Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer

Kang Jun-Il; Paek Mi-Yong

doi:doi:10.11648/j.pam.20170203.13

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Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer

Kang Jun-Il, Paek Mi-Yong

Published in Pediatric and Adolescent Medicine (Volume 2, Issue 3)

Received: 14 June 2017 Accepted: 7 July 2017 Published: 7 August 2017

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Abstract

Polycystic ovary syndrome (PCOS) is a common disorder of women in reproductive age characterized by clinical and biochemical disorders, and it´s main symptoms might appear from adolescnce. PCOS (polycystic ovary syndrome) is characterized by menstrual disorders (amenorrhea or oligomenorrhea), anovulation, hyperandrogenism and polycystic change of ovaries. Insulin-resistant hyperinsulinism is an important extrinsic factor in the steroidogenic dysregulation of PCOS and lowers the treatment of ovulation. I investigate the relation between hyperinsulinemia and PCOS and the effect of metformin, insulin sensitizer in treatment of PCOS by case-control study of 30 patients with clomiphene citrate-resistant PCOS and 30 women with regular menstrual cycles. Patients with PCOS had hyperinsulinemia compared with control group significantly. The ovulation rate of laparoscopic ovarian drilling plus metformin therapy was 95.5% (21/22).

Published in	Pediatric and Adolescent Medicine (Volume 2, Issue 3)
DOI	10.11648/j.pam.20170203.13
Page(s)	58-61
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Polycystic Ovary Syndrome, Hyperinsulinemia, Metformin

References

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[2]	Carmina E, Rosato F et al: Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. J Clin Endocrinol Metab, 91, 2-6, 2006.
[3]	Book CB, Dunaif A. et al: J Clin Endocrinol Metab, 84, 3110, 1999.
[4]	Nestler, JE, Powers, LP, Matt, DW, et al: A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J Clin Endocrinol Metab, 72, 83-9, 1991.
[5]	Yuan Wang et al: Local effect of bisphenol A on the estradiol synthesis of ovarian granulosa cells from PCOS. Gynecological Endocrinology, 33, 21-25, 2017.
[6]	Dorte Glintborg & Marianne Andersen: Thiazolinedione treatment in PCOS – an update. Gynecological Endocrinology, 26, 791-803, 2010.
[7]	A. Köşüş et al: Clitoral and labial sizes in women wıth PCOS. Journal of Obstetrics and Gynaecology, 36, 97-101, 2016.
[8]	Julio Vázquez Rojo et al: Infertile couples’ assessment of infertility treatment. Acta Obstetricia et Gynecologica Scandinavica, 80, 158, 2001.
[9]	Carina Santos et al: Effects of life events on infertility diagnosis: comparison with presumably fertile men and women. Journal of Reproductive and Infant Psychology, 35, 1-13, 2017.
[10]	Robab Latifnejad Roudsari et al: Iranian and English women's use of religion and spirituality as resources for coping with infertility. Human Fertility, 17, 114-123, 2014.
[11]	Ewa Barcz et al: A relationship between increased peritoneal leptin levels and infertility in endometriosis. Gynecological Endocrinology, 24, 526-530, 2008.
[12]	J. Balasch et al: Infertility factors and pregnancy outcome in women above age 35. Gynecological Endocrinology, 6, 31-35, 1992.
[13]	Floriana Morgillo et al: Metformin in lung cancer: rationale for a combination therapy. Expert Opinion on Investigational Drugs, 22, 1401-1409, 2013.
[14]	Stephen I. Rifkin et al: Prolonged Hemodialysis for Severe Metformin Intoxication. Renal Failure, 33, 459-461, 2011.
[15]	Ricardo Ladeiras-Lopes et al: Novel therapeutic targets of metformin: metabolic syndrome and cardiovascular disease. Expert Opinion on Therapeutic Targets, 19, 869-877, 2015.
[16]	Gregory A. Nichols et al: Initial nonadherence, primary failure and therapeutic success of metformin monotherapy in clinical practice. Current Medical Research and Opinion, 26, 2127-2135, 2010.

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APA Style

Kang Jun-Il, Paek Mi-Yong. (2017). Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer. Pediatric and Adolescent Medicine, 2(3), 58-61. https://doi.org/10.11648/j.pam.20170203.13

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ACS Style

Kang Jun-Il; Paek Mi-Yong. Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer. Pediatr. Adolesc. Med. 2017, 2(3), 58-61. doi: 10.11648/j.pam.20170203.13

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AMA Style

Kang Jun-Il, Paek Mi-Yong. Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer. Pediatr Adolesc Med. 2017;2(3):58-61. doi: 10.11648/j.pam.20170203.13

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@article{10.11648/j.pam.20170203.13,
  author = {Kang Jun-Il and Paek Mi-Yong},
  title = {Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer},
  journal = {Pediatric and Adolescent Medicine},
  volume = {2},
  number = {3},
  pages = {58-61},
  doi = {10.11648/j.pam.20170203.13},
  url = {https://doi.org/10.11648/j.pam.20170203.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pam.20170203.13},
  abstract = {Polycystic ovary syndrome (PCOS) is a common disorder of women in reproductive age characterized by clinical and biochemical disorders, and it´s main symptoms might appear from adolescnce. PCOS (polycystic ovary syndrome) is characterized by menstrual disorders (amenorrhea or oligomenorrhea), anovulation, hyperandrogenism and polycystic change of ovaries. Insulin-resistant hyperinsulinism is an important extrinsic factor in the steroidogenic dysregulation of PCOS and lowers the treatment of ovulation. I investigate the relation between hyperinsulinemia and PCOS and the effect of metformin, insulin sensitizer in treatment of PCOS by case-control study of 30 patients with clomiphene citrate-resistant PCOS and 30 women with regular menstrual cycles. Patients with PCOS had hyperinsulinemia compared with control group significantly. The ovulation rate of laparoscopic ovarian drilling plus metformin therapy was 95.5% (21/22).},
 year = {2017}
}

