A Review of Composition and Health Effects of Lycium barbarum
International Journal of Chinese Medicine
Volume 1, Issue 1, January 2017, Pages: 1-9
Received: Dec. 24, 2016; Accepted: Jan. 5, 2017; Published: Jan. 24, 2017
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Emine Kocyigit, Faculty of Health Sciences, Nutrition and Dietetic Department, Ankara, Turkey
Nevin Sanlier, Faculty of Health Sciences, Nutrition and Dietetic Department, Ankara, Turkey
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Lycium barbarum has a radical place in traditional Chinese medicine, also draws attention due to the potential health benefits in recent years. The antioxidant effects of Lycium barbarum have been studied in many aspects: as an anti-aging agent, for general health protection, against tumor growth, for the development of the immune system regulatory, to develop vision, and to protect against cancer and diabetes. High amounts of polysaccharide and carotenoid content are the main components of the antioxidant activity. The structure also contains a high percentage of B group vitamins, such as B1, B2, B6, and minerals, such as Fe, Zn, and Cu. Although it is natively grown in China and other Asian countries, it’s also cultivated in the Mediterranean countries, North America, and Australia. In this study, the components of Lycium barbarum, their properties, and its positive and negative effects on human health are presented.
Lycium barbarum, Lycium barbarum Polysaccharide, Nutrition, Health Effect
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Emine Kocyigit, Nevin Sanlier, A Review of Composition and Health Effects of Lycium barbarum, International Journal of Chinese Medicine. Vol. 1, No. 1, 2017, pp. 1-9. doi: 10.11648/j.ijcm.20170101.11
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Lasekan O. Exotic berries as a functional food. Current Opinion in Clinical Nutrition & Metabolic Care 2014; 17 (6): 589-595.
Zhang J. Antioxidant properties of goji berry. Doctoral dissertation, Wayne State Unıversity, 2013.
Cheng J, Zhou ZW, Sheng HP, He LJ, Fan XW, He ZX, Sun T, Zhang X, Zhao RJ, Gu L, et al. An evidencebased update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug design, development and therapy 2015; 9: 33-78.
Potterat OG. Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 2010; 76 (1): 719.
Mikulic-Petkovsek M, Schmitzer V, Slatnar A, Stampar F, Veberic R. Composition of sugars, organic acids, and total phenolics in 25 wild or cultivated berry species. Journal of food science 2012; 77 (10): C1064-C1070.
Sze SCW, Song JX, Wong RNS, Feng YB, Ng TB, Tong Y, Zhang KYB. Application of SCAR (sequence characterized amplified region) analysis to authenticate Lycium barbarum (wolfberry) and its adulterants. Biotechnology and Applied Biochemistry 2008; 51: 15-21.
Redgwell RJ, Curti D, Wang J, Dobruchowska JM, Gerwig GJ, Kamerling JP, Bucheli P. Cell wall polysaccharides of Chinese Wolfberry (Lycium barbarum): Part 1. Characterisation of soluble and insoluble polymer fractions. Carbohydrate Polymers 2011; 84 (4): 1344-1349.
Endes Z, Uslu N, Özcan MM, Er F. Physicochemical properties, fatty acid composition and mineral contents of lycium barbarum (Lycium barbarum L.) fruit. Journal of Agroalimentary Processes and Technologies 2015; 21: 36-40.
United States Department of Agriculture (USDA). Nutrient Database [Internet]. [cited 2016 Mar 3]. Available from: https://ndb.nal.usda.gov/ndb/foods/show/2221?format=Full&reportfmt=pdf&pdfQvs=%7B%7D.
Tian M, Wang M. Studies on extraction, isolation and composition of Lycium barbarum polysaccharides. Zhongguo Zhong yao za zhi=Zhongguo zhongyao zazhi= China journal of Chinese materia medica 2006; 31 (19): 1603-1607.
Wang CC, Chang SC, Inbaraj BS, Chen BH. Isolation of carotenoids, flavonoids and polysaccharides from Lycium barbarum L. and evaluation of antioxidant activity. Food Chemistry 2010; 120 (1): 184-192.
Hua Ji, Hui He, Dingbo Lin. Dietary Wolfberry and Retinal Degeneration. In: Preedy VR, editor. Handbook of Nutrition, Diet and the Eye. Cambridge (England): Massachusetts Academic Press; 2014. p. 465-472.
