Journal of Diseases and Medicinal Plants
Volume 1, Issue 1, April 2015, Pages: 19-23
Received: Apr. 20, 2015;
Accepted: Apr. 24, 2015;
Published: Apr. 30, 2015
Views 4385 Downloads 387
Tagne Simo Richard, Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere, Cameroon
Armel Herve Nwabo Kamdje, Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere, Cameroon
Farah Mukhtar, Department of International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Various active compounds (or their semi-synthetic derivatives) derived from medicinal plants have been assessed for their efficacy and tolerability in the treatment of breast cancer. Some of these plant species, including Taxus baccata (paclitaxel, docetaxel), Podophyllum peltatum (etoposide), Camptotheca acuminata (camptothecin) and Vinca rosea (vinblastine, vinorelbine) have well recognized antitumour activity in breast cancer, and have been evaluated in clinical trials. For example, results from recent Phase II/III trials have established docetaxel as the most active single agent in the treatment (first or second-line) of advanced metastatic breast cancer. The treatment of breast cancer, the most common malignancy among women worldwide, remains puzzling partly due to the resistance to therapeutics, which associates with the heterogeneity of case clinical presentations, and limits in the current understanding of the pathogenesis of solid cancers. Oxidative stress is closely related to various diseases, including cancer. The human body is exposed to free radicals, which cause oxidative stress. Oxidative stress may lead to gene mutations leading to carcinogenesis. Antioxidants are protector of the body, preventing oxidative stress, by stabilizing free radicals. Plants are good and cheap sources for the prevention and treatment of oxidative stress and cancer. Major drawbacks to Antioxidant from plants -based therapy and use in breast cancer are herein briefly discussed.
Tagne Simo Richard,
Armel Herve Nwabo Kamdje,
Medicinal Plants in Breast Cancer Therapy, Journal of Diseases and Medicinal Plants.
Vol. 1, No. 1,
2015, pp. 19-23.
Halliwell B, Gutteridge J (2007) Free radicals in biology and medicine. (4th Edn), Oxford University Press, Oxford, USA.
Clarkson PM, Thompson HS (2000) Antioxidants: what role do they play in physical activity and health Am J Clin Nutr 72: 637S-646S.
Feher J, Csomos G, Vereckei A (1987) Free radical reactions in medicine. Springer-Verlag, Berlin-Heidelberg, USA 40-43.
de Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP (1999) Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic Biol Med 26: 202-226.
Berlett BS, Stadtman ER (1997) Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272: 20313-20316.
Dean RT, Fu S, Stocker R, Davies MJ (1997) Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 324 : 1-18.
Morabito MA, Sheng M, Tsai LH (2004) Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. J Neurosci 24: 865-876.
Benderitter M, Maupoil V, Vergely C, Dalloz F, Briot F, et al. (1998) Studies by electron paramagnetic resonance of the importance of iron in the hydroxyl scavenging properties of ascorbic acid in plasma: effects of iron chelators. Fundam Clin Pharmacol 12: 510-516.
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, et al. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 7 : 44-84.
Powell JM, McCrory DF, Jackson-Smith DB, Saam H (2005) Manure collection and distribution on Wisconsin dairy farms. J Environ Qual 34: 2036-2044.
Cerutti PA (1994) Oxy-radicals and cancer. Lancet 344: 862-863.
Cook PLM, Wenzhöfer F, Rysgaard S, Galaktionov OS, Meysman FJR, et al. (2006)Quantification of denitrification in permeable sediments: Insights from a two dimensional simulation analysis and experimental data. Limnol Oceanogr Methods 4: 294-307.
Cook A, Blaustein M, Spinazzola J, van der Kolk B (2003) Complex trauma in children and adolescents. National Child Traumatic Stress Network, Complex Trauma Taskforce.
Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420: 860-867.
. Vickers A (2002) Botanical medicines for the treatment of cancer: rationale, overview of current data, and methodological considerations for phase I and II trials. Cancer Invest 20: 1069-1079.
Bonham M, Arnold H, Montgomery B, Nelson PS (2002) Molecular effects of the herbal compound PC-SPES: identification of activity pathways in prostate carcinoma. Cancer Res 62: 3920-3924.
Hu H, Ahn NS, Yang X, Lee YS, Kang KS (2002) Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer 102: 250-253.
El-Shemy HA, Aboul-Enein AM, Aboul-Enein MI, Issa SI, Fujita K (2003) The effect of willow leaf extracts on human leukemic cells in vitro. J Biochem Mol Biol 36: 387-389.
Kao ST, Yeh CC, Hsieh CC, Yang MD, Lee MR, et al. (2001)The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest. Life Sci 69: 1485-1496.
Meyers KJ, Watkins CB, Pritts MP, Liu RH (2003) Antioxidant and antiproliferative activities of strawberries. J Agric Food Chem 51: 6887-6892.
Yano H, Mizoguchi A, Fukuda K, Haramaki M, Ogasawara S, et al. (1994) The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res 54: 448-454.
Wang X, Wei L, Ouyang JP, Muller S, Gentils M, et al. (2001) Effects of an angelica extract on human erythrocyte aggregation, deformