Pediatric and Adolescent Medicine

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Review and Update on Malformations of Cortical Development and Neuronal Migration Disorders

Received: 30 October 2016    Accepted: 13 December 2016    Published: 12 January 2017
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Abstract

Cortical development malformations (CDM) and specifically disorders of neuronal migration are a group of congenital malformations of the central nervous system (CNS) that are linked to some of the neurodevelopment disorders frequently described in children, such as mental retardation, autism, schizophrenia and epilepsy, among others. CDM are classified into three groups: Group I for alterations in proliferation and/or glial and neuronal apoptosis; Group II for neuronal migration disorders; and group III for secondary malformations due to postmigrational alterations of development. Neocortical neurons migration occurs preferentially from the fifth week of gestation until the twenty-second gestational week. Neuronal migration disorders are classified into four groups: II. A lissencephaly, II. B periventricular heterotopia, II. C subcortical heterotopia and II. D sublobar dysplasia and "cobblestone" malformations.

DOI 10.11648/j.pam.20160101.13
Published in Pediatric and Adolescent Medicine (Volume 1, Issue 1, December 2016)
Page(s) 16-19
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

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Keywords

Cortical Development Malformations, Lissencephaly, Schizencephaly, Polymicrogyria

References
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[10] Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK, et al. Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Neuron. 2011; 69 (4): 763–79.
[11] Meyer G. Genetic control of neuronal migrations in human cortical development. Adv Anat Embryol Cell Biol 2007; 189: 1–111.
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Author Information
  • Department of Pediatrics, Marqués de Valdecilla University Hospital, Cantabria, Spain

  • Ophthalmology Department, Sierrallana Hospital, Barrio de Ganzo, Cantabria, Spain

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    Andrea Fernández-Menéndez, Alfonso Casado. (2017). Review and Update on Malformations of Cortical Development and Neuronal Migration Disorders. Pediatric and Adolescent Medicine, 1(1), 16-19. https://doi.org/10.11648/j.pam.20160101.13

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    ACS Style

    Andrea Fernández-Menéndez; Alfonso Casado. Review and Update on Malformations of Cortical Development and Neuronal Migration Disorders. Pediatr. Adolesc. Med. 2017, 1(1), 16-19. doi: 10.11648/j.pam.20160101.13

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    AMA Style

    Andrea Fernández-Menéndez, Alfonso Casado. Review and Update on Malformations of Cortical Development and Neuronal Migration Disorders. Pediatr Adolesc Med. 2017;1(1):16-19. doi: 10.11648/j.pam.20160101.13

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  • @article{10.11648/j.pam.20160101.13,
      author = {Andrea Fernández-Menéndez and Alfonso Casado},
      title = {Review and Update on Malformations of Cortical Development and Neuronal Migration Disorders},
      journal = {Pediatric and Adolescent Medicine},
      volume = {1},
      number = {1},
      pages = {16-19},
      doi = {10.11648/j.pam.20160101.13},
      url = {https://doi.org/10.11648/j.pam.20160101.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.pam.20160101.13},
      abstract = {Cortical development malformations (CDM) and specifically disorders of neuronal migration are a group of congenital malformations of the central nervous system (CNS) that are linked to some of the neurodevelopment disorders frequently described in children, such as mental retardation, autism, schizophrenia and epilepsy, among others. CDM are classified into three groups: Group I for alterations in proliferation and/or glial and neuronal apoptosis; Group II for neuronal migration disorders; and group III for secondary malformations due to postmigrational alterations of development. Neocortical neurons migration occurs preferentially from the fifth week of gestation until the twenty-second gestational week. Neuronal migration disorders are classified into four groups: II. A lissencephaly, II. B periventricular heterotopia, II. C subcortical heterotopia and II. D sublobar dysplasia and "cobblestone" malformations.},
     year = {2017}
    }
    

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    AB  - Cortical development malformations (CDM) and specifically disorders of neuronal migration are a group of congenital malformations of the central nervous system (CNS) that are linked to some of the neurodevelopment disorders frequently described in children, such as mental retardation, autism, schizophrenia and epilepsy, among others. CDM are classified into three groups: Group I for alterations in proliferation and/or glial and neuronal apoptosis; Group II for neuronal migration disorders; and group III for secondary malformations due to postmigrational alterations of development. Neocortical neurons migration occurs preferentially from the fifth week of gestation until the twenty-second gestational week. Neuronal migration disorders are classified into four groups: II. A lissencephaly, II. B periventricular heterotopia, II. C subcortical heterotopia and II. D sublobar dysplasia and "cobblestone" malformations.
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