Wang Y, Chen H, Wu M, Zeng S, Liu Y, Dong J. Chemical and Genetic Diversity of Wolfberry. In: Chang RCC, So KF, editors. Lycium Barbarum and Human Health. London (England): Springer; 2015. p. 126.
Yin G, Dang Y. Optimization of extraction technology of the Lycium barbarum polysaccharides by Box–Behnken statistical design. Carbohydrate Polymers 2008; 74 (3): 603-610.
Gogoasa I, Alda L, Rada M, Negrea P, Negrea A, Bordean DM, Draghici GA, Gergen I. Goji berries (Lycium barbarum) as a source of trace elements in human nutrition. Journal of Agroalimentary Processes and Technologies 2014; 20 (4): 369-372.
Kulczyński B, Gramza-Michałowska A. Goji berry (Lycium barbarum): Composition and Health Effects–a Review. Polish Journal of Food and Nutrition Sciences 2016; 66 (2): 67-75.
Ahmad SR, Gokulakrishnan P, Giriprasad R, Yatoo MA. Fruitbased natural antioxidants in meat and meat products: A review. Critical reviews in food science and nutrition 2015; 55 (11): 1503-1513.
Kmiecik D, Korczak J, Rudzińska M, Gramza-Michałowska A, Hęś M, Kobus-Cisowska J. Stabilisation of phytosterols by natural and synthetic antioxidants in high temperature conditions. Food chemistry 2015; 173: 966-971.
Jabbar S, Abid M, Zeng X. Nutritional, Phytochemical Characterization and Antioxidant Capacity of Ningxia Wolfberry (Lycium barbarum L.). Journal of the Chemical Society of Pakistan 2014; 36 (6): 1079-1087.
Yang X, Bai H, Cai W, Li J, Zhou Q, Wang Y, Han J, Zhu X, Dong M, Hu D. Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats. Chemicobiological interactions 2013; 204 (3): 166-172.
Haytowitz DB, Bhagwat S. Database for the oxygen radical absorbance capacity (ORAC) of selected foods, Release 2. Washington (DC): US Department of Agriculture; 2010.
Amagase H, Sun B, Borek C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutrition Research 2009; 29 (1): 19-25.
Li XM. Protective effect of Lycium barbarum polysaccharides on streptozotocininduced oxidative stress in rats. International journal of biological macromolecules 2007; 40 (5): 461-465.
Wu HT, He XJ, Hong YK, Ma T, Xu YP, Li HH. Chemical characterization of lycium barbarum polysaccharides and its inhibition against liver oxidative injury of highfat mice. International journal of biological macromolecules 2010; 46 (5): 540-543.
Ming M, Guanhua L, Zhanhai Y, Guang C, Xuan Z. Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed highfat diet in vivo. Food Chemistry 2009; 113 (4): 872-877.
Tang WM, Chan E, Kwok CY, Lee YK, Wu JH, Wan CW, Chan RYK, Yu PHF, Chan SW. A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology 2012; 20 (6): 307-314.
Chao JC, Chiang SW, Wang CC, Tsai YH, Wu MS. Hot waterextracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells. World Journal of Gastroenterol 2006; 12 (28): 447-884.
Zhu CP, Zhang SH. Lycium barbarum polysaccharide inhibits the proliferation of HeLa cells by inducing apoptosis, Journal of the Science of Food and Agriculture 2013; 93 (1): 149-156.
Mao F, Xiao B, Jiang Z, Zhao J, Huang X, Guo J. Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest. Medical Oncology 2011; 28 (1): 121-126.
Vidal K, Bucheli P, Gao Q, Moulin J, Shen LS, Wang J, Blum S, Benyacoub J. Immunomodulatory effects of dietary supplementation with a milkbased wolfberry formulation in healthy elderly: a randomized, doubleblind, placebocontrolled trial. Rejuvenation research 2012; 15 (1): 89-97.
Amagase H, Sun B, Nance DM. Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects. Journal of medicinal food 2009; 12 (5): 1159-1165.
Zhou J, Pang H, Li W, Liu Q, Xu L, Liu Q, Liu Y. Effects of Lycium barbarum Polysaccharides on Apoptosis, Cellular Adhesion, and Oxidative Damage in Bone Marrow Mononuclear Cells of Mice Exposed to Ionizing Radiation Injury. BioMed Research International 2016; 2016: 18.
