Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan

Almojtaba Abd Alkhalig Ahmed Bakheet; Asia Mohammed Elhassan

doi:doi:10.11648/j.ijhnm.20170303.11

| Peer-Reviewed

Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan

Almojtaba Abd Alkhalig Ahmed Bakheet, Asia Mohammed Elhassan

Published in International Journal of Homeopathy & Natural Medicines (Volume 3, Issue 3)

Received: 25 October 2017 Accepted: 9 November 2017 Published: 13 December 2017

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Malaria is a distressing health problem that posses a socio-economic burden of considerable magnitude for communities in developing countries. It causes some immunological and hematological changes particularly inflammatory biomarkers and hemoglobin. Research is extensively required in this area to promote health services and to target radical solution to the problem. The study was done to investigate some biomarkers and nutrients during malaria infections in Sudanese children in Sinar State-Sudan and how these biomarkers may relate to factors such as age and hemoglobin which in children may be important in disease progression and control. Thirty-two samples of blood were collected from 16 malaria patient from Sinar hospital and 16 apparently healthy individuals from the same area as control group from which serum was separated. The investigations were carried out to estimate serum C-reactive protein (CRP), tumor necrosis factor alpha (TNF α) and serum magnesium as a nutrient in the two groups. High sensitive and highly specific techniques were used for biomarker determinations. Results showed that children of different age groups with Malaria have significantly high levels of C-reactive protein, mean ± SE 5.93 ±1.52).

Published in	International Journal of Homeopathy & Natural Medicines (Volume 3, Issue 3)
DOI	10.11648/j.ijhnm.20170303.11
Page(s)	24-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Investigations, Biomarkers and Nutrients, Malaria Infection, Children

