The significant cancer pain syndrome of malignant psoas syndrome (MPS), was first reported as a neurooncologic occurrence in 1990. The Syndrome is characterised by malignant infiltration of a psoas muscle, either directly or by involvement with haematogenously disseminated metastatic cancer. Direct involvement has been from primary tumours of the psoas muscle, or by extension from malignant paraaortic lymphadenopathy. Treatment is difficult, complex analgesia is essential, and benefits have been achieved from chemotherapy, radiotherapy and in select cases, surgery. Here, the case of a 60 year old female who presented with three months of moderate dyspnoea, low back and left inguinal region pain/numbness and lassitude, is reported. Chest radiograph and CT showed a large anterior mediastinal mass. FDG PET/CT revealed the mass to be intensely avid, with heterogeneous central areas of photopaenia. Avid lymphadenopathy was also present in two mediastinal nodal stations. Subdiaphragmatically, there was a metabolically FDG avid soft tissue mass in the superior part of the left psoas muscle, presumably accounting for her pain. There was no FDG avidity elsewhere. Core biopsy of the psoas mass revealed adenocarcinoma of probable lung origin. The patient responded symptomatically to intermediate dose radiation therapy. The pathophysiology of MPS is discussed and the range of cancer types associated with the Syndrome is updated.
| Published in | International Journal of Clinical Oncology and Cancer Research (Volume 6, Issue 3) |
| DOI | 10.11648/j.ijcocr.20210603.17 |
| Page(s) | 141-144 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Malignant Psoas Syndrome, MPS, PET/CT, Non Small-cell Lung Cancer
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APA Style
Michael Jerome McKay, Aaron Chindewere, Laura Wise, Fraser Brown, Kim Louise Taubman, et al. (2021). Malignant Psoas Syndrome Demonstrated by PET/CT in the Context of Metastatic Non Small Cell Lung Cancer. International Journal of Clinical Oncology and Cancer Research, 6(3), 141-144. https://doi.org/10.11648/j.ijcocr.20210603.17
ACS Style
Michael Jerome McKay; Aaron Chindewere; Laura Wise; Fraser Brown; Kim Louise Taubman, et al. Malignant Psoas Syndrome Demonstrated by PET/CT in the Context of Metastatic Non Small Cell Lung Cancer. Int. J. Clin. Oncol. Cancer Res. 2021, 6(3), 141-144. doi: 10.11648/j.ijcocr.20210603.17
AMA Style
Michael Jerome McKay, Aaron Chindewere, Laura Wise, Fraser Brown, Kim Louise Taubman, et al. Malignant Psoas Syndrome Demonstrated by PET/CT in the Context of Metastatic Non Small Cell Lung Cancer. Int J Clin Oncol Cancer Res. 2021;6(3):141-144. doi: 10.11648/j.ijcocr.20210603.17
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Download@article{10.11648/j.ijcocr.20210603.17,
author = {Michael Jerome McKay and Aaron Chindewere and Laura Wise and Fraser Brown and Kim Louise Taubman and Timothy Michael McKay},
title = {Malignant Psoas Syndrome Demonstrated by PET/CT in the Context of Metastatic Non Small Cell Lung Cancer},
journal = {International Journal of Clinical Oncology and Cancer Research},
volume = {6},
number = {3},
pages = {141-144},
doi = {10.11648/j.ijcocr.20210603.17},
url = {https://doi.org/10.11648/j.ijcocr.20210603.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20210603.17},
abstract = {The significant cancer pain syndrome of malignant psoas syndrome (MPS), was first reported as a neurooncologic occurrence in 1990. The Syndrome is characterised by malignant infiltration of a psoas muscle, either directly or by involvement with haematogenously disseminated metastatic cancer. Direct involvement has been from primary tumours of the psoas muscle, or by extension from malignant paraaortic lymphadenopathy. Treatment is difficult, complex analgesia is essential, and benefits have been achieved from chemotherapy, radiotherapy and in select cases, surgery. Here, the case of a 60 year old female who presented with three months of moderate dyspnoea, low back and left inguinal region pain/numbness and lassitude, is reported. Chest radiograph and CT showed a large anterior mediastinal mass. FDG PET/CT revealed the mass to be intensely avid, with heterogeneous central areas of photopaenia. Avid lymphadenopathy was also present in two mediastinal nodal stations. Subdiaphragmatically, there was a metabolically FDG avid soft tissue mass in the superior part of the left psoas muscle, presumably accounting for her pain. There was no FDG avidity elsewhere. Core biopsy of the psoas mass revealed adenocarcinoma of probable lung origin. The patient responded symptomatically to intermediate dose radiation therapy. The pathophysiology of MPS is discussed and the range of cancer types associated with the Syndrome is updated.},
year = {2021}
}
TY - JOUR T1 - Malignant Psoas Syndrome Demonstrated by PET/CT in the Context of Metastatic Non Small Cell Lung Cancer AU - Michael Jerome McKay AU - Aaron Chindewere AU - Laura Wise AU - Fraser Brown AU - Kim Louise Taubman AU - Timothy Michael McKay Y1 - 2021/08/18 PY - 2021 N1 - https://doi.org/10.11648/j.ijcocr.20210603.17 DO - 10.11648/j.ijcocr.20210603.17 T2 - International Journal of Clinical Oncology and Cancer Research JF - International Journal of Clinical Oncology and Cancer Research JO - International Journal of Clinical Oncology and Cancer Research SP - 141 EP - 144 PB - Science Publishing Group SN - 2578-9511 UR - https://doi.org/10.11648/j.ijcocr.20210603.17 AB - The significant cancer pain syndrome of malignant psoas syndrome (MPS), was first reported as a neurooncologic occurrence in 1990. The Syndrome is characterised by malignant infiltration of a psoas muscle, either directly or by involvement with haematogenously disseminated metastatic cancer. Direct involvement has been from primary tumours of the psoas muscle, or by extension from malignant paraaortic lymphadenopathy. Treatment is difficult, complex analgesia is essential, and benefits have been achieved from chemotherapy, radiotherapy and in select cases, surgery. Here, the case of a 60 year old female who presented with three months of moderate dyspnoea, low back and left inguinal region pain/numbness and lassitude, is reported. Chest radiograph and CT showed a large anterior mediastinal mass. FDG PET/CT revealed the mass to be intensely avid, with heterogeneous central areas of photopaenia. Avid lymphadenopathy was also present in two mediastinal nodal stations. Subdiaphragmatically, there was a metabolically FDG avid soft tissue mass in the superior part of the left psoas muscle, presumably accounting for her pain. There was no FDG avidity elsewhere. Core biopsy of the psoas mass revealed adenocarcinoma of probable lung origin. The patient responded symptomatically to intermediate dose radiation therapy. The pathophysiology of MPS is discussed and the range of cancer types associated with the Syndrome is updated. VL - 6 IS - 3 ER -
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