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Intrusion of Herbal Antilipidemics – Cardiac Protective Through Electromagnetic Thermal Device Patches

Received: 30 September 2017    Accepted: 17 October 2017    Published: 23 November 2017
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Abstract

Objective: Development of an innovated, economic and simple herbal formulation as cardiac protective through designed electromagnetic thermal device patches which induced the drugs directly to coronary arteries. This opens the blocked vessels even between 50-80% without Coronary artery bypass grafting (CABG). Material & Methods: The electromagnetic thermal device is designed with polysiloxane adhesive tape, centrally mounted with PVC membrane and over that consists of drug reservoir and in top embedded with electromagnetic vibrator. Drug use to be injected with micro-syringe and patch is operated with remote control. So, the generated heat and vibration penetrates the drug (Allicin & Arjuna) directly, vertically to coronary arteries (CA) under pericardium membrane, stored in pericardium fluid. Finally a high concentration of drugs opens the lipid choked in CA. Result & Discussion: Before and after cardiac patch drug delivery therapy ECG report, TMT, Doppler test, Angiogram analysis with the help of graphics and images, has been carried-out to evaluate the % of blockage opened. The comparative study of opening of vascular blockage through this new mechanics against other conventional drugs and CABG which proves its superior valuation. Due to herbal nature of drug contents and without any mechanical invasion, it has no adverse effects and drug interaction. Conclusion: The new innovated designed cardiac patches open the coronary artery blockage in very simply, economically, without medication error, without side effects due to herbal origin and treatment without surgery. This concludes globally emergence of the first time innovated cardiac patches convenience to patient world in medical science.

Published in Cardiology and Cardiovascular Research (Volume 1, Issue 4)
DOI 10.11648/j.ccr.20170104.12
Page(s) 104-112
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Electromagnetic Cardiac Patch, Atherosclerosis, Coronary Artery Blockage, Non-Invasive Therapy, Innovative Intrusion of Cardiac Drugs

References
[1] Anna L. H., Madeleine N., Benjamin B., Richard S. Outcomes of coronary artery bypass graft Surgery. Vascular Health and Risk Management 2006: 2(4) 477–484.
[2] Henderson RA, Jarvis C, Clayton T, Pocock SJ, Fox KAA. 10-year mortality outcome of a routine invasive strategy versus a selective invasive strategy in non-ST-segment elevation acute coronary syndrome: the British Heart Foundation RITA-3 randomized trial. J Am College of Cardiology, 2015; 66: 5; 11–20.
[3] Fox KAA, Clayton TC, Damman P, et al. Long-term outcome of a routine versus selective invasive strategy in patients with non-ST-segment elevation acute coronary syndrome: a meta-analysis of individual patient data. J Am College of Cardiology, 2010; 55: 24; 35–45.
[4] Eagle KA, Lim MJ, Dabbous OH, et al. A validated prediction model for all forms of acute coronary syndrome. JAMA 2004; 291: 2727–33.
[5] Gray HH, Henderson RA, de Belder MA, Underwood SR, Camm AJ. Early management of unstable angina and non-ST-segment elevation myocardial infarction: summary of NICE guidance. Heart 2010; 96: 1662–8.
[6] Kureshi F, Jones PG, Buchanan DM, Abdallah MS, Spertus JA. Variation in patients’ perceptions of elective percutaneous coronary intervention in stable coronary artery disease: cross sectional study. BMJ 2014; 349: 5309.
[7] M. Diodato and E. G. Chedrawy. Coronary Artery Bypass Graft Surgery: The Past, Present, and Future of Myocardial Revascularization. Surgery Research and Practice, Volume 2014, Article ID 726158, 6 pages (http://dx.doi.org/10.1155/2014/726158).
[8] Gaikwad A. K. Transdermal drug delivery system: Formulation aspects and evaluation. Comprehensive Journal of Pharmaceutical Sciences. 2013; 1 (1); 1 - 10.
[9] Nirav S Sheth, Rajan B Mistry. Formulation and evaluation of transdermal patches and to study permeation enhancement effect of eugenol. Journal of Applied Pharmaceutical Science, 2011: 1 (3); 96-101.
[10] D. Patel, Sunita A. Chaudhary, B. Parmar, N. Bhura. Transdermal Drug Delivery System: A Review. The Pharma Innovation. 2012, 1 (4), 66-76.
[11] Latheeshjlal. L, P. Phanitejaswini, Y. Soujanya, U. Swapna, V. Sarika, G. Moulika. Transdermal Drug Delivery Systems: An Overview. Int. J. Pharm Tech Res. 2011, 3 (4), 2140-48.
[12] S. Dhiman, T. G Singh and A. K. Rehni. Transdermal patches: A recent approach to new drug delivery system. Int J Pharm Pharm Sci, 3 (5), 26-34.
[13] K. Hansen, et al. Microneedles as a transformative technology in drug delivery. Copyright © 2013 Frederick Furness Publishing Ltd, page 8-10.
[14] Gill H, Prausnitz MR. Coated micro needles for Transdermal Delivery. J Control Release, 2007, 11 (7), 227–237.
[15] Lee JW, Park J-H, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials, 2008, 29, 2113–2124.
[16] Teo A, Shearwood C, Ng K, Lu J, Moochhala S. Transdermal micro needles for drug delivery application. Materials Sci. Eng, 2006, 13 (2), 151–154.
[17] Stoeber B, Liepmann D. Arrays of hollow out-of-plane microneedles for drug delivery. J Microelectromechanical Systems, 2005, 14, 472–479.
[18] Yung K, Xu Y, Liu H, Tam K, Ko S, Kwan F, Lee Y, Sharp-tipped plastic hollow microneedle array by microinjection moulding. J Micromechanical Micro eng, 2012, 22, 1–10.
[19] Lhernould MS, Delchambre A. Innovative design of hollow polymeric microneedles for transdermal drug delivery. Microsystem Technol, 2011, 17, 1675–1682.
[20] Burton S, Moeckly C, Brandwein D, Gilbert T et al. Rapid intradermal delivery of liquid formulations using a hollow microstructured array. Pharm Res, 2011, 28, 31–40.
[21] Lhernould MS, Lambert P. Compact polymer multinozzle electrospray device with integrated microfluidic feeding system. J Electrost. 2011, 69, 313–319.
[22] Verbaan F, Van den Berg D, Dijksman J. Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method. J Control Release, 2008, 128, 80–88.
[23] Pacini S, Punzi T, Gulisano M. Transdermal delivery of Hyaluronicaci. J of Dermatology Sc, 2006, 44, 169-171.
[24] Pacini S, Punzi T, Gulisano M. Transdermal delivery of Clostridium Botulinum Toxin Type A by pulsed current Iontophoresis. Poster Presented at 65th Annual Meeting of the American Academy of Dermatology, 2007, Washington DC, US.
[25] Pacini S., Punzi T, Gulisano M et al. Transdermal deliveryof heparin using pulsed current inotophoresis. Pharm Research, 2006, 23 (1), 114-120.
[26] Pacini S, Peruzzi B, Gulisano M. Qualitative and quantitative analysis of transdermic delivery of different biological molecules by iontophoresis. Italian Journal of Analt Embryol, 2003, 18 (2), 127–129.
[27] Pacini S., Peruzzi B, Gulisano M et al. Transdermal delivery of heparin by means of alternate current skin electroporation”. Ital J Anat Embryol, 2004, 109 (1), 223.
[28] De Bartolo HM, “Comparison of Mattioli Iontophoresis, Mesosystems, the U225, and Manual Injections”. Proceedings of the Illinois Society of Ophtalmology & Otolaryngology, 2005, Vol 9 (1).
[29] De Bartolo HM, “Scar Revision &Minimally Invasive Cosmetic Surgery using Mattioli Engineering Technology”, ibid.
[30] Bacci PA, “The role of Dermo electroporation”. Cellulite: Pathphysiology & Treatment, 2006, Chapter 18, pp 291-299. (Published by Taylor & Francis, ISBN-10: 0-8247-2985-4/ISBN-13: 978-0-8247-2985).
[31] Gonen A, Harats D, Rabinkov A, Miron T, et al. The antiatherogenic effect of allicin: possible mode of action. Pathobiology. 2005; 72 (6): 325-34.
[32] Laham RJ, Simons M, Hung D et al. Subxyphoid access of the normal pericardium: a novel drug delivery technique. Catheter Cardiovasc Interv. 1999 May; 47 (1): 109-11.
[33] Theofilos M. Kolettis, Nikolaos Kazakos, Christos S. Katsouras et al. Intrapericardial drug delivery: pharmacologic properties and long-term safety in swine. Int J Cardiol. 2005 Mar 30; 99 (3): 415-21.
Cite This Article
  • APA Style

    Rakesh Das, Sudhanshu Chakraborty. (2017). Intrusion of Herbal Antilipidemics – Cardiac Protective Through Electromagnetic Thermal Device Patches. Cardiology and Cardiovascular Research, 1(4), 104-112. https://doi.org/10.11648/j.ccr.20170104.12

