Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome
Nuclear Science
Volume 1, Issue 1, December 2016, Pages: 6-17
Received: Oct. 24, 2016; Accepted: Nov. 23, 2016; Published: Dec. 27, 2016
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Kouam Foubi Brice Bertrand, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Chuisseu Djamen Dieudonné Pascal, Faculty of Health Sciences, Université des Montagnes, Bangangté, Bangangté, Cameroon
Dzeufiet Djomeni Paul Désiré, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon
Samba Ngano Odette, Faculty of Sciences, University of Dschang, Dschang, Cameroon
Mouelle Sone, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Ongolo Zogo Pierre, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Dong à Zok Faustin, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Yomi Jean, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Juimo Alain George, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Nko’o Amvene Samuel, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Tiedeu Alain Bertin, National Advanced School of Engineering, University of Yaoundé I, Yaoundé, Cameroon
Gonsu Fotsin Joseph, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
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Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.
Irradiation, Radiation Syndrome, Prodromal Phase, AGE, Rats
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Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mouelle Sone, Ongolo Zogo Pierre, Dong à Zok Faustin, Yomi Jean, Juimo Alain George, Nko’o Amvene Samuel, Tiedeu Alain Bertin, Gonsu Fotsin Joseph, Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome, Nuclear Science. Vol. 1, No. 1, 2016, pp. 6-17. doi: 10.11648/j.ns.20160101.12
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