Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects

Hamed Khouja

doi:doi:10.11648/j.ijcm.20170101.12

| Peer-Reviewed

Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects

Hamed Khouja

Published in International Journal of Chinese Medicine (Volume 1, Issue 1)

Received: 15 January 2017 Accepted: 4 February 2017 Published: 22 February 2017

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Biological marker changes during pregnancy and adequate reference values are of importance for correct clinical decisions. There are only few studies on the variations of laboratory tests during normal pregnancies, especially during the first trimesters. The aim of this study was to assess the effects of pregnancy in the first trimester on several biochemical parameters in healthy pregnant women by comparing the values of these parameters with non-pregnant women. Blood samples were taken from 30healthy pregnant women and 30non-pregnant women. Glucose, Total protein (TP), Albumin, Total bilirubin (TB), Alkaline phosphatase (ALP), Aspartate transaminase(AST), Alanine transaminase(ALT), Gamma glutamyl transferase(GGT), Cortisol and Phosphatewere measured. the result shows that a pregnant affected in serum total bilirubin, Aspartate transaminase, Cortisol. It recorded a significance decrease in total bilirubin and Aspartate transaminase in pregnant women compared with non-pregnant women, While the pregnant caused significant increase in Cortisol compared with non-pregnant women.

Published in	International Journal of Chinese Medicine (Volume 1, Issue 1)
DOI	10.11648/j.ijcm.20170101.12
Page(s)	10-15
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pregnant, Biochemical Parameters, Aspartate Transaminase(AST), Alanine Transaminase(ALT), Gamma Glutamyltransferase (GGT), Cortisol

