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International Journal of Chinese Medicine

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Attenuating the Post-Stroke Epilepsy Using the Si-Miao-Yong-An Decoction for Treatment

Shisheng Jiang, Mukut Sharma, Yuming Han, Hongmei Wang, Feizhou He, Shuangteng He
Received: 7 July 2020    Accepted: 27 July 2020    Published: 20 August 2020
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Abstract

Objective: To observe the clinical efficacy of Si-Miao-Yong-An decoction (SMYAD) in the treatment of post-stroke epilepsy. Methods: 112 patients with post-stroke epilepsy were randomly assigned to either the control or the treatment group (56 subjects in each group). Patients in the control group received oral levetiracetam (LEV) combined with other conventional Western medicine treatment (s), while the treatment group received SMYAD only. Outcome measures were the duration for seizure remission, remission rates at one year, changes in electroencephalogram (EEG), scores of National Institutes of Health Stroke Scale (NIHSS), and adverse events in the two groups. Results: The numbers of patients who completed treatment were 41 and 55 in the LEV group and SMYAD group, respectively (P<0.01). After 12 months of treatment, epilepsy was controlled in 35 patients in LEV group and 47 in SMYAD group (P=0.990). Seizure remission was achieved in 15.1 days in LEV group and 8.7 days in SMYAD group (P<0.01). Relapse of epilepsy was observed in 19 cases in the LEV group and 11 in SMYAD group (P<0.01). Abnormal EEG patterns persisted in 32 patients in LEV group and 29 patients in SMYAD group (P<0.01). The NIHSS score decreased from 12.2 to 9.4 in LEV group, and from 12.5 to 5.8 in SMYAD group (P<0.01). Adverse effects of treatment were observed in 28 cases in LEV group and 6 patients in SMYAD group (P<0.01). The most common adverse events reported were rash, fatigue, somnolence, headache, and dizziness in LEV group, and diarrhea in SMYAD group. Adverse effects caused withdrawal of 8 patients from LEV group but none from SMYAD group (P<0.01). Conclusion: SMYAD is an effective and well tolerated remedy for post-stroke epilepsy. Further large scale randomized controlled trials are needed to establish the efficacy and tolerability.

DOI 10.11648/j.ijcm.20200403.12
Published in International Journal of Chinese Medicine (Volume 4, Issue 3, September 2020)
Page(s) 54-60
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

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Keywords

Post-Stroke Epilepsy, Traditional Chinese Medicine Treatment, Si-Miao-Yong-An Decoction

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    Shisheng Jiang, Mukut Sharma, Yuming Han, Hongmei Wang, Feizhou He, et al. (2020). Attenuating the Post-Stroke Epilepsy Using the Si-Miao-Yong-An Decoction for Treatment. International Journal of Chinese Medicine, 4(3), 54-60. https://doi.org/10.11648/j.ijcm.20200403.12

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    ACS Style

    Shisheng Jiang; Mukut Sharma; Yuming Han; Hongmei Wang; Feizhou He, et al. Attenuating the Post-Stroke Epilepsy Using the Si-Miao-Yong-An Decoction for Treatment. Int. J. Chin. Med. 2020, 4(3), 54-60. doi: 10.11648/j.ijcm.20200403.12

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    AMA Style

    Shisheng Jiang, Mukut Sharma, Yuming Han, Hongmei Wang, Feizhou He, et al. Attenuating the Post-Stroke Epilepsy Using the Si-Miao-Yong-An Decoction for Treatment. Int J Chin Med. 2020;4(3):54-60. doi: 10.11648/j.ijcm.20200403.12

