Cardiology and Cardiovascular Research

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Relation Between Serum Ferritin Level and the Left Ventricular Mass Index (LVMI) in Maintenance Hemodialysis Patients

Received: 05 November 2018    Accepted: 16 November 2018    Published: 19 December 2018
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Abstract

Among hemodialysis (HD) patients, the left ventricular hypertrophy (LVH) is a common cardiovascular morbidity predictor. Ferritin level was considered as a clinical marker of iron storage and associated with cardiovascular mortality in chronic kidney disease (CKD) patients. The relationship between ferritin level and cardiac function in maintenance hemodialysis patients has not yet fully investigated. This study aimed to investigate the relationship between serum ferritin level and left ventricular mass index (LVMi) in hemodialysis patients. In this study, 70 regular chronic hemodialysis patients were included in a cross-sectional study (43 men and 27 women). The patients were sub-grouped into two groups according to the ferritin levels (patients with serum ferritin <800ng/ml (n=40), and patients with serum ferritin ≥800ng/ml (n=30)). Left ventricular mass (LVM), Left ventricular mass index (LVMi) and Left ventricular mass/hight 2.7 (LVM/Ht2.7) were evaluated by echocardiography. The patients with serum ferritin level ≥800 ng/ml showed significantly higher LVM, LVMI and LVM/Ht2.7 than other group. LVM, LVMI and LVM/Ht2.7 were significantly correlated to ferritin and hs-CRP. Regarding to the linear regression analysis, serum ferritin level was founded to be an independent predictors of LVM/Ht2.7 and but not for LVM nor LVMi. While, Highly sensitive C-reactive protein (hs-CRP) was founded to be independent predictors of LVM, LVMi and LVM/Ht2.7. This study showed that LVM, LVMI and LVM/ Ht2.7 are significantly elevated in patients with serum ferritin level ≥800 ng/ml. The serum ferritin was found to be independent predictors of LVH (represented by LVM/ Ht2.7) in maintenance HD patients.

DOI 10.11648/j.ccr.20180204.15
Published in Cardiology and Cardiovascular Research (Volume 2, Issue 4, December 2018)
Page(s) 98-103
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Left Ventricular Mass Index, Ferritin, Hemodialysis, Echocardiography

References
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Author Information
  • Nephrology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Department of Cardiovascular Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Nephrology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Nephrology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Nephrology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Department of Cardiovascular Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt

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  • APA Style

    Ahmed Eldeeb, Ahmed Hosny El-Adawy, Elshahat Yousef, Ahmed Ibrahim, Mostafa Anis Mahmoud, et al. (2018). Relation Between Serum Ferritin Level and the Left Ventricular Mass Index (LVMI) in Maintenance Hemodialysis Patients. Cardiology and Cardiovascular Research, 2(4), 98-103. https://doi.org/10.11648/j.ccr.20180204.15

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    ACS Style

    Ahmed Eldeeb; Ahmed Hosny El-Adawy; Elshahat Yousef; Ahmed Ibrahim; Mostafa Anis Mahmoud, et al. Relation Between Serum Ferritin Level and the Left Ventricular Mass Index (LVMI) in Maintenance Hemodialysis Patients. Cardiol. Cardiovasc. Res. 2018, 2(4), 98-103. doi: 10.11648/j.ccr.20180204.15

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    AMA Style

    Ahmed Eldeeb, Ahmed Hosny El-Adawy, Elshahat Yousef, Ahmed Ibrahim, Mostafa Anis Mahmoud, et al. Relation Between Serum Ferritin Level and the Left Ventricular Mass Index (LVMI) in Maintenance Hemodialysis Patients. Cardiol Cardiovasc Res. 2018;2(4):98-103. doi: 10.11648/j.ccr.20180204.15