References

[1]	Torgersen, K. L. and Curran, C. A. (2006). A systematic approach to the physiologic adaptations of pregnancy. Crit. Care. Nurs. Q. 29 (1): 2-19.
[2]	Mattison, D. R, Blann, E. and Malek A. (1991). Physiological alterations during pregnancy: impact on toxicokinetics. Fundam. Appl. Toxicol.16 (2): 215-218.
[3]	Sibai, B. M. And Frangieh, A. (1995). Maternal adaptation to pregnancy. Curr. Opin. Obstet. Gynecol. 7 (6): 420-426.
[4]	Frederiksen, M. C. (2001). Physiologic changes in pregnancy and their effect on drug disposition. Semin. Perinatol. 25 (3): 120-123.
[5]	Costantine, M. M. (2014). Physiologic and pharmacokinetic changes in pregnancy. Front. Pharmacol. 3;5: 65.
[6]	Anday, E. K. and Cohen, A. (1990). Liver disease associated with pregnancy. Ann. Clin. Lab. Sci. 20 (4): 233-238.
[7]	Lata, I. (2013). Hepatobiliary diseases during pregnancy and their management: An update. Int. J. Crit. Illn. Inj. Sci. 3 (3): 175-182.
[8]	Mbassa, G. K. and Poulsen, J. S. (1991). Influence of pregnancy, lactation and environment on some clinical chemical reference values in Danish landrace dairy goats (Capra hircus) of different parity--I. Electrolytes and enzymes. Comp. Biochem. Physiol. B.;100 (2): 413-422.
[9]	Wójcicka-Jagodzińska, J.; Romejko, E.; Piekarski, P.; Czajkowski, K.; Smolarczyk, R. and Lipiński, T. (1998). Second trimester calcium-phosphorus-magnesium homeostasis in women with threatened preterm delivery. Int. J. Gynaecol. Obstet. 61 (2): 121-125.
[10]	Yokus, B. and Cakir, U. D. (2006) Seasonal and physiological variations in serum chemistry and mineral concentrations in cattle. Biol. Trace. Elem. Res.109 (3): 255-266.
[11]	Michałek, K.; Ozgo, M. and Skrzypczak, W. F. (2009). Renal regulation of calcium-phosphate metabolism in single- and twin pregnant goats. Folia Biol (Krakow).;57 (3-4): 199-205.
[12]	Knopp, R. H.; Bergelin, R. O.; Wahl, P. W.; Walden, C. E. and Chapman, M. B. (1985). Clinical chemistry alterations in pregnancy and oral contraceptive use. Obstet Gynecol. 66 (5): 682-690.
[13]	Järnfelt-Samsioe, A.; Eriksson, B.;Waldenström,J. and Samsioe, G. (1986). Serum bile acids, gamma-glutamyltransferase and routine liver function tests in emetic and nonemetic pregnancies. Gynecol. Obstet. Invest.; 21 (4): 169-176.
[14]	Bacq, Y.; Zarka, O.; Bréchot, J. F.; Mariotte, N.; Vol, S.; Tichet, J. and Weill, J. (1996). Liver function tests in normal pregnancy: a prospective study of 103 pregnant women and 103 matched controls. Hepatology. 23 (5): 1030-1034.
[15]	Lbdah, J. A. (2012). Maternal liver disease. liver in normal pregnancy.
[16]	Raińska-Giezek, T. (1995). Influence of caffeine on toxicity and pharmacokinetics of paracetamol. Ann. Acad. Med. Stetin.;41:69-85.
[17]	Sonntag, O. and Scholer, A. (2001). Drug interference in clinical chemistry: recommendation of drugs and their concentrations to be used in drug interference studies. Ann. Clin. Biochem. 38 (Pt 4): 376-385.
[18]	Ramírez-Farías, C.; Madrigal-Santillán, E.; Gutiérrez-Salinas, J.; Rodríguez-Sánchez, N.; Martínez-Cruz, M.; Valle-Jones, I.;Gramlich-Martínez, I.; Hernández-Ceruelos, A. and Morales-Gonzaléz, J. A. (2008). Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced by partial hepatectomy in rats. World. J. Gastroenterol. 14; 14 (6): 899-907.
[19]	Carter, J. (1990). Liver function in normal pregnancy. Aust. N. Z. J. Obstet. Gynaecol. 30 (4): 296-302.
[20]	Van Buul, E. J.; Steegers, E. A.; Jongsma, H. W.; Eskes, T. K.; Thomas, C. M. and Hein, P. R. (1995). Haematological and biochemical profile of uncomplicated pregnancy in nulliparous women; a longitudinal study. Neth. J. Med. 46 (2): 73-85.
[21]	Bar, J.; Hod, M.;Erman, A.; Kaplan, B.; Ovadia, J. and Schoenfeld, A. (1996). Microalbuminuria in early pregnancy in normal and high-risk patients. Early Pregnancy. 2 (3): 197-200.
[22]	Shrivastava, S.; Jadon, A. andShukla, S. (2007). Effect of tiron and its combination with nutritional supplements against vanadium intoxication in female albino rats. J. Toxicol. Sci. 32 (2): 185-192.
[23]	Sogabe, N.; Maruyama, R.; Hosori, T.; Goseki-Sone and M. (2007). Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats. J. Nutr. Sci. Vitaminol. (Tokyo). 53 (3): 219-224.
[24]	Obianime, A. W. and Roberts, II. (2009). Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male Wistar rats. Niger. J. Physiol. Sci. 24 (2): 177-185.
[25]	Haraikawa, M.; Sogabe, N.; Tanabe, R.; Hosoi, T. and Goseki-Sone, M. (2011). Vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) induces intestinal alkaline phosphatase gene expression. J. Nutr. Sci. Vitaminol. (Tokyo).; 57 (4): 274-279.
[26]	Honkanen, H.; Ranta, S.; Ylikorkala, O. andHeikinheimo, O. (2005). Effect of antiprogesterone mifepristone followed by misoprostol on circulating leptin in early pregnancy. Acta. Obstet. Gynecol. Scand. 84 (2): 134-139.
[27]	Moore, D. E.; Kawagoe, S.; Davajan, V.; Mishell, D. R. and Nakamura, R. M. (1978). An in vivo system in man for quantitation of estrogenicity. I. Physiologic changes in binding capacity of serum corticosteroid-binding globulin. Am. J. Obstet. Gynecol. 15;130 (4): 475-481.
[28]	Demey-Ponsart, E.; Foidart, J. M.; Sulon, J. and Sodoyez, J. C. (1982). Serum CBG, free and total cortisol and circadian patterns of adrenal function in normal pregnancy. J. Steroid. Biochem. 16 (2): 165-169.
[29]	Branch, D. W. (1992). Physiologic adaptations of pregnancy. Am J ReprodImmunol. 28 (3-4): 120-122.
[30]	Saenger, P. (1983). 6 beta-hydroxycortisol in random urine samples as an indicator of enzyme induction. ClinPharmacolTher. 1983 Dec; 34 (6): 818-821.
[31]	Ohkita, C. and Goto, M. (1990). Increased 6-hydroxycortisol excretion in pregnant women: implication of drug-metabolizing enzyme induction. DICP.24 (9): 814-816.
[32]	Hanan F A, Maha Z R, Dina M, MM, Desoky, NA I and Eman A Y. (2016). Therapeutic and protective effects of Caesalpinia gilliesii and Cajanus cajan proteins against acetaminophen overdose-induced renal damage. Toxicology and Industrial Health 2016, Vol. 32 (4) 753–768.
[33]	Fayez A B, Karem H, Mahmoud and Somaya M I. (2016) Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides
[34]	diazinon and profenfos. Toxicology and Industrial Health 2016, Vol. 32 (4) 666–676.