Jin M, Huang Q, Zhao K, Shang P. Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L. International journal of biological macromolecules 2013; 54: 16-23.
Luo Q, Cai, Y, Yan J, Sun M, Corke H. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sciences 2004; 76 (2): 137-149.
Zhao R, Jin R, Chen Y, Han FM. Hypoglycemic and Hypolipidemic Effects of Lycium barbarum Polysaccharide in Diabetic Rats. Chinese Herbal Medicines 2015; 7: 310-315.
Cui B, Liu S, Lin X, Wang J, Li S, Wang Q, Li S. Effects of Lycium barbarum aqueous and ethanol extracts on highfatdiet induced oxidative stress in rat liver tissue. Molecules 2011; 16 (11): 9116-9128.
Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, Lu H, Guo F, Han C, Sun G. Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes. Medicinal Chemistry (Shariqah (United Arab Emirates) 2015; 11 (4): 383-390.
Du M, Hu X, Kou L, Zhang B, Zhang C. Lycium barbarum Polysaccharide Mediated the Antidiabetic and Antinephritic Effects in DietStreptozotocinInduced Diabetic Sprague Dawley Rats via Regulation of NFκB. BioMed Research International 2016; 2016: 19.
Ni T, Wei G, Yin X, Liu X, Liu D. Neuroprotective effect of Lycium barbarum on retina of Royal College of Surgeons (RCS) rats: a preliminary study. Folia Neuropathologica 2013; 51 (2): 158-163.
Amagase H, Hsu CHP. Metaanalysis of the general effects of a standardized Lycium barbarum fruit juice shown in randomized, doubleblind, placebocontrolled human clinical studies. The FASEB Journal 2009; 23 (1 Supplement): 71-61.
Amagase H, Nance DM. Improvement of sleep quality by a standardized Lycium barbarum fruit juice shown in a randomized, doubleblind, placebocontrolled human clinical study, Planta Medica 2008a; 74 (9): PH18.
Amagase H, Nance DM. A randomized, doubleblind, placebocontrolled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi™. The Journal of Alternative and Complementary Medicine 2008b; 14 (4): 403-412.
Amagase H, Farnsworth NR. A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Food Research International 2011; 44 (7): 1702-1717.
Chang RCC, So KF. Use of antiaging herbal medicine, Lycium barbarum, against agingassociated diseases. What do we know so far?, Cellular and Molecular Neurobiology 2008; 28 (5): 643-652.
Amagase H, Nance DM. Lycium barbarum increases caloric expenditure and decreases waist circumference in healthy overweight men and women: pilot study. Journal of the American College of Nutrition 2011; 30 (5): 304-309.
Hsu CH, Nance DM, Amagase H. A metaanalysis of clinical improvements of general wellbeing by a standardized Lycium barbarum. Journal of medicinal food 2012; 15 (11): 1006-1014.
Mocan A, Vlase L, Vodnar DC, Bischin C, Hanganu D, Gheldiu AM, Oprean R, Silaghi-Dumitrescu R, Crișan G. Polyphenolic content, antioxidant and antimicrobial activities of Lycium barbarum L. and Lycium chinense Mill. Leaves. Molecules 2014; 19 (7): 10056-10073.
Carnés J, de Larramendi CH, Ferrer A, Huertas AJ, López-Matas MA, Pagán JA, Navarro LA, García-Abujeta JL, Vicario S, Peña M. Recently introduced foods as new allergenic sources: sensitisation to Goji berries (Lycium barbarum), Food chemistry 2013; 137 (1): 130-135.
Ballarín SM, Lopez-Matas MA, Abad DS, Pérez-Cinto N, Carnés J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). Journal of Investigational Allergology and Clinical Immunology 2011; 21: 567-570.
Chua YT, Ang XL, Zhong XM, Khoo KS. Interaction between warfarin and Chinese herbal medicines. Singapore medical journal 2015; 56: 11-18.
Rivera CA, Ferro CL, Bursua AJ, Gerber BS. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 2012; 32: e50-e53.
Ulbricht C, Bryan JK, Costa D, Culwell S, Giese N, Isaac R, Nummy K, Pham T, Papp C, Rusie E. An evidencebased systematic review of Goji (Lycium spp.) by the Natural Standard Research Collaboration. Journal of dietary supplements 2015; 12: 184-240.
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