Attenuating the Post-Stroke Epilepsy Using the Si-Miao-Yong-An Decoction for Treatment
International Journal of Chinese Medicine
Volume 4, Issue 3, September 2020, Pages: 54-60
Received: Jul. 7, 2020; Accepted: Jul. 27, 2020; Published: Aug. 20, 2020
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Authors
Shisheng Jiang, Institute of Clinical Research, Hunan Academy of Traditional Chinese Medicine, Changsha, China
Mukut Sharma, Renal Research Laboratory, and the Midwest Veterans’ Biomedical Research Foundation (MVBRF), VA Medical Center, Kansas City, USA
Yuming Han, Institute of Clinical Research, Hunan Academy of Traditional Chinese Medicine, Changsha, China
Hongmei Wang, Institute of Clinical Research, Hunan Academy of Traditional Chinese Medicine, Changsha, China
Feizhou He, Shuangteng Rehabilitation Hospital of TCM, Loudi, China
Shuangteng He, Institute of Clinical Research, Hunan Academy of Traditional Chinese Medicine, Changsha, China; Shuangteng Rehabilitation Hospital of TCM, Loudi, China; Stroke Research Laboratory, VA Medical Center, Kansas City, USA
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Abstract
Objective: To observe the clinical efficacy of Si-Miao-Yong-An decoction (SMYAD) in the treatment of post-stroke epilepsy. Methods: 112 patients with post-stroke epilepsy were randomly assigned to either the control or the treatment group (56 subjects in each group). Patients in the control group received oral levetiracetam (LEV) combined with other conventional Western medicine treatment (s), while the treatment group received SMYAD only. Outcome measures were the duration for seizure remission, remission rates at one year, changes in electroencephalogram (EEG), scores of National Institutes of Health Stroke Scale (NIHSS), and adverse events in the two groups. Results: The numbers of patients who completed treatment were 41 and 55 in the LEV group and SMYAD group, respectively (P<0.01). After 12 months of treatment, epilepsy was controlled in 35 patients in LEV group and 47 in SMYAD group (P=0.990). Seizure remission was achieved in 15.1 days in LEV group and 8.7 days in SMYAD group (P<0.01). Relapse of epilepsy was observed in 19 cases in the LEV group and 11 in SMYAD group (P<0.01). Abnormal EEG patterns persisted in 32 patients in LEV group and 29 patients in SMYAD group (P<0.01). The NIHSS score decreased from 12.2 to 9.4 in LEV group, and from 12.5 to 5.8 in SMYAD group (P<0.01). Adverse effects of treatment were observed in 28 cases in LEV group and 6 patients in SMYAD group (P<0.01). The most common adverse events reported were rash, fatigue, somnolence, headache, and dizziness in LEV group, and diarrhea in SMYAD group. Adverse effects caused withdrawal of 8 patients from LEV group but none from SMYAD group (P<0.01). Conclusion: SMYAD is an effective and well tolerated remedy for post-stroke epilepsy. Further large scale randomized controlled trials are needed to establish the efficacy and tolerability.
Keywords
Post-Stroke Epilepsy, Traditional Chinese Medicine Treatment, Si-Miao-Yong-An Decoction
To cite this article
Shisheng Jiang, Mukut Sharma, Yuming Han, Hongmei Wang, Feizhou He, Shuangteng He, Attenuating the Post-Stroke Epilepsy Using the Si-Miao-Yong-An Decoction for Treatment, International Journal of Chinese Medicine. Vol. 4, No. 3, 2020, pp. 54-60. doi: 10.11648/j.ijcm.20200403.12
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Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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