The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers
International Journal of Animal Science and Technology
Volume 1, Issue 1, December 2017, Pages: 5-14
Received: Oct. 30, 2017; Accepted: Nov. 16, 2017; Published: Jan. 3, 2018
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Lei Zhan, Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
Bing Wei, Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
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miR-203, as a member of the miRNAs family, play a major role in control of gene expression during normal development and are disrupted in the initiation and progression of specific diseases. It was worth nothing that a growing body of evidence indicated an abnormal expression of miR-203 in several human leading cancers including gastrointestinal and urogenital cancers. The cytosine-phosphoguanine (CpG)-island methylation was one of the most significant factors which controlled the expression of miR-203. Furthermore, miR-203 participated in these cancers via targeting its downstream genes. However, the precise regulatory mechanisms underlying miR-203 association with these cancers are still not fully understood. The aim of this review is to sum up the collective knowledge of miR-203 in gastrointestinal and urogenital cancers.
miR-203, Gastrointestinal Cancers, Urogenital Cancers, Methylation, Targeting
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Lei Zhan, Bing Wei, The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers, International Journal of Animal Science and Technology. Vol. 1, No. 1, 2017, pp. 5-14. doi: 10.11648/j.ijast.20170101.12
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