Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus
International Journal of Diabetes and Endocrinology
Volume 1, Issue 1, December 2016, Pages: 8-12
Received: Nov. 4, 2016;
Accepted: Dec. 2, 2016;
Published: Dec. 27, 2016
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Hayder M. Al-kuraishy, Department of Pharmacology, Toxicology and Medicine College of Medicine, Almustansiriya University, Baghdad, Iraq
Ali I. Al-Gareeb, Department of Pharmacology, Toxicology and Medicine College of Medicine, Almustansiriya University, Baghdad, Iraq
Salah A. Al-Windy, Department of Biology and Biochemistry, College of Sciences, Baghdad University, Baghdad, Iraq
Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.
Hayder M. Al-kuraishy,
Ali I. Al-Gareeb,
Salah A. Al-Windy,
Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus, International Journal of Diabetes and Endocrinology.
Vol. 1, No. 1,
2016, pp. 8-12.
Thomas Reinehr. Type 2 diabetes mellitus in children and adolescents. World J Diabetes. 2013 15; 4 (6): 270–281.
Ayman A. Al Hayek, Yousef S. Khader, SaharJafal, NahlaKhawaja, Asirvatham A. Robert, et al. Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. J Family Community Med. 2013; 20(3): 179–186.
Ranabir Salam, Achouba Singh Kshetrimayum, and ReetuKeisam. Testosterone and metabolic syndrome: The link. Indian J EndocrinolMetab. 2012; 16 (Suppl1): S12–S19.
Gregory S. Sayuk, Britt M. Gott, Billy D. Nix, Patrick J. Lustman. Improvement in Sexual Functioning in Patients With Type 2 Diabetes and Depression Treated With Bupropion. Diabetes Care 2011; 34 (2): 332-334.
MarziehFarimaniSanoee, NosratNeghab, SoghraRabiee, IrajAmiri. Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome. Iran J Med Sci. 2011; 36 (2): 90–95.
Alkuraishy, Hayder M.; Al-Gareeb, Ali I. New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study. Emergency Medicine International.11/23/2015, p1-8. 8p.
Manuel Castro Cabezas, Jeroen P. H. van Wijk, Jan Willem F. Elte, BoudewijnKlop. Effects of Metformin on the Regulation of Free Fatty Acids in Insulin Resistance: A Double-Blind, Placebo-Controlled Study. Journal of Nutrition and Metabolism 2012; 394623, 7.
Johannes Klein, SörenWestphal, Daniel Kraus, Britta Meier, Nina Perwitz, VolkerOtt, et al. Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes. Journal of endocrinology. 2004; 183 (3): 307.
Saul Genuth. Should Sulfonylureas Remain an Acceptable First-Line Add-on to Metformin Therapy in Patients With Type 2 Diabetes? No, It’s Time to Move On!Diabetes Care 2015 Jan; 38 (1): 170-175.
Elena Volpi, MD, Steven A. Lieberman, Dennis M. Ferrer, Charles R. Gilkison, et al. The Relationships Between Testosterone, Body Composition, and Insulin Resistance. Diabetes Care 2005; 28 (2): 429-432.
Michael L Ganz, Neil Wintfeld, Qian Li, Veronica Alas, Jakob Langer, Mette Hammer. The association of body mass index with the risk of type 2 diabetes: a case–control study nested in an electronic health records system in the United States. Diabetology& Metabolic Syndrome 20146: 50.
Naoto Fukuyama, Kazuhiro Homma, NoriakiWakana, Kaori Kudo, AsakoSuyama, HikariOhazama, Chizuko Tsuji, et al. Validation of the Friedewald Equation for Evaluation of Plasma LDL-Cholesterol. JClinBiochemNutr. 2008; 43 (1): 1–5.
NirmaliMattack, Runi Devi, TridipKutum, DibyaratnaPatgiri. The Evaluation of Serum Levels of Testosterone in Type 2 Diabetic Men and Its Relation with Lipid Profile. J ClinDiagn Res. 2015; 9 (1): BC04–BC07.
Zhao J, Zhai L, Liu Z, Wu S, Xu L. Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue. Oxid Med Cell Longev 2014; 2014: 190945.
Yen-Jui Chang, Cai-Yun Jian, Chih-Yung Lin, Ya-Wen Hsu, Paulus S. Wang. Effects of Type 2 Diabetes on Testosterone Production in Male Rats. Biology of Reproduction.2008, 78; Suppl 1, 216.
Maggio M, Basaria S. Welcoming low testosterone as a cardiovascular risk factor. InternationalJournal of Impotence Research. 2009; 21: 261–64.
Jesse Oliver Tweed, Stanley H. Hsia, KabirullahLutfy, Theodore C. Friedman. The endocrine effects of nicotine and cigarette smoke. Trends EndocrinolMetab. 2012; 23 (7): 334–342.
OzataM, OktenliC, Bingol. The effects of metformin and diet on plasma testosterone and leptin levels in obese men. Obes Res 2001; 9 (11): 662-7.
Wong L, Chen HM, Lai SQ, Yang HZ, Kuang J, Pei JH. Effects of sulfonylurea as initial treatment on testosterone of middle ged men with type 2 diabetes: A 16-week, pilot study. J Diabetes Investig2015; 6 (4):454-9.
Bledar Daka, Robert D. Langer, Charlotte A. Larsson, Thord Rosén, Per Anders Jansson, et al. Low concentrations of serum testosterone predict acute myocardial infarction in men with type 2 diabetes mellitus. BMC Endocrine Disorders 201515: 35.