Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats

Omowumi Oyeronke Adewale; Ekundayo Stephen Samuel; Opeyemi Olusayo Oluwuyi; Seun Funmilola Akomolafe

doi:doi:10.11648/j.jcebe.20180201.16

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Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats

Omowumi Oyeronke Adewale, Ekundayo Stephen Samuel, Opeyemi Olusayo Oluwuyi, Seun Funmilola Akomolafe

Published in Journal of Chemical, Environmental and Biological Engineering (Volume 2, Issue 1)

Received: 5 July 2018 Accepted: 27 July 2018 Published: 27 August 2018

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Abstract

Study aim: More is still to be known about the combinative effect of lead and arsenic compounds on critical organs. In this study, the effect of single and combined exposure to lead and arsenic on some biomarkers associated with liver and kidney functions in healthy Wistar rats was assessed. Method: The rats were divided into four groups (n = 5) and were treated with sodium arsenite or lead acetate individually or in combination for 14 days. Results: The results revealed that single exposure to either compound caused significant increase in the hepatic transaminases and alkaline phosphatase. Significant decrease in serum proteins and glucose concentration were also observed with morphological changes in the liver of treated rats as discovered by the photomicrographs from light microscopy indicating hepatotoxicity. Similarly, significant increase in the blood urea nitrogen (BUN) and creatinine concentration with simultaneous rise in the concentrations of serum potassium and sodium were observed. The photomicrographs of the kidney from light microscopy showed congestion in the interstitial spaces indicating compromised function of the kidney. The combination of the two metals demonstrated the enhanced effect on these parameters when likened with their individual treatments. Conclusion: This study therefore proves the enhanced toxicity induced by co-exposure to lead acetate and sodium arsenite among biomarkers of liver and kidney functions in Wistar rats.

Published in	Journal of Chemical, Environmental and Biological Engineering (Volume 2, Issue 1)
DOI	10.11648/j.jcebe.20180201.16
Page(s)	32-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Lead Acetate, Sodium Arsenite, Liver Biomarkers, Kidney Biomarkers, Histopathology and Toxicity

References

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Omowumi Oyeronke Adewale, Ekundayo Stephen Samuel, Opeyemi Olusayo Oluwuyi, Seun Funmilola Akomolafe. (2018). Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats. Journal of Chemical, Environmental and Biological Engineering, 2(1), 32-39. https://doi.org/10.11648/j.jcebe.20180201.16

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ACS Style

Omowumi Oyeronke Adewale; Ekundayo Stephen Samuel; Opeyemi Olusayo Oluwuyi; Seun Funmilola Akomolafe. Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats. J. Chem. Environ. Biol. Eng. 2018, 2(1), 32-39. doi: 10.11648/j.jcebe.20180201.16

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AMA Style

Omowumi Oyeronke Adewale, Ekundayo Stephen Samuel, Opeyemi Olusayo Oluwuyi, Seun Funmilola Akomolafe. Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats. J Chem Environ Biol Eng. 2018;2(1):32-39. doi: 10.11648/j.jcebe.20180201.16

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@article{10.11648/j.jcebe.20180201.16,
  author = {Omowumi Oyeronke Adewale and Ekundayo Stephen Samuel and Opeyemi Olusayo Oluwuyi and Seun Funmilola Akomolafe},
  title = {Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats},
  journal = {Journal of Chemical, Environmental and Biological Engineering},
  volume = {2},
  number = {1},
  pages = {32-39},
  doi = {10.11648/j.jcebe.20180201.16},
  url = {https://doi.org/10.11648/j.jcebe.20180201.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jcebe.20180201.16},
  abstract = {Study aim: More is still to be known about the combinative effect of lead and arsenic compounds on critical organs. In this study, the effect of single and combined exposure to lead and arsenic on some biomarkers associated with liver and kidney functions in healthy Wistar rats was assessed. Method: The rats were divided into four groups (n = 5) and were treated with sodium arsenite or lead acetate individually or in combination for 14 days. Results: The results revealed that single exposure to either compound caused significant increase in the hepatic transaminases and alkaline phosphatase. Significant decrease in serum proteins and glucose concentration were also observed with morphological changes in the liver of treated rats as discovered by the photomicrographs from light microscopy indicating hepatotoxicity. Similarly, significant increase in the blood urea nitrogen (BUN) and creatinine concentration with simultaneous rise in the concentrations of serum potassium and sodium were observed. The photomicrographs of the kidney from light microscopy showed congestion in the interstitial spaces indicating compromised function of the kidney. The combination of the two metals demonstrated the enhanced effect on these parameters when likened with their individual treatments. Conclusion: This study therefore proves the enhanced toxicity induced by co-exposure to lead acetate and sodium arsenite among biomarkers of liver and kidney functions in Wistar rats.},
 year = {2018}
}