References

[1]	Mendis, K., Sina, B., Marchesini P. and Carter, R. (2000). The neglected burden of Plasmodium vivax malaria. Am. J. Trop. Med. Hyg., 64 (1-2 Suppl): 97-106.
[2]	Ubalee, R., Suzuki, F., Kikuchi, M., Tasanor, O., Wattanagoon, Y., Ruangweerayut, R., Na-Bangchang, K., Karbwang, J., Kimura, A., Itoh, K., Kanda, T. and Hirayama, K. (2001). Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar. Tissue Antigens, 58: 407-410.
[3]	Clark, I. A., Gray, K. M., Rockett, E. J., Cowden, W. B., Rockett, K. A., Ferrante, A. and Aggarwal, B. B. (1992). Increased lymphotoxin in human malarial serum, and the ability of this cytokine to increase plasma interleukin-6 and cause hypoglycaemia in mice – implications for malarial pathology. Trans. R. Soc. Trop. Med. Hyg., 86: 602-607.
[4]	Rudin, W., Eugster, H. P., Bordmann, G., Bonato, J., Muller, M., Yamage, M., and Ryffel, B. (1997). Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response. Am. J. Pathol. 150: 257-266.
[5]	Scharte M, Fink MP. Red blood cell physiology in critical illness. Crit Care Med. 2003; 31: S651–S657. [PubMed].
[6]	M, Muambi B, Mithwani S, Marsh K. Lactic acidosis and oxygen debt in african children with severe anaemia. Q J M. 1997; 90: 563–569. [PubMed].
[7]	Greenwood, B. M., Bojang, K., Whitty, C. J. and Targett, G. A. (2005). Malaria. Lancet, 365: 1487-1498.
[8]	Grover-Kopec, E., Kawano, M., Klaver, R., Blumenthal, B., Ceccato, P. and Connor, S.( 1998 ): An online operational rainfall-monitoring resource for epidemic malaria early warning systems in Africa. Malar. J., 4: 6.
[9]	Van Geertruyden, J., Thomas, F., Erhart, A. and D'Alessandro, U. (2004). The contribution of malaria in pregnancy to perinatal mortality. Am. J. Trop. Med. Hyg., 71 (2 Suppl): 35-40.
[10]	Boivin, M. J. (2002). Effects of early cerebral malaria on cognitive ability in Senegalese children. Journal of Developmental and Behavioral Pediatrics, 23, No. 5: 353-64.
[11]	Escalante, A. and Ayala, F. (1994). Phylogeny of the malarial genus Plasmodium, derived from rRNA gene sequences. Proc. Natl. Acad. Sci. U S A, 91 (24): 11373-7.
[12]	Mens, P. F., Schoone, G. J., Kager, P. A. and Schallig, H. D. F. H. (2006). Detection and identification of human Plasmodium species with real-time quantitative nucleic acid sequence-based amplification. Malaria Journal, 5 (80). DOI: 10.1186/1475-2875-5-80.
[13]	Van Benthem, B., Vanwambeke, S., Khantikul, N., Burghoorn-Maas, C., Panart, K., Oskam, L., Lambin, E. and Somboon, P. (2005). Spatial patterns of and risk factors for seropositivity for dengue infection. Am. J. Trop. Med. Hyg., 72 (2): 201-8.
[14]	Beare, N. A. (2006). Malaria in developing countries. J Trop. Med. Hyg., 75 (5): 790-797.
[15]	Ridker, P. M., Rifai, N. and Rose L. (2002). Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N. Engl. J. Med., 347: 1557-1565.
[16]	Imrie, H., Fowkes, F. J., Michon, P., Tavul, L., Reeder, J. C. and Day, K. P. (2007). Low prevalence of an acute phase response in asymptomatic children from a malaria-endemic area of Papua New Guinea. Am. J. Trop. Med. Hyg., 76 (2): 280-284.
[17]	Naylor, S. (2003). Current perspectives and future prospects. Expert Rev. Mol. Diagn., 3: 525-529.
[18]	Sinha, S., Mishra, S. K., Sharma, S., Patibandla, P. K., Mallick, P. K., Sharma, S. K., Mohanty, S., Pati, S. S., Mishra, S. K., Ramteke, B. K., Bhatt, R., Joshi, H., Dash, A. P., Ahuja, R. C. and Awasthi, S. (2008). Indian Genome Variation Consortium, Venkatesh Vv. Habib SPolymorphisms of TNF-enhancer and gene for Fcgamma RIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population. Malar. J., 7: 13.
[19]	Carter, J. A., Ross, A. J., Neville, B. G., Obiero, E., Katana, K., Mung'ala-Odera, V., Lees, J. A. and Newton, C. R. (2005): Developmental impairments following severe falciparum malaria in children. Trop. Med. Int. Health, 10: 3-10.
[20]	Kabyemela, E. R., Muehlenbachs, A., Fried, M., Kurtis, J. D., Mutabingwa, T. K. and Duffy, P. E. (2008). Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria. Malar. J., 7: 26.
[21]	Anderson, T. J., Haubold, B., Williams, J. T., Estrada-Franco, J. G., Richardson, L., Mollinedo, R., Bockarie, M., Mokili, J., Mharakurwa, S., French, N., Whitworth, J., Velez, I. D., Brockman, A. L., Nosten, F., Ferreira, M. U. and Day, K. P. (2007). Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol. Biol. Evol., 17 (10): 1467-1482.

Cite This Article

Plain Text BibTeX RIS

APA Style

Almojtaba Abd Alkhalig Ahmed Bakheet, Asia Mohammed Elhassan. (2017). Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan. International Journal of Homeopathy & Natural Medicines, 3(3), 24-30. https://doi.org/10.11648/j.ijhnm.20170303.11

Copy | Download

ACS Style

Almojtaba Abd Alkhalig Ahmed Bakheet; Asia Mohammed Elhassan. Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan. Int. J. Homeopathy Nat. Med. 2017, 3(3), 24-30. doi: 10.11648/j.ijhnm.20170303.11