Cite This Article

Plain Text BibTeX RIS

APA Style

Hamed Khouja. (2017). Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects. International Journal of Chinese Medicine, 1(1), 10-15. https://doi.org/10.11648/j.ijcm.20170101.12

Copy | Download

ACS Style

Hamed Khouja. Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects. Int. J. Chin. Med. 2017, 1(1), 10-15. doi: 10.11648/j.ijcm.20170101.12

Copy | Download

AMA Style

Hamed Khouja. Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects. Int J Chin Med. 2017;1(1):10-15. doi: 10.11648/j.ijcm.20170101.12

Copy | Download

@article{10.11648/j.ijcm.20170101.12,
  author = {Hamed Khouja},
  title = {Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects},
  journal = {International Journal of Chinese Medicine},
  volume = {1},
  number = {1},
  pages = {10-15},
  doi = {10.11648/j.ijcm.20170101.12},
  url = {https://doi.org/10.11648/j.ijcm.20170101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20170101.12},
  abstract = {Biological marker changes during pregnancy and adequate reference values are of importance for correct clinical decisions. There are only few studies on the variations of laboratory tests during normal pregnancies, especially during the first trimesters. The aim of this study was to assess the effects of pregnancy in the first trimester on several biochemical parameters in healthy pregnant women by comparing the values of these parameters with non-pregnant women. Blood samples were taken from 30healthy pregnant women and 30non-pregnant women. Glucose, Total protein (TP), Albumin, Total bilirubin (TB), Alkaline phosphatase (ALP), Aspartate transaminase(AST), Alanine transaminase(ALT), Gamma glutamyl transferase(GGT), Cortisol and Phosphatewere measured. the result shows that a pregnant affected in serum total bilirubin, Aspartate transaminase, Cortisol. It recorded a significance decrease in total bilirubin and Aspartate transaminase in pregnant women compared with non-pregnant women, While the pregnant caused significant increase in Cortisol compared with non-pregnant women.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects
AU  - Hamed Khouja
Y1  - 2017/02/22
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcm.20170101.12
DO  - 10.11648/j.ijcm.20170101.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 10
EP  - 15
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20170101.12
AB  - Biological marker changes during pregnancy and adequate reference values are of importance for correct clinical decisions. There are only few studies on the variations of laboratory tests during normal pregnancies, especially during the first trimesters. The aim of this study was to assess the effects of pregnancy in the first trimester on several biochemical parameters in healthy pregnant women by comparing the values of these parameters with non-pregnant women. Blood samples were taken from 30healthy pregnant women and 30non-pregnant women. Glucose, Total protein (TP), Albumin, Total bilirubin (TB), Alkaline phosphatase (ALP), Aspartate transaminase(AST), Alanine transaminase(ALT), Gamma glutamyl transferase(GGT), Cortisol and Phosphatewere measured. the result shows that a pregnant affected in serum total bilirubin, Aspartate transaminase, Cortisol. It recorded a significance decrease in total bilirubin and Aspartate transaminase in pregnant women compared with non-pregnant women, While the pregnant caused significant increase in Cortisol compared with non-pregnant women.
VL  - 1
IS  - 1
ER  -

