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25-Hydroxyvitamin D3 Deficiency and Dyslipidemia in Type 2 Diabetic Subjects
International Journal of Chinese Medicine
Volume 1, Issue 3, July 2017, Pages: 108-112
Received: Feb. 12, 2017; Accepted: Apr. 13, 2017; Published: Jul. 11, 2017
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Authors
Azhar Memon, Department of Medicine, Isra University, Hyderabad, Pakistan
Muhammad Atif Ata, Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan
Shumaila Shaikh, Department of Biochemistry, Khairpur Medical College, Khairpur, Pakistan
Haji Khan Khoharo, Department of Medicine, Isra University, Hyderabad, Pakistan
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Abstract
The present Observational study was conducted to estimate the 25-hydroxyvitamin D3 deficiency and its association with dyslipidemia in type 2 Diabetes mellitus subjects at the Department of Medicine, Isra University Hospital and Consultant Clinics Hyderabad from January 2014 to July 2014. A sample of 310 diagnosed type 2 DM were selected through non-probability purposive sampling according to inclusion and exclusion criteria. Serum 25-OH-D3 was estimated by ARCHITECT I 1000 system. Lipids sub fractions were analyzed according to standard methods. Data was analyzed on SPSS version 21.0. Data was analyzed on SPSS version 21.0. Continuous and categorical variables were analyzed by student’s t test and chi square test respectively. The associations of various lipid fractions with vitamin D3 were analyzed by Pearson’s correlation. The significant p-value was taken at ≤ 0.05. Reduced 25-hydroxyvitamin D3 levels were observed in 84.1% (n = 261). The 25-hydroxyvitamin D3 levels as low as 6ng/dl was observed in present study. The lipid profile status of subjects with normal and reduced 25-hydroxyvitamin D3 showed significant differences (p = 0.001). Triglycerides, LDLc, VLDLc, and Cholesterols exhibited an inverse correlation with 25 hydroxyvitamin D3; however a positive correlation was noted for HDL cholesterol. In conclusion, the vitamin D3 deficiency was observed in type 2 diabetic subject and showed independent association with dyslipidemia in type 2 diabetics.
Keywords
25-Hydroxyvitamin D3, Dyslipidemia, Diabetes Mellitus, Sindh
To cite this article
Azhar Memon, Muhammad Atif Ata, Shumaila Shaikh, Haji Khan Khoharo, 25-Hydroxyvitamin D3 Deficiency and Dyslipidemia in Type 2 Diabetic Subjects, International Journal of Chinese Medicine. Vol. 1, No. 3, 2017, pp. 108-112. doi: 10.11648/j.ijcm.20170103.16
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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