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Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus
International Journal of Diabetes and Endocrinology
Volume 1, Issue 1, December 2016, Pages: 8-12
Received: Nov. 4, 2016; Accepted: Dec. 2, 2016; Published: Dec. 27, 2016
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Hayder M. Al-kuraishy, Department of Pharmacology, Toxicology and Medicine College of Medicine, Almustansiriya University, Baghdad, Iraq
Ali I. Al-Gareeb, Department of Pharmacology, Toxicology and Medicine College of Medicine, Almustansiriya University, Baghdad, Iraq
Salah A. Al-Windy, Department of Biology and Biochemistry, College of Sciences, Baghdad University, Baghdad, Iraq
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Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.
Testosterone, Metformin, Glyburide, Type 2DM
To cite this article
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Salah A. Al-Windy, Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus, International Journal of Diabetes and Endocrinology. Vol. 1, No. 1, 2016, pp. 8-12. doi: 10.11648/j.ijde.20160101.12
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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