Cite This Article

Plain Text BibTeX RIS

APA Style

Mwenze Didier, Kyabu Veronique, Mukalay Abdon, Kalenga Prosper, Ilunga Julien. (2019). Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients. International Journal of Clinical Oncology and Cancer Research, 4(3), 29-33. https://doi.org/10.11648/j.ijcocr.20190403.11

Copy | Download

ACS Style

Mwenze Didier; Kyabu Veronique; Mukalay Abdon; Kalenga Prosper; Ilunga Julien. Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients. Int. J. Clin. Oncol. Cancer Res. 2019, 4(3), 29-33. doi: 10.11648/j.ijcocr.20190403.11

Copy | Download

AMA Style

Mwenze Didier, Kyabu Veronique, Mukalay Abdon, Kalenga Prosper, Ilunga Julien. Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients. Int J Clin Oncol Cancer Res. 2019;4(3):29-33. doi: 10.11648/j.ijcocr.20190403.11

Copy | Download

@article{10.11648/j.ijcocr.20190403.11,
  author = {Mwenze Didier and Kyabu Veronique and Mukalay Abdon and Kalenga Prosper and Ilunga Julien},
  title = {Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {4},
  number = {3},
  pages = {29-33},
  doi = {10.11648/j.ijcocr.20190403.11},
  url = {https://doi.org/10.11648/j.ijcocr.20190403.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20190403.11},
  abstract = {The aim of this study is to show the relationship between the index of Papillomavirus infection and the grade of cervical intraepithelial neoplasia as proposed by WHO in Lubumbashi patients. This is a cross-sectional analytical study on cervical biopsies whose histological diagnosis is an intraepithelial neoplasia registered in two Laboratory of Patholoy in Lubumbashi for a period of two years from June 2017 to June 2019. The following results were observed: A total of 41 cases of intraepithelial neoplasia were recorded out of 91 cervical biopsies is 43.2%. Five indices of Human Papillomavirus infection are found in Lubumbashi patients in variable proportions without statistically significant difference; that is the index (5) in 29.27%, the indices (7) and (9) in 21.95% for each index, the index (6) in 17.07% and the index (8) in 9.76%. The three grades of intraepithelial neoplasia proposed by the WHO since 2003 are also found in Lubumbashi patients in varying proportions with no statistically significant difference; 48.78% for grade 3; 36.59% for grade 2 and 14.63% for grade 1. There is no relationship between the HPV infection index and the grade of cervical intraepithelial neoplasia; calculated linear correlation r ^ 2 is equal to 0.00.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients
AU  - Mwenze Didier
AU  - Kyabu Veronique
AU  - Mukalay Abdon
AU  - Kalenga Prosper
AU  - Ilunga Julien
Y1  - 2019/09/18
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcocr.20190403.11
DO  - 10.11648/j.ijcocr.20190403.11
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 29
EP  - 33
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20190403.11
AB  - The aim of this study is to show the relationship between the index of Papillomavirus infection and the grade of cervical intraepithelial neoplasia as proposed by WHO in Lubumbashi patients. This is a cross-sectional analytical study on cervical biopsies whose histological diagnosis is an intraepithelial neoplasia registered in two Laboratory of Patholoy in Lubumbashi for a period of two years from June 2017 to June 2019. The following results were observed: A total of 41 cases of intraepithelial neoplasia were recorded out of 91 cervical biopsies is 43.2%. Five indices of Human Papillomavirus infection are found in Lubumbashi patients in variable proportions without statistically significant difference; that is the index (5) in 29.27%, the indices (7) and (9) in 21.95% for each index, the index (6) in 17.07% and the index (8) in 9.76%. The three grades of intraepithelial neoplasia proposed by the WHO since 2003 are also found in Lubumbashi patients in varying proportions with no statistically significant difference; 48.78% for grade 3; 36.59% for grade 2 and 14.63% for grade 1. There is no relationship between the HPV infection index and the grade of cervical intraepithelial neoplasia; calculated linear correlation r ^ 2 is equal to 0.00.
VL  - 4
IS  - 3
ER  -

Copy | Download

Author Information

Mwenze Didier

Department of Pathology, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Kyabu Veronique

Department of Pathology, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Mukalay Abdon

Department of Public Health, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Kalenga Prosper

Department of Gynecology Obstetrics, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Ilunga Julien

Department of Pathology, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Mwenze Didier, Kyabu Veronique, Mukalay Abdon, Kalenga Prosper, Ilunga Julien. (2019). Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients. International Journal of Clinical Oncology and Cancer Research, 4(3), 29-33. https://doi.org/10.11648/j.ijcocr.20190403.11

Copy | Download

ACS Style

Mwenze Didier; Kyabu Veronique; Mukalay Abdon; Kalenga Prosper; Ilunga Julien. Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients. Int. J. Clin. Oncol. Cancer Res. 2019, 4(3), 29-33. doi: 10.11648/j.ijcocr.20190403.11

Copy | Download

AMA Style

Mwenze Didier, Kyabu Veronique, Mukalay Abdon, Kalenga Prosper, Ilunga Julien. Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients. Int J Clin Oncol Cancer Res. 2019;4(3):29-33. doi: 10.11648/j.ijcocr.20190403.11

Copy | Download

@article{10.11648/j.ijcocr.20190403.11,
  author = {Mwenze Didier and Kyabu Veronique and Mukalay Abdon and Kalenga Prosper and Ilunga Julien},
  title = {Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {4},
  number = {3},
  pages = {29-33},
  doi = {10.11648/j.ijcocr.20190403.11},
  url = {https://doi.org/10.11648/j.ijcocr.20190403.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20190403.11},
  abstract = {The aim of this study is to show the relationship between the index of Papillomavirus infection and the grade of cervical intraepithelial neoplasia as proposed by WHO in Lubumbashi patients. This is a cross-sectional analytical study on cervical biopsies whose histological diagnosis is an intraepithelial neoplasia registered in two Laboratory of Patholoy in Lubumbashi for a period of two years from June 2017 to June 2019. The following results were observed: A total of 41 cases of intraepithelial neoplasia were recorded out of 91 cervical biopsies is 43.2%. Five indices of Human Papillomavirus infection are found in Lubumbashi patients in variable proportions without statistically significant difference; that is the index (5) in 29.27%, the indices (7) and (9) in 21.95% for each index, the index (6) in 17.07% and the index (8) in 9.76%. The three grades of intraepithelial neoplasia proposed by the WHO since 2003 are also found in Lubumbashi patients in varying proportions with no statistically significant difference; 48.78% for grade 3; 36.59% for grade 2 and 14.63% for grade 1. There is no relationship between the HPV infection index and the grade of cervical intraepithelial neoplasia; calculated linear correlation r ^ 2 is equal to 0.00.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Cervical Intra-Epithelial Neoplasia: Index of Papillomavirus Infection and Histopathological Grade in Lubumbashi Patients
AU  - Mwenze Didier
AU  - Kyabu Veronique
AU  - Mukalay Abdon
AU  - Kalenga Prosper
AU  - Ilunga Julien
Y1  - 2019/09/18
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcocr.20190403.11
DO  - 10.11648/j.ijcocr.20190403.11
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 29
EP  - 33
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20190403.11
AB  - The aim of this study is to show the relationship between the index of Papillomavirus infection and the grade of cervical intraepithelial neoplasia as proposed by WHO in Lubumbashi patients. This is a cross-sectional analytical study on cervical biopsies whose histological diagnosis is an intraepithelial neoplasia registered in two Laboratory of Patholoy in Lubumbashi for a period of two years from June 2017 to June 2019. The following results were observed: A total of 41 cases of intraepithelial neoplasia were recorded out of 91 cervical biopsies is 43.2%. Five indices of Human Papillomavirus infection are found in Lubumbashi patients in variable proportions without statistically significant difference; that is the index (5) in 29.27%, the indices (7) and (9) in 21.95% for each index, the index (6) in 17.07% and the index (8) in 9.76%. The three grades of intraepithelial neoplasia proposed by the WHO since 2003 are also found in Lubumbashi patients in varying proportions with no statistically significant difference; 48.78% for grade 3; 36.59% for grade 2 and 14.63% for grade 1. There is no relationship between the HPV infection index and the grade of cervical intraepithelial neoplasia; calculated linear correlation r ^ 2 is equal to 0.00.
VL  - 4
IS  - 3
ER  -

Copy | Download