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Dobutamine Stress Echocardiography in Chronic Kidney Disease Patients Candidates for Renal Transplantation

Received: 5 September 2020    Accepted: 17 September 2020    Published: 23 September 2020
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Abstract

Background: Dobutamine stress echocardiography (DSE) is used for induction of ischemia in different population. One of those is chronic kidney disease patients before renal transplantation for pre-operative risk assessment. Aim of the work: to evaluate the difference in dobutamine stress echocardiography between those with chronic kidney disease (CKD) on regular dialysis and patient with no known history of chronic renal impairment. Methods: From February 2016 to January 2017, twenty consecutive chronic kidney disease patients prepared for renal transplantation without history suggestive of ischemic heart disease and 40 consecutive patients with without history of renal impairment. Their heart rate, dobutamine dose, atropine dose and adverse side effects were compared between the two groups. Results: Both groups were matched in age and risk factors. Peak heart rate (HR) (133.7±16.99 vs. 144.08±10.99 b/m, P=0.012), time to target heart rate was (17.75±3.29 vs. 13.05±2.95 min, p=0.001) and dobutamine and atropine doses were higher in chronic kidney disease group than other group. Adverse reactions present in both groups but more incidence in CKD group. Conclusion: Chronic kidney disease patients response to dobutamine when underwent dobutamine stress echocardiography showed delayed effect of it with more dobutamine and atropine doses needed and more adverse reactions including Bezold-Jarisch reflex.

Published in Cardiology and Cardiovascular Research (Volume 4, Issue 3)
DOI 10.11648/j.ccr.20200403.22
Page(s) 164-168
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Dobutamine Stress Echocardiography, Chronic Kidney Disease, Bezold-Jarisch Reflex

References
[1] U.S. Renal Data System. USRDS 2011 annual data report: Atlas of chronic kidney disease and end-stage renal disease in the United States. 2011.
[2] Bangalore S: Stress testing in patients with chronic kidney disease: The need for ancillary markers for effective risk stratification and prognosis. Journal of Nuclear Cardiology. 2016; 23; 570–574.
[3] Go AS, Chertow GM, Fan D, et al.: Chronic kidney disease and the risks of death, cardiovascular events and hospitalization. N Engl J Med 2004; 351: 1296–305.
[4] Schmidt A, Stefenelli T, Schuster E, et al.: Informational contribution of noninvasive screening tests for coronary artery disease in patients on chronic renal replacement therapy. Am J Kidney Dis. 2001; 37: 56–63.
[5] Fleisher LA, Fleischmann KE, Auerbach AD, et al.: 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014; 64: e77–e137.
[6] Lentine KL, Costa SP, Weir MR, et al.: Cardiac disease evaluation and management among kidney and liver transplantation candidates: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2012; 60: 434–480.
[7] Karthikeyan V, Ananthasubramaniam K: Coronary risk assessment and management options in chronic kidney disease patients prior to kidney transplantation. Curr Cardiol Rev. 2009; 5 (3): 177-186. doi: 10.2174/157340309788970342.
[8] Lang RM, Badano LP, Mor-Avi V, et al.: Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of echocardiography and the European Association of Cardiovascular imaging. J Am Soc Echocardiogr. 2015; 28: 1-39 e14.
[9] Pellikka P, Nagueh S, Elhendy A, et al.: American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography. J Am Soc Echocardiogr. 2007; 20: 1021-1041.
[10] Lim YC, Teo SG, Poh KK: ST-segment changes with exercise stress. Singapore Med J. 2016; 57 (7): 347-353. doi: 10.11622/smedj.2016116.
[11] Senior R, Lahiri A: Enhanced detection of myocardial ischemia by stress dobutamine echocardiography utilizing the “biphasic” response of wall thickening during low and high dose dobutamine infusion. J Am Coll Cardiol 1995; 26: 26-32.
[12] Parent ME, Lepage S: A Heart Stopping Case of the Bezold-Jarisch Reflex. Case Rep Cardiol. 2015; 2015: 359401. doi: 10.1155/2015/359401.
[13] Bhatti NK, Karimi GK, Paz Y, et al.: Diagnosis and Management of Cardiovascular Disease in Advanced and End-Stage Renal Disease. J Am Heart Assoc. 2016; 5 (8): e003648. doi: 10.1161/JAHA.116.003648.
[14] Shirani J, Meera S, Dilsizian V: The Cardiorenal Axis: Myocardial Perfusion, Metabolism, and Innervation. Current Cardiology Reports. 2019; 21: 60.
[15] Wang LW, Fahim MA, Hayen A, et al.: Cardiac testing for coronary artery disease in potential kidney transplant recipients: a systematic review of test accuracy studies. Am J Kidney Dis. 2011; 57: 476–487.
[16] Sharma R, Pellerin D, Gaze DC, et al.: Dobutamine stress echocardiography and the resting but not exercise electrocardiograph predict severe coronary artery disease in renal transplant candidates. Nephrology Dialysis Transplantation. 2005; 20 (10): 2207–2214. https://doi.org/10.1093/ndt/gfi005.
[17] Rakhit DJ, Armstrong KA, MAppStat EB, et al.: Risk stratification of patients with chronic kidney disease: Results of screening strategies incorporating clinical risk scoring and dobutamine stress echocardiography American Heart Journal. 2006: 152 (2): 363-370.
[18] Bergeron S, Hillis GS, Haugen EN, et al.: Prognostic value of dobutamine stress echocardiography in patients with chronic kidney disease. Am Heart J. 2007; 153: 385–391.
[19] Ramphul R, Fernandez M, Firoozi S, et al.: Assessing cardiovascular risk in chronic kidney disease patients prior to kidney transplantation: clinical usefulness of a standardised cardiovascular assessment protocol. BMC Nephrology. 2018: 19: 2.
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  • APA Style