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    ACS Style

    Rakesh Das; Sudhanshu Chakraborty. Intrusion of Herbal Antilipidemics – Cardiac Protective Through Electromagnetic Thermal Device Patches. Cardiol. Cardiovasc. Res. 2017, 1(4), 104-112. doi: 10.11648/j.ccr.20170104.12

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    AMA Style

    Rakesh Das, Sudhanshu Chakraborty. Intrusion of Herbal Antilipidemics – Cardiac Protective Through Electromagnetic Thermal Device Patches. Cardiol Cardiovasc Res. 2017;1(4):104-112. doi: 10.11648/j.ccr.20170104.12

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  • @article{10.11648/j.ccr.20170104.12,
      author = {Rakesh Das and Sudhanshu Chakraborty},
      title = {Intrusion of Herbal Antilipidemics – Cardiac Protective Through Electromagnetic Thermal Device Patches},
      journal = {Cardiology and Cardiovascular Research},
      volume = {1},
      number = {4},
      pages = {104-112},
      doi = {10.11648/j.ccr.20170104.12},
      url = {https://doi.org/10.11648/j.ccr.20170104.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20170104.12},
      abstract = {Objective: Development of an innovated, economic and simple herbal formulation as cardiac protective through designed electromagnetic thermal device patches which induced the drugs directly to coronary arteries. This opens the blocked vessels even between 50-80% without Coronary artery bypass grafting (CABG). Material & Methods: The electromagnetic thermal device is designed with polysiloxane adhesive tape, centrally mounted with PVC membrane and over that consists of drug reservoir and in top embedded with electromagnetic vibrator. Drug use to be injected with micro-syringe and patch is operated with remote control. So, the generated heat and vibration penetrates the drug (Allicin & Arjuna) directly, vertically to coronary arteries (CA) under pericardium membrane, stored in pericardium fluid. Finally a high concentration of drugs opens the lipid choked in CA. Result & Discussion: Before and after cardiac patch drug delivery therapy ECG report, TMT, Doppler test, Angiogram analysis with the help of graphics and images, has been carried-out to evaluate the % of blockage opened. The comparative study of opening of vascular blockage through this new mechanics against other conventional drugs and CABG which proves its superior valuation. Due to herbal nature of drug contents and without any mechanical invasion, it has no adverse effects and drug interaction. Conclusion: The new innovated designed cardiac patches open the coronary artery blockage in very simply, economically, without medication error, without side effects due to herbal origin and treatment without surgery. This concludes globally emergence of the first time innovated cardiac patches convenience to patient world in medical science.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Intrusion of Herbal Antilipidemics – Cardiac Protective Through Electromagnetic Thermal Device Patches
    AU  - Rakesh Das
    AU  - Sudhanshu Chakraborty
    Y1  - 2017/11/23
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ccr.20170104.12
    DO  - 10.11648/j.ccr.20170104.12
    T2  - Cardiology and Cardiovascular Research
    JF  - Cardiology and Cardiovascular Research
    JO  - Cardiology and Cardiovascular Research
    SP  - 104
    EP  - 112
    PB  - Science Publishing Group
    SN  - 2578-8914
    UR  - https://doi.org/10.11648/j.ccr.20170104.12
    AB  - Objective: Development of an innovated, economic and simple herbal formulation as cardiac protective through designed electromagnetic thermal device patches which induced the drugs directly to coronary arteries. This opens the blocked vessels even between 50-80% without Coronary artery bypass grafting (CABG). Material & Methods: The electromagnetic thermal device is designed with polysiloxane adhesive tape, centrally mounted with PVC membrane and over that consists of drug reservoir and in top embedded with electromagnetic vibrator. Drug use to be injected with micro-syringe and patch is operated with remote control. So, the generated heat and vibration penetrates the drug (Allicin & Arjuna) directly, vertically to coronary arteries (CA) under pericardium membrane, stored in pericardium fluid. Finally a high concentration of drugs opens the lipid choked in CA. Result & Discussion: Before and after cardiac patch drug delivery therapy ECG report, TMT, Doppler test, Angiogram analysis with the help of graphics and images, has been carried-out to evaluate the % of blockage opened. The comparative study of opening of vascular blockage through this new mechanics against other conventional drugs and CABG which proves its superior valuation. Due to herbal nature of drug contents and without any mechanical invasion, it has no adverse effects and drug interaction. Conclusion: The new innovated designed cardiac patches open the coronary artery blockage in very simply, economically, without medication error, without side effects due to herbal origin and treatment without surgery. This concludes globally emergence of the first time innovated cardiac patches convenience to patient world in medical science.
    VL  - 1
    IS  - 4
    ER  - 

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Author Information
  • Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, Kolkata, India

  • School of Medical Sc. & Technology, Indian Institute of Technology (Kharagpur), Kharagpur, India

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