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  • @article{10.11648/j.ijcm.20200403.12,
  author = {Shisheng Jiang and Mukut Sharma and Yuming Han and Hongmei Wang and Feizhou He and Shuangteng He},
  title = {Attenuating the Post-Stroke Epilepsy Using the Si-Miao-Yong-An Decoction for Treatment},
  journal = {International Journal of Chinese Medicine},
  volume = {4},
  number = {3},
  pages = {54-60},
  doi = {10.11648/j.ijcm.20200403.12},
  url = {https://doi.org/10.11648/j.ijcm.20200403.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20200403.12},
  abstract = {Objective: To observe the clinical efficacy of Si-Miao-Yong-An decoction (SMYAD) in the treatment of post-stroke epilepsy. Methods: 112 patients with post-stroke epilepsy were randomly assigned to either the control or the treatment group (56 subjects in each group). Patients in the control group received oral levetiracetam (LEV) combined with other conventional Western medicine treatment (s), while the treatment group received SMYAD only. Outcome measures were the duration for seizure remission, remission rates at one year, changes in electroencephalogram (EEG), scores of National Institutes of Health Stroke Scale (NIHSS), and adverse events in the two groups. Results: The numbers of patients who completed treatment were 41 and 55 in the LEV group and SMYAD group, respectively (PP=0.990). Seizure remission was achieved in 15.1 days in LEV group and 8.7 days in SMYAD group (PPPPPP<0.01). Conclusion: SMYAD is an effective and well tolerated remedy for post-stroke epilepsy. Further large scale randomized controlled trials are needed to establish the efficacy and tolerability.},
 year = {2020}
}

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  • TY  - JOUR
T1  - Attenuating the Post-Stroke Epilepsy Using the Si-Miao-Yong-An Decoction for Treatment
AU  - Shisheng Jiang
AU  - Mukut Sharma
AU  - Yuming Han
AU  - Hongmei Wang
AU  - Feizhou He
AU  - Shuangteng He
Y1  - 2020/08/20
PY  - 2020
N1  - https://doi.org/10.11648/j.ijcm.20200403.12
DO  - 10.11648/j.ijcm.20200403.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 54
EP  - 60
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20200403.12
AB  - Objective: To observe the clinical efficacy of Si-Miao-Yong-An decoction (SMYAD) in the treatment of post-stroke epilepsy. Methods: 112 patients with post-stroke epilepsy were randomly assigned to either the control or the treatment group (56 subjects in each group). Patients in the control group received oral levetiracetam (LEV) combined with other conventional Western medicine treatment (s), while the treatment group received SMYAD only. Outcome measures were the duration for seizure remission, remission rates at one year, changes in electroencephalogram (EEG), scores of National Institutes of Health Stroke Scale (NIHSS), and adverse events in the two groups. Results: The numbers of patients who completed treatment were 41 and 55 in the LEV group and SMYAD group, respectively (PP=0.990). Seizure remission was achieved in 15.1 days in LEV group and 8.7 days in SMYAD group (PPPPPP<0.01). Conclusion: SMYAD is an effective and well tolerated remedy for post-stroke epilepsy. Further large scale randomized controlled trials are needed to establish the efficacy and tolerability.
VL  - 4
IS  - 3
ER  -

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Author Information

  • Shisheng Jiang

    Institute of Clinical Research, Hunan Academy of Traditional Chinese Medicine, Changsha, China

  • Mukut Sharma

    Renal Research Laboratory, and the Midwest Veterans’ Biomedical Research Foundation (MVBRF), VA Medical Center, Kansas City, USA

  • Yuming Han

    Institute of Clinical Research, Hunan Academy of Traditional Chinese Medicine, Changsha, China

  • Hongmei Wang

    Institute of Clinical Research, Hunan Academy of Traditional Chinese Medicine, Changsha, China

  • Feizhou He

    Shuangteng Rehabilitation Hospital of TCM, Loudi, China

  • Shuangteng He

    Institute of Clinical Research, Hunan Academy of Traditional Chinese Medicine, Changsha, China; Shuangteng Rehabilitation Hospital of TCM, Loudi, China; Stroke Research Laboratory, VA Medical Center, Kansas City, USA

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