Copy | Download

AMA Style

Almojtaba Abd Alkhalig Ahmed Bakheet, Asia Mohammed Elhassan. Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan. Int J Homeopathy Nat Med. 2017;3(3):24-30. doi: 10.11648/j.ijhnm.20170303.11

Copy | Download

@article{10.11648/j.ijhnm.20170303.11,
  author = {Almojtaba Abd Alkhalig Ahmed Bakheet and Asia Mohammed Elhassan},
  title = {Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan},
  journal = {International Journal of Homeopathy & Natural Medicines},
  volume = {3},
  number = {3},
  pages = {24-30},
  doi = {10.11648/j.ijhnm.20170303.11},
  url = {https://doi.org/10.11648/j.ijhnm.20170303.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhnm.20170303.11},
  abstract = {Malaria is a distressing health problem that posses a socio-economic burden of considerable magnitude for communities in developing countries. It causes some immunological and hematological changes particularly inflammatory biomarkers and hemoglobin. Research is extensively required in this area to promote health services and to target radical solution to the problem. The study was done to investigate some biomarkers and nutrients during malaria infections in Sudanese children in Sinar State-Sudan and how these biomarkers may relate to factors such as age and hemoglobin which in children may be important in disease progression and control. Thirty-two samples of blood were collected from 16 malaria patient from Sinar hospital and 16 apparently healthy individuals from the same area as control group from which serum was separated. The investigations were carried out to estimate serum C-reactive protein (CRP), tumor necrosis factor alpha (TNF α) and serum magnesium as a nutrient in the two groups. High sensitive and highly specific techniques were used for biomarker determinations. Results showed that children of different age groups with Malaria have significantly high levels of C-reactive protein, mean ± SE 5.93 ±1.52).},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan
AU  - Almojtaba Abd Alkhalig Ahmed Bakheet
AU  - Asia Mohammed Elhassan
Y1  - 2017/12/13
PY  - 2017
N1  - https://doi.org/10.11648/j.ijhnm.20170303.11
DO  - 10.11648/j.ijhnm.20170303.11
T2  - International Journal of Homeopathy & Natural Medicines
JF  - International Journal of Homeopathy & Natural Medicines
JO  - International Journal of Homeopathy & Natural Medicines
SP  - 24
EP  - 30
PB  - Science Publishing Group
SN  - 2472-2316
UR  - https://doi.org/10.11648/j.ijhnm.20170303.11
AB  - Malaria is a distressing health problem that posses a socio-economic burden of considerable magnitude for communities in developing countries. It causes some immunological and hematological changes particularly inflammatory biomarkers and hemoglobin. Research is extensively required in this area to promote health services and to target radical solution to the problem. The study was done to investigate some biomarkers and nutrients during malaria infections in Sudanese children in Sinar State-Sudan and how these biomarkers may relate to factors such as age and hemoglobin which in children may be important in disease progression and control. Thirty-two samples of blood were collected from 16 malaria patient from Sinar hospital and 16 apparently healthy individuals from the same area as control group from which serum was separated. The investigations were carried out to estimate serum C-reactive protein (CRP), tumor necrosis factor alpha (TNF α) and serum magnesium as a nutrient in the two groups. High sensitive and highly specific techniques were used for biomarker determinations. Results showed that children of different age groups with Malaria have significantly high levels of C-reactive protein, mean ± SE 5.93 ±1.52).
VL  - 3
IS  - 3
ER  -

Copy | Download

Author Information

Almojtaba Abd Alkhalig Ahmed Bakheet

Department of Family Sciences, Faculty of Education, University of Khartoum, Khartoum, Sudan; Department of Biochemistry, Faculty of Veterinary Medicine, University of Khartoum, Khartoum, Sudan
Asia Mohammed Elhassan

Department of Biochemistry, Faculty of Veterinary Medicine, University of Khartoum, Khartoum, Sudan

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Almojtaba Abd Alkhalig Ahmed Bakheet, Asia Mohammed Elhassan. (2017). Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan. International Journal of Homeopathy & Natural Medicines, 3(3), 24-30. https://doi.org/10.11648/j.ijhnm.20170303.11