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  • @article{10.11648/j.ccr.20180204.15,
      author = {Ahmed Eldeeb and Ahmed Hosny El-Adawy and Elshahat Yousef and Ahmed Ibrahim and Mostafa Anis Mahmoud and Hany Abdel Shakour and Mohamed Omran},
      title = {Relation Between Serum Ferritin Level and the Left Ventricular Mass Index (LVMI) in Maintenance Hemodialysis Patients},
      journal = {Cardiology and Cardiovascular Research},
      volume = {2},
      number = {4},
      pages = {98-103},
      doi = {10.11648/j.ccr.20180204.15},
      url = {https://doi.org/10.11648/j.ccr.20180204.15},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ccr.20180204.15},
      abstract = {Among hemodialysis (HD) patients, the left ventricular hypertrophy (LVH) is a common cardiovascular morbidity predictor. Ferritin level was considered as a clinical marker of iron storage and associated with cardiovascular mortality in chronic kidney disease (CKD) patients. The relationship between ferritin level and cardiac function in maintenance hemodialysis patients has not yet fully investigated. This study aimed to investigate the relationship between serum ferritin level and left ventricular mass index (LVMi) in hemodialysis patients. In this study, 70 regular chronic hemodialysis patients were included in a cross-sectional study (43 men and 27 women). The patients were sub-grouped into two groups according to the ferritin levels (patients with serum ferritin 2.7 (LVM/Ht2.7) were evaluated by echocardiography. The patients with serum ferritin level ≥800 ng/ml showed significantly higher LVM, LVMI and LVM/Ht2.7 than other group. LVM, LVMI and LVM/Ht2.7 were significantly correlated to ferritin and hs-CRP. Regarding to the linear regression analysis, serum ferritin level was founded to be an independent predictors of LVM/Ht2.7 and but not for LVM nor LVMi. While, Highly sensitive C-reactive protein (hs-CRP) was founded to be independent predictors of LVM, LVMi and LVM/Ht2.7. This study showed that LVM, LVMI and LVM/ Ht2.7 are significantly elevated in patients with serum ferritin level ≥800 ng/ml. The serum ferritin was found to be independent predictors of LVH (represented by LVM/ Ht2.7) in maintenance HD patients.},
     year = {2018}
    }
    

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    T1  - Relation Between Serum Ferritin Level and the Left Ventricular Mass Index (LVMI) in Maintenance Hemodialysis Patients
    AU  - Ahmed Eldeeb
    AU  - Ahmed Hosny El-Adawy
    AU  - Elshahat Yousef
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    AU  - Hany Abdel Shakour
    AU  - Mohamed Omran
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    JF  - Cardiology and Cardiovascular Research
    JO  - Cardiology and Cardiovascular Research
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    PB  - Science Publishing Group
    SN  - 2578-8914
    UR  - https://doi.org/10.11648/j.ccr.20180204.15
    AB  - Among hemodialysis (HD) patients, the left ventricular hypertrophy (LVH) is a common cardiovascular morbidity predictor. Ferritin level was considered as a clinical marker of iron storage and associated with cardiovascular mortality in chronic kidney disease (CKD) patients. The relationship between ferritin level and cardiac function in maintenance hemodialysis patients has not yet fully investigated. This study aimed to investigate the relationship between serum ferritin level and left ventricular mass index (LVMi) in hemodialysis patients. In this study, 70 regular chronic hemodialysis patients were included in a cross-sectional study (43 men and 27 women). The patients were sub-grouped into two groups according to the ferritin levels (patients with serum ferritin 2.7 (LVM/Ht2.7) were evaluated by echocardiography. The patients with serum ferritin level ≥800 ng/ml showed significantly higher LVM, LVMI and LVM/Ht2.7 than other group. LVM, LVMI and LVM/Ht2.7 were significantly correlated to ferritin and hs-CRP. Regarding to the linear regression analysis, serum ferritin level was founded to be an independent predictors of LVM/Ht2.7 and but not for LVM nor LVMi. While, Highly sensitive C-reactive protein (hs-CRP) was founded to be independent predictors of LVM, LVMi and LVM/Ht2.7. This study showed that LVM, LVMI and LVM/ Ht2.7 are significantly elevated in patients with serum ferritin level ≥800 ng/ml. The serum ferritin was found to be independent predictors of LVH (represented by LVM/ Ht2.7) in maintenance HD patients.
    VL  - 2
    IS  - 4
    ER  - 

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