Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats
International Journal of Homeopathy & Natural Medicines
Volume 5, Issue 1, June 2019, Pages: 18-29
Received: Mar. 8, 2019; Accepted: Apr. 13, 2019; Published: May 20, 2019
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Authors
Mahmoud Ibrahim El-Sayed, Department of Dairy Technology Research, Food Technology Research Institute, ARC, Giza, Egypt
Sameh Awad, Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
Mokhtar Yousef, Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
Abdelmonem Wahba, Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
Aisha El Attar, Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
Mostafa Zedan, Department of Dairy Technology Research, Food Technology Research Institute, ARC, Giza, Egypt
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Abstract
Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (P<0.05) increased the final body weight of normal rats and improved the body weight of diabetic rats and significantly protective (P<0.05) the liver, kidney, heart and lung of normal rats and reduced the fallers of these organs in diabetic rats. The diabetes groups treated by MPCH showed improvement in RBC, Hb, Ht and PLT values. Meanwhile WBC not affected. The oral intake of MPCH protected the normal range of Lymphocytes and S. Nutrophils in healthy and diabetic rats. The oral intake of MPCH caused significant (P<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.
Keywords
Milk Protein, Protein Hydrolysate, Bioactive Peptides, T2 Diabetes
To cite this article
Mahmoud Ibrahim El-Sayed, Sameh Awad, Mokhtar Yousef, Abdelmonem Wahba, Aisha El Attar, Mostafa Zedan, Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats, International Journal of Homeopathy & Natural Medicines. Vol. 5, No. 1, 2019, pp. 18-29. doi: 10.11648/j.ijhnm.20190501.14
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Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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