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TY  - JOUR
T1  - Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer
AU  - Kang Jun-Il
AU  - Paek Mi-Yong
Y1  - 2017/08/07
PY  - 2017
N1  - https://doi.org/10.11648/j.pam.20170203.13
DO  - 10.11648/j.pam.20170203.13
T2  - Pediatric and Adolescent Medicine
JF  - Pediatric and Adolescent Medicine
JO  - Pediatric and Adolescent Medicine
SP  - 58
EP  - 61
PB  - Science Publishing Group
UR  - https://doi.org/10.11648/j.pam.20170203.13
AB  - Polycystic ovary syndrome (PCOS) is a common disorder of women in reproductive age characterized by clinical and biochemical disorders, and it´s main symptoms might appear from adolescnce. PCOS (polycystic ovary syndrome) is characterized by menstrual disorders (amenorrhea or oligomenorrhea), anovulation, hyperandrogenism and polycystic change of ovaries. Insulin-resistant hyperinsulinism is an important extrinsic factor in the steroidogenic dysregulation of PCOS and lowers the treatment of ovulation. I investigate the relation between hyperinsulinemia and PCOS and the effect of metformin, insulin sensitizer in treatment of PCOS by case-control study of 30 patients with clomiphene citrate-resistant PCOS and 30 women with regular menstrual cycles. Patients with PCOS had hyperinsulinemia compared with control group significantly. The ovulation rate of laparoscopic ovarian drilling plus metformin therapy was 95.5% (21/22).
VL  - 2
IS  - 3
ER  -

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Author Information

Kang Jun-Il

Department of Obstetrics and Gynecology, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People’s Republic of Korea
Paek Mi-Yong

Department of Obstetrics and Gynecology, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People’s Republic of Korea

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APA Style

Kang Jun-Il, Paek Mi-Yong. (2017). Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer. Pediatric and Adolescent Medicine, 2(3), 58-61. https://doi.org/10.11648/j.pam.20170203.13

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ACS Style

Kang Jun-Il; Paek Mi-Yong. Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer. Pediatr. Adolesc. Med. 2017, 2(3), 58-61. doi: 10.11648/j.pam.20170203.13

Copy | Download

AMA Style

Kang Jun-Il, Paek Mi-Yong. Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer. Pediatr Adolesc Med. 2017;2(3):58-61. doi: 10.11648/j.pam.20170203.13

Copy | Download

@article{10.11648/j.pam.20170203.13,
  author = {Kang Jun-Il and Paek Mi-Yong},
  title = {Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer},
  journal = {Pediatric and Adolescent Medicine},
  volume = {2},
  number = {3},
  pages = {58-61},
  doi = {10.11648/j.pam.20170203.13},
  url = {https://doi.org/10.11648/j.pam.20170203.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pam.20170203.13},
  abstract = {Polycystic ovary syndrome (PCOS) is a common disorder of women in reproductive age characterized by clinical and biochemical disorders, and it´s main symptoms might appear from adolescnce. PCOS (polycystic ovary syndrome) is characterized by menstrual disorders (amenorrhea or oligomenorrhea), anovulation, hyperandrogenism and polycystic change of ovaries. Insulin-resistant hyperinsulinism is an important extrinsic factor in the steroidogenic dysregulation of PCOS and lowers the treatment of ovulation. I investigate the relation between hyperinsulinemia and PCOS and the effect of metformin, insulin sensitizer in treatment of PCOS by case-control study of 30 patients with clomiphene citrate-resistant PCOS and 30 women with regular menstrual cycles. Patients with PCOS had hyperinsulinemia compared with control group significantly. The ovulation rate of laparoscopic ovarian drilling plus metformin therapy was 95.5% (21/22).},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Treatment of Polycystic Ovary Syndrome with Insulin Sensitizer
AU  - Kang Jun-Il
AU  - Paek Mi-Yong
Y1  - 2017/08/07
PY  - 2017
N1  - https://doi.org/10.11648/j.pam.20170203.13
DO  - 10.11648/j.pam.20170203.13
T2  - Pediatric and Adolescent Medicine
JF  - Pediatric and Adolescent Medicine
JO  - Pediatric and Adolescent Medicine
SP  - 58
EP  - 61
PB  - Science Publishing Group
UR  - https://doi.org/10.11648/j.pam.20170203.13
AB  - Polycystic ovary syndrome (PCOS) is a common disorder of women in reproductive age characterized by clinical and biochemical disorders, and it´s main symptoms might appear from adolescnce. PCOS (polycystic ovary syndrome) is characterized by menstrual disorders (amenorrhea or oligomenorrhea), anovulation, hyperandrogenism and polycystic change of ovaries. Insulin-resistant hyperinsulinism is an important extrinsic factor in the steroidogenic dysregulation of PCOS and lowers the treatment of ovulation. I investigate the relation between hyperinsulinemia and PCOS and the effect of metformin, insulin sensitizer in treatment of PCOS by case-control study of 30 patients with clomiphene citrate-resistant PCOS and 30 women with regular menstrual cycles. Patients with PCOS had hyperinsulinemia compared with control group significantly. The ovulation rate of laparoscopic ovarian drilling plus metformin therapy was 95.5% (21/22).
VL  - 2
IS  - 3
ER  -

Copy | Download