Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update)
Journal of Chemical, Environmental and Biological Engineering
Volume 4, Issue 1, June 2020, Pages: 1-10
Received: Feb. 3, 2020; Accepted: Feb. 24, 2020; Published: May 11, 2020
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Manideep Chowdary Pachva, Department of Molecular Genetics, Bangor University, Bangor, United Kingdom
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Systemic lupus erythematosus (SLE) is a multisystem inflammatory and autoimmune disorder that usually affects various self-tissues of the body, whose sera is predominantly reported to have autoantibodies against Ro60 or TROVE-2 protein. Ro60 is a ring-shaped RNA-binding protein, that usually binds misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (hY-RNAs). Y RNAs are known to be involved in regulating cellular stress responses and also in initiation of chromosomal replication. Ro60 is known to have 6 isoforms along with the short isoform. Recent studies of Ro60 protein in mammalian cells suggests that Ro60 is vital for the cell survival after the UV irradiation. It is evident that Ro60 is essential for degrading the damaged RNA due to the UV irradiation, because exposure to the UV irradiation might result in RNA: RNA and RNA: Protein crosslinks. Also, role of Ro60 in maintaining the tolerance is supported by the experiment which resulted in development of lupus like syndrome in the Ro60 knock-down mice by producing antibodies against chromatin and ribosomes. Thus, it is evident from the various studies that Ro60 is inevitably important for the cells and tissues for preventing the autoimmunity. This review focusses on the pathology and autoantibody system in SLE, structure and functions of the Ro60 in association with Y RNAs, and epitope bindings of Ro60 to the anti-Ro positive sera from SLE patients.
Self-tolerance, Systemic Lupus Erythematosus, Ro60 Protein, Y RNAs, Anti-Ro Autoantibodies
To cite this article
Manideep Chowdary Pachva, Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update), Journal of Chemical, Environmental and Biological Engineering. Vol. 4, No. 1, 2020, pp. 1-10. doi: 10.11648/j.jcebe.20200401.11
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