Copy | Download

Author Information

Hamed Khouja

Department of Medical Technology Sciences, King Abdul Aziz University, Jeddah, Saudi Arabia

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Hamed Khouja. (2017). Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects. International Journal of Chinese Medicine, 1(1), 10-15. https://doi.org/10.11648/j.ijcm.20170101.12

Copy | Download

ACS Style

Hamed Khouja. Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects. Int. J. Chin. Med. 2017, 1(1), 10-15. doi: 10.11648/j.ijcm.20170101.12

Copy | Download

AMA Style

Hamed Khouja. Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects. Int J Chin Med. 2017;1(1):10-15. doi: 10.11648/j.ijcm.20170101.12

Copy | Download

@article{10.11648/j.ijcm.20170101.12,
  author = {Hamed Khouja},
  title = {Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects},
  journal = {International Journal of Chinese Medicine},
  volume = {1},
  number = {1},
  pages = {10-15},
  doi = {10.11648/j.ijcm.20170101.12},
  url = {https://doi.org/10.11648/j.ijcm.20170101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20170101.12},
  abstract = {Biological marker changes during pregnancy and adequate reference values are of importance for correct clinical decisions. There are only few studies on the variations of laboratory tests during normal pregnancies, especially during the first trimesters. The aim of this study was to assess the effects of pregnancy in the first trimester on several biochemical parameters in healthy pregnant women by comparing the values of these parameters with non-pregnant women. Blood samples were taken from 30healthy pregnant women and 30non-pregnant women. Glucose, Total protein (TP), Albumin, Total bilirubin (TB), Alkaline phosphatase (ALP), Aspartate transaminase(AST), Alanine transaminase(ALT), Gamma glutamyl transferase(GGT), Cortisol and Phosphatewere measured. the result shows that a pregnant affected in serum total bilirubin, Aspartate transaminase, Cortisol. It recorded a significance decrease in total bilirubin and Aspartate transaminase in pregnant women compared with non-pregnant women, While the pregnant caused significant increase in Cortisol compared with non-pregnant women.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Effects of Pregnanton Some Biochemical Parameters in Healthy Subjects
AU  - Hamed Khouja
Y1  - 2017/02/22
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcm.20170101.12
DO  - 10.11648/j.ijcm.20170101.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 10
EP  - 15
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20170101.12
AB  - Biological marker changes during pregnancy and adequate reference values are of importance for correct clinical decisions. There are only few studies on the variations of laboratory tests during normal pregnancies, especially during the first trimesters. The aim of this study was to assess the effects of pregnancy in the first trimester on several biochemical parameters in healthy pregnant women by comparing the values of these parameters with non-pregnant women. Blood samples were taken from 30healthy pregnant women and 30non-pregnant women. Glucose, Total protein (TP), Albumin, Total bilirubin (TB), Alkaline phosphatase (ALP), Aspartate transaminase(AST), Alanine transaminase(ALT), Gamma glutamyl transferase(GGT), Cortisol and Phosphatewere measured. the result shows that a pregnant affected in serum total bilirubin, Aspartate transaminase, Cortisol. It recorded a significance decrease in total bilirubin and Aspartate transaminase in pregnant women compared with non-pregnant women, While the pregnant caused significant increase in Cortisol compared with non-pregnant women.
VL  - 1
IS  - 1
ER  -

Copy | Download