    Abdel Mohsen Mostafa Aboualia. (2020). Dobutamine Stress Echocardiography in Chronic Kidney Disease Patients Candidates for Renal Transplantation. Cardiology and Cardiovascular Research, 4(3), 164-168. https://doi.org/10.11648/j.ccr.20200403.22

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    ACS Style

    Abdel Mohsen Mostafa Aboualia. Dobutamine Stress Echocardiography in Chronic Kidney Disease Patients Candidates for Renal Transplantation. Cardiol. Cardiovasc. Res. 2020, 4(3), 164-168. doi: 10.11648/j.ccr.20200403.22

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    AMA Style

    Abdel Mohsen Mostafa Aboualia. Dobutamine Stress Echocardiography in Chronic Kidney Disease Patients Candidates for Renal Transplantation. Cardiol Cardiovasc Res. 2020;4(3):164-168. doi: 10.11648/j.ccr.20200403.22

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  • @article{10.11648/j.ccr.20200403.22,
      author = {Abdel Mohsen Mostafa Aboualia},
      title = {Dobutamine Stress Echocardiography in Chronic Kidney Disease Patients Candidates for Renal Transplantation},
      journal = {Cardiology and Cardiovascular Research},
      volume = {4},
      number = {3},
      pages = {164-168},
      doi = {10.11648/j.ccr.20200403.22},
      url = {https://doi.org/10.11648/j.ccr.20200403.22},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20200403.22},
      abstract = {Background: Dobutamine stress echocardiography (DSE) is used for induction of ischemia in different population. One of those is chronic kidney disease patients before renal transplantation for pre-operative risk assessment. Aim of the work: to evaluate the difference in dobutamine stress echocardiography between those with chronic kidney disease (CKD) on regular dialysis and patient with no known history of chronic renal impairment. Methods: From February 2016 to January 2017, twenty consecutive chronic kidney disease patients prepared for renal transplantation without history suggestive of ischemic heart disease and 40 consecutive patients with without history of renal impairment. Their heart rate, dobutamine dose, atropine dose and adverse side effects were compared between the two groups. Results: Both groups were matched in age and risk factors. Peak heart rate (HR) (133.7±16.99 vs. 144.08±10.99 b/m, P=0.012), time to target heart rate was (17.75±3.29 vs. 13.05±2.95 min, p=0.001) and dobutamine and atropine doses were higher in chronic kidney disease group than other group. Adverse reactions present in both groups but more incidence in CKD group. Conclusion: Chronic kidney disease patients response to dobutamine when underwent dobutamine stress echocardiography showed delayed effect of it with more dobutamine and atropine doses needed and more adverse reactions including Bezold-Jarisch reflex.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Dobutamine Stress Echocardiography in Chronic Kidney Disease Patients Candidates for Renal Transplantation
    AU  - Abdel Mohsen Mostafa Aboualia
    Y1  - 2020/09/23
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ccr.20200403.22
    DO  - 10.11648/j.ccr.20200403.22
    T2  - Cardiology and Cardiovascular Research
    JF  - Cardiology and Cardiovascular Research
    JO  - Cardiology and Cardiovascular Research
    SP  - 164
    EP  - 168
    PB  - Science Publishing Group
    SN  - 2578-8914
    UR  - https://doi.org/10.11648/j.ccr.20200403.22
    AB  - Background: Dobutamine stress echocardiography (DSE) is used for induction of ischemia in different population. One of those is chronic kidney disease patients before renal transplantation for pre-operative risk assessment. Aim of the work: to evaluate the difference in dobutamine stress echocardiography between those with chronic kidney disease (CKD) on regular dialysis and patient with no known history of chronic renal impairment. Methods: From February 2016 to January 2017, twenty consecutive chronic kidney disease patients prepared for renal transplantation without history suggestive of ischemic heart disease and 40 consecutive patients with without history of renal impairment. Their heart rate, dobutamine dose, atropine dose and adverse side effects were compared between the two groups. Results: Both groups were matched in age and risk factors. Peak heart rate (HR) (133.7±16.99 vs. 144.08±10.99 b/m, P=0.012), time to target heart rate was (17.75±3.29 vs. 13.05±2.95 min, p=0.001) and dobutamine and atropine doses were higher in chronic kidney disease group than other group. Adverse reactions present in both groups but more incidence in CKD group. Conclusion: Chronic kidney disease patients response to dobutamine when underwent dobutamine stress echocardiography showed delayed effect of it with more dobutamine and atropine doses needed and more adverse reactions including Bezold-Jarisch reflex.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • Cardiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

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