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TY  - JOUR
T1  - Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats
AU  - Omowumi Oyeronke Adewale
AU  - Ekundayo Stephen Samuel
AU  - Opeyemi Olusayo Oluwuyi
AU  - Seun Funmilola Akomolafe
Y1  - 2018/08/27
PY  - 2018
N1  - https://doi.org/10.11648/j.jcebe.20180201.16
DO  - 10.11648/j.jcebe.20180201.16
T2  - Journal of Chemical, Environmental and Biological Engineering
JF  - Journal of Chemical, Environmental and Biological Engineering
JO  - Journal of Chemical, Environmental and Biological Engineering
SP  - 32
EP  - 39
PB  - Science Publishing Group
SN  - 2640-267X
UR  - https://doi.org/10.11648/j.jcebe.20180201.16
AB  - Study aim: More is still to be known about the combinative effect of lead and arsenic compounds on critical organs. In this study, the effect of single and combined exposure to lead and arsenic on some biomarkers associated with liver and kidney functions in healthy Wistar rats was assessed. Method: The rats were divided into four groups (n = 5) and were treated with sodium arsenite or lead acetate individually or in combination for 14 days. Results: The results revealed that single exposure to either compound caused significant increase in the hepatic transaminases and alkaline phosphatase. Significant decrease in serum proteins and glucose concentration were also observed with morphological changes in the liver of treated rats as discovered by the photomicrographs from light microscopy indicating hepatotoxicity. Similarly, significant increase in the blood urea nitrogen (BUN) and creatinine concentration with simultaneous rise in the concentrations of serum potassium and sodium were observed. The photomicrographs of the kidney from light microscopy showed congestion in the interstitial spaces indicating compromised function of the kidney. The combination of the two metals demonstrated the enhanced effect on these parameters when likened with their individual treatments. Conclusion: This study therefore proves the enhanced toxicity induced by co-exposure to lead acetate and sodium arsenite among biomarkers of liver and kidney functions in Wistar rats.
VL  - 2
IS  - 1
ER  -

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Author Information

Omowumi Oyeronke Adewale

Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria
Ekundayo Stephen Samuel

Cancer Research and Molecular Biology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Opeyemi Olusayo Oluwuyi

Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria
Seun Funmilola Akomolafe

Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria

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Omowumi Oyeronke Adewale, Ekundayo Stephen Samuel, Opeyemi Olusayo Oluwuyi, Seun Funmilola Akomolafe. (2018). Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats. Journal of Chemical, Environmental and Biological Engineering, 2(1), 32-39. https://doi.org/10.11648/j.jcebe.20180201.16

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ACS Style

Omowumi Oyeronke Adewale; Ekundayo Stephen Samuel; Opeyemi Olusayo Oluwuyi; Seun Funmilola Akomolafe. Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats. J. Chem. Environ. Biol. Eng. 2018, 2(1), 32-39. doi: 10.11648/j.jcebe.20180201.16

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AMA Style

Omowumi Oyeronke Adewale, Ekundayo Stephen Samuel, Opeyemi Olusayo Oluwuyi, Seun Funmilola Akomolafe. Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats. J Chem Environ Biol Eng. 2018;2(1):32-39. doi: 10.11648/j.jcebe.20180201.16

