Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome

Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Samba Ngano Odette; Mouelle Sone; Ongolo Zogo Pierre; Dong à Zok Faustin; Yomi Jean; Juimo Alain George; Nko’o Amvene Samuel; Tiedeu Alain Bertin; Gonsu Fotsin Joseph

doi:doi:10.11648/j.ns.20160101.12

Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome

Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mouelle Sone, Ongolo Zogo Pierre, Dong à Zok Faustin, Yomi Jean, Juimo Alain George, Nko’o Amvene Samuel, Tiedeu Alain Bertin, Gonsu Fotsin Joseph

Published in Nuclear Science (Volume 1, Issue 1)

Received: 24 October 2016 Accepted: 23 November 2016 Published: 27 December 2016

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Abstract

Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7^th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.

Published in	Nuclear Science (Volume 1, Issue 1)
DOI	10.11648/j.ns.20160101.12
Page(s)	6-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Irradiation, Radiation Syndrome, Prodromal Phase, AGE, Rats

References

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Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mouelle Sone, et al. (2016). Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nuclear Science, 1(1), 6-17. https://doi.org/10.11648/j.ns.20160101.12

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Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Samba Ngano Odette; Mouelle Sone, et al. Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nucl. Sci. 2016, 1(1), 6-17. doi: 10.11648/j.ns.20160101.12

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AMA Style

Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mouelle Sone, et al. Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nucl Sci. 2016;1(1):6-17. doi: 10.11648/j.ns.20160101.12

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@article{10.11648/j.ns.20160101.12,
  author = {Kouam Foubi Brice Bertrand and Chuisseu Djamen Dieudonné Pascal and Dzeufiet Djomeni Paul Désiré and Samba Ngano Odette and Mouelle Sone and Ongolo Zogo Pierre and Dong à Zok Faustin and Yomi Jean and Juimo Alain George and Nko’o Amvene Samuel and Tiedeu Alain Bertin and Gonsu Fotsin Joseph},
  title = {Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome},
  journal = {Nuclear Science},
  volume = {1},
  number = {1},
  pages = {6-17},
  doi = {10.11648/j.ns.20160101.12},
  url = {https://doi.org/10.11648/j.ns.20160101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ns.20160101.12},
  abstract = {Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.},
 year = {2016}
}

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TY  - JOUR
T1  - Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome
AU  - Kouam Foubi Brice Bertrand
AU  - Chuisseu Djamen Dieudonné Pascal
AU  - Dzeufiet Djomeni Paul Désiré
AU  - Samba Ngano Odette
AU  - Mouelle Sone
AU  - Ongolo Zogo Pierre
AU  - Dong à Zok Faustin
AU  - Yomi Jean
AU  - Juimo Alain George
AU  - Nko’o Amvene Samuel
AU  - Tiedeu Alain Bertin
AU  - Gonsu Fotsin Joseph
Y1  - 2016/12/27
PY  - 2016
N1  - https://doi.org/10.11648/j.ns.20160101.12
DO  - 10.11648/j.ns.20160101.12
T2  - Nuclear Science
JF  - Nuclear Science
JO  - Nuclear Science
SP  - 6
EP  - 17
PB  - Science Publishing Group
SN  - 2640-4346
UR  - https://doi.org/10.11648/j.ns.20160101.12
AB  - Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.
VL  - 1
IS  - 1
ER  -

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Author Information

Kouam Foubi Brice Bertrand

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Chuisseu Djamen Dieudonné Pascal

Faculty of Health Sciences, Université des Montagnes, Bangangté, Bangangté, Cameroon
Dzeufiet Djomeni Paul Désiré

Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon
Samba Ngano Odette

Faculty of Sciences, University of Dschang, Dschang, Cameroon
Mouelle Sone

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Ongolo Zogo Pierre

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Dong à Zok Faustin

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Yomi Jean

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Juimo Alain George

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Nko’o Amvene Samuel

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Tiedeu Alain Bertin

National Advanced School of Engineering, University of Yaoundé I, Yaoundé, Cameroon
Gonsu Fotsin Joseph

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

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APA Style

Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mouelle Sone, et al. (2016). Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nuclear Science, 1(1), 6-17. https://doi.org/10.11648/j.ns.20160101.12

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ACS Style

Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Samba Ngano Odette; Mouelle Sone, et al. Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nucl. Sci. 2016, 1(1), 6-17. doi: 10.11648/j.ns.20160101.12

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AMA Style

Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mouelle Sone, et al. Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nucl Sci. 2016;1(1):6-17. doi: 10.11648/j.ns.20160101.12

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@article{10.11648/j.ns.20160101.12,
  author = {Kouam Foubi Brice Bertrand and Chuisseu Djamen Dieudonné Pascal and Dzeufiet Djomeni Paul Désiré and Samba Ngano Odette and Mouelle Sone and Ongolo Zogo Pierre and Dong à Zok Faustin and Yomi Jean and Juimo Alain George and Nko’o Amvene Samuel and Tiedeu Alain Bertin and Gonsu Fotsin Joseph},
  title = {Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome},
  journal = {Nuclear Science},
  volume = {1},
  number = {1},
  pages = {6-17},
  doi = {10.11648/j.ns.20160101.12},
  url = {https://doi.org/10.11648/j.ns.20160101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ns.20160101.12},
  abstract = {Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome
AU  - Kouam Foubi Brice Bertrand
AU  - Chuisseu Djamen Dieudonné Pascal
AU  - Dzeufiet Djomeni Paul Désiré
AU  - Samba Ngano Odette
AU  - Mouelle Sone
AU  - Ongolo Zogo Pierre
AU  - Dong à Zok Faustin
AU  - Yomi Jean
AU  - Juimo Alain George
AU  - Nko’o Amvene Samuel
AU  - Tiedeu Alain Bertin
AU  - Gonsu Fotsin Joseph
Y1  - 2016/12/27
PY  - 2016
N1  - https://doi.org/10.11648/j.ns.20160101.12
DO  - 10.11648/j.ns.20160101.12
T2  - Nuclear Science
JF  - Nuclear Science
JO  - Nuclear Science
SP  - 6
EP  - 17
PB  - Science Publishing Group
SN  - 2640-4346
UR  - https://doi.org/10.11648/j.ns.20160101.12
AB  - Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.
VL  - 1
IS  - 1
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