International Journal of Diabetes and Endocrinology

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Thymic Neuroendocrine Tumour Results Cushing’s Syndrome

Received: 05 August 2019    Accepted: 05 November 2019    Published: 12 November 2019
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Abstract

Background: Thymic Neuroendocrine Tumor (TNET) is a rare clinical condition with approximate incidence rate of 2–5%. Carcinoid tumor of thymus with Cushing’s syndrome (CS) is also a rare co-morbid condition. Case information: Here we report a case of a 22-year-old gentleman presented with uncommon features suggestive of CS. He was evaluated and diagnosed with ectopic Adrenocorticotropic hormone (ACTH)–dependent CS due to a TNET. Results: Extensive thymectomy was performed and histopathology confirmed the diagnosis of thymic carcinoma with neuroendocrine differentiation and local and pericardial invasion. Conclusion: Thymic carcinomas may present with symptoms due to mass effect but Cushing syndrome is the most common endocrine manifestation of these tumors. Surgery is the most effective treatment of thymic carcinoma, although chemotherapy and radiotherapy also have been reported to be effective in some cases.

DOI 10.11648/j.ijde.20190404.12
Published in International Journal of Diabetes and Endocrinology (Volume 4, Issue 4, December 2019)
Page(s) 98-103
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cushing's Syndrome, Thymic Carcinoma, Neuroendocrine Tumor

References
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Author Information
  • Department of Endocrinology, Tabriz University of Medical Sciences, Tabriz, Iran

  • Department of Surgery, Tabriz University of Medical Sciences, Tabriz, Iran

  • Department of Endocrinology, Tabriz University of Medical Sciences, Tabriz, Iran

  • Department of Endocrinology, Tabriz University of Medical Sciences, Tabriz, Iran

  • Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran

  • Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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  • APA Style

    Taher Manzary, Amir Teimouri Dereshgi, Vahideh Sadra, Ali Jamshidi Fard, Leila Teimouri Dereshgi, et al. (2019). Thymic Neuroendocrine Tumour Results Cushing’s Syndrome. International Journal of Diabetes and Endocrinology, 4(4), 98-103. https://doi.org/10.11648/j.ijde.20190404.12

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    ACS Style

    Taher Manzary; Amir Teimouri Dereshgi; Vahideh Sadra; Ali Jamshidi Fard; Leila Teimouri Dereshgi, et al. Thymic Neuroendocrine Tumour Results Cushing’s Syndrome. Int. J. Diabetes Endocrinol. 2019, 4(4), 98-103. doi: 10.11648/j.ijde.20190404.12

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    AMA Style

    Taher Manzary, Amir Teimouri Dereshgi, Vahideh Sadra, Ali Jamshidi Fard, Leila Teimouri Dereshgi, et al. Thymic Neuroendocrine Tumour Results Cushing’s Syndrome. Int J Diabetes Endocrinol. 2019;4(4):98-103. doi: 10.11648/j.ijde.20190404.12

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  • @article{10.11648/j.ijde.20190404.12,
      author = {Taher Manzary and Amir Teimouri Dereshgi and Vahideh Sadra and Ali Jamshidi Fard and Leila Teimouri Dereshgi and Touba Tarvirdizadeh},
      title = {Thymic Neuroendocrine Tumour Results Cushing’s Syndrome},
      journal = {International Journal of Diabetes and Endocrinology},
      volume = {4},
      number = {4},
      pages = {98-103},
      doi = {10.11648/j.ijde.20190404.12},
      url = {https://doi.org/10.11648/j.ijde.20190404.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijde.20190404.12},
      abstract = {Background: Thymic Neuroendocrine Tumor (TNET) is a rare clinical condition with approximate incidence rate of 2–5%. Carcinoid tumor of thymus with Cushing’s syndrome (CS) is also a rare co-morbid condition. Case information: Here we report a case of a 22-year-old gentleman presented with uncommon features suggestive of CS. He was evaluated and diagnosed with ectopic Adrenocorticotropic hormone (ACTH)–dependent CS due to a TNET. Results: Extensive thymectomy was performed and histopathology confirmed the diagnosis of thymic carcinoma with neuroendocrine differentiation and local and pericardial invasion. Conclusion: Thymic carcinomas may present with symptoms due to mass effect but Cushing syndrome is the most common endocrine manifestation of these tumors. Surgery is the most effective treatment of thymic carcinoma, although chemotherapy and radiotherapy also have been reported to be effective in some cases.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Thymic Neuroendocrine Tumour Results Cushing’s Syndrome
    AU  - Taher Manzary
    AU  - Amir Teimouri Dereshgi
    AU  - Vahideh Sadra
    AU  - Ali Jamshidi Fard
    AU  - Leila Teimouri Dereshgi
    AU  - Touba Tarvirdizadeh
    Y1  - 2019/11/12
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ijde.20190404.12
    DO  - 10.11648/j.ijde.20190404.12
    T2  - International Journal of Diabetes and Endocrinology
    JF  - International Journal of Diabetes and Endocrinology
    JO  - International Journal of Diabetes and Endocrinology
    SP  - 98
    EP  - 103
    PB  - Science Publishing Group
    SN  - 2640-1371
    UR  - https://doi.org/10.11648/j.ijde.20190404.12
    AB  - Background: Thymic Neuroendocrine Tumor (TNET) is a rare clinical condition with approximate incidence rate of 2–5%. Carcinoid tumor of thymus with Cushing’s syndrome (CS) is also a rare co-morbid condition. Case information: Here we report a case of a 22-year-old gentleman presented with uncommon features suggestive of CS. He was evaluated and diagnosed with ectopic Adrenocorticotropic hormone (ACTH)–dependent CS due to a TNET. Results: Extensive thymectomy was performed and histopathology confirmed the diagnosis of thymic carcinoma with neuroendocrine differentiation and local and pericardial invasion. Conclusion: Thymic carcinomas may present with symptoms due to mass effect but Cushing syndrome is the most common endocrine manifestation of these tumors. Surgery is the most effective treatment of thymic carcinoma, although chemotherapy and radiotherapy also have been reported to be effective in some cases.
    VL  - 4
    IS  - 4
    ER  - 

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