Copy | Download

@article{10.11648/j.jcebe.20180201.16,
  author = {Omowumi Oyeronke Adewale and Ekundayo Stephen Samuel and Opeyemi Olusayo Oluwuyi and Seun Funmilola Akomolafe},
  title = {Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats},
  journal = {Journal of Chemical, Environmental and Biological Engineering},
  volume = {2},
  number = {1},
  pages = {32-39},
  doi = {10.11648/j.jcebe.20180201.16},
  url = {https://doi.org/10.11648/j.jcebe.20180201.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jcebe.20180201.16},
  abstract = {Study aim: More is still to be known about the combinative effect of lead and arsenic compounds on critical organs. In this study, the effect of single and combined exposure to lead and arsenic on some biomarkers associated with liver and kidney functions in healthy Wistar rats was assessed. Method: The rats were divided into four groups (n = 5) and were treated with sodium arsenite or lead acetate individually or in combination for 14 days. Results: The results revealed that single exposure to either compound caused significant increase in the hepatic transaminases and alkaline phosphatase. Significant decrease in serum proteins and glucose concentration were also observed with morphological changes in the liver of treated rats as discovered by the photomicrographs from light microscopy indicating hepatotoxicity. Similarly, significant increase in the blood urea nitrogen (BUN) and creatinine concentration with simultaneous rise in the concentrations of serum potassium and sodium were observed. The photomicrographs of the kidney from light microscopy showed congestion in the interstitial spaces indicating compromised function of the kidney. The combination of the two metals demonstrated the enhanced effect on these parameters when likened with their individual treatments. Conclusion: This study therefore proves the enhanced toxicity induced by co-exposure to lead acetate and sodium arsenite among biomarkers of liver and kidney functions in Wistar rats.},
 year = {2018}
}

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TY  - JOUR
T1  - Co-exposure of Lead Acetate and Sodium Arsenite Causes Alteration in the Markers of Liver and Kidney Functions in Male Wistar Rats
AU  - Omowumi Oyeronke Adewale
AU  - Ekundayo Stephen Samuel
AU  - Opeyemi Olusayo Oluwuyi
AU  - Seun Funmilola Akomolafe
Y1  - 2018/08/27
PY  - 2018
N1  - https://doi.org/10.11648/j.jcebe.20180201.16
DO  - 10.11648/j.jcebe.20180201.16
T2  - Journal of Chemical, Environmental and Biological Engineering
JF  - Journal of Chemical, Environmental and Biological Engineering
JO  - Journal of Chemical, Environmental and Biological Engineering
SP  - 32
EP  - 39
PB  - Science Publishing Group
SN  - 2640-267X
UR  - https://doi.org/10.11648/j.jcebe.20180201.16
AB  - Study aim: More is still to be known about the combinative effect of lead and arsenic compounds on critical organs. In this study, the effect of single and combined exposure to lead and arsenic on some biomarkers associated with liver and kidney functions in healthy Wistar rats was assessed. Method: The rats were divided into four groups (n = 5) and were treated with sodium arsenite or lead acetate individually or in combination for 14 days. Results: The results revealed that single exposure to either compound caused significant increase in the hepatic transaminases and alkaline phosphatase. Significant decrease in serum proteins and glucose concentration were also observed with morphological changes in the liver of treated rats as discovered by the photomicrographs from light microscopy indicating hepatotoxicity. Similarly, significant increase in the blood urea nitrogen (BUN) and creatinine concentration with simultaneous rise in the concentrations of serum potassium and sodium were observed. The photomicrographs of the kidney from light microscopy showed congestion in the interstitial spaces indicating compromised function of the kidney. The combination of the two metals demonstrated the enhanced effect on these parameters when likened with their individual treatments. Conclusion: This study therefore proves the enhanced toxicity induced by co-exposure to lead acetate and sodium arsenite among biomarkers of liver and kidney functions in Wistar rats.
VL  - 2
IS  - 1
ER  -

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