Copy | Download

ACS Style

Almojtaba Abd Alkhalig Ahmed Bakheet; Asia Mohammed Elhassan. Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan. Int. J. Homeopathy Nat. Med. 2017, 3(3), 24-30. doi: 10.11648/j.ijhnm.20170303.11

Copy | Download

AMA Style

Almojtaba Abd Alkhalig Ahmed Bakheet, Asia Mohammed Elhassan. Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan. Int J Homeopathy Nat Med. 2017;3(3):24-30. doi: 10.11648/j.ijhnm.20170303.11

Copy | Download

@article{10.11648/j.ijhnm.20170303.11,
  author = {Almojtaba Abd Alkhalig Ahmed Bakheet and Asia Mohammed Elhassan},
  title = {Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan},
  journal = {International Journal of Homeopathy & Natural Medicines},
  volume = {3},
  number = {3},
  pages = {24-30},
  doi = {10.11648/j.ijhnm.20170303.11},
  url = {https://doi.org/10.11648/j.ijhnm.20170303.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhnm.20170303.11},
  abstract = {Malaria is a distressing health problem that posses a socio-economic burden of considerable magnitude for communities in developing countries. It causes some immunological and hematological changes particularly inflammatory biomarkers and hemoglobin. Research is extensively required in this area to promote health services and to target radical solution to the problem. The study was done to investigate some biomarkers and nutrients during malaria infections in Sudanese children in Sinar State-Sudan and how these biomarkers may relate to factors such as age and hemoglobin which in children may be important in disease progression and control. Thirty-two samples of blood were collected from 16 malaria patient from Sinar hospital and 16 apparently healthy individuals from the same area as control group from which serum was separated. The investigations were carried out to estimate serum C-reactive protein (CRP), tumor necrosis factor alpha (TNF α) and serum magnesium as a nutrient in the two groups. High sensitive and highly specific techniques were used for biomarker determinations. Results showed that children of different age groups with Malaria have significantly high levels of C-reactive protein, mean ± SE 5.93 ±1.52).},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Investigations of Some Biomarkers and Nutrients During Malaria Infection in Children in Sinar State-Sudan
AU  - Almojtaba Abd Alkhalig Ahmed Bakheet
AU  - Asia Mohammed Elhassan
Y1  - 2017/12/13
PY  - 2017
N1  - https://doi.org/10.11648/j.ijhnm.20170303.11
DO  - 10.11648/j.ijhnm.20170303.11
T2  - International Journal of Homeopathy & Natural Medicines
JF  - International Journal of Homeopathy & Natural Medicines
JO  - International Journal of Homeopathy & Natural Medicines
SP  - 24
EP  - 30
PB  - Science Publishing Group
SN  - 2472-2316
UR  - https://doi.org/10.11648/j.ijhnm.20170303.11
AB  - Malaria is a distressing health problem that posses a socio-economic burden of considerable magnitude for communities in developing countries. It causes some immunological and hematological changes particularly inflammatory biomarkers and hemoglobin. Research is extensively required in this area to promote health services and to target radical solution to the problem. The study was done to investigate some biomarkers and nutrients during malaria infections in Sudanese children in Sinar State-Sudan and how these biomarkers may relate to factors such as age and hemoglobin which in children may be important in disease progression and control. Thirty-two samples of blood were collected from 16 malaria patient from Sinar hospital and 16 apparently healthy individuals from the same area as control group from which serum was separated. The investigations were carried out to estimate serum C-reactive protein (CRP), tumor necrosis factor alpha (TNF α) and serum magnesium as a nutrient in the two groups. High sensitive and highly specific techniques were used for biomarker determinations. Results showed that children of different age groups with Malaria have significantly high levels of C-reactive protein, mean ± SE 5.93 ±1.52).
VL  - 3
IS  - 3
ER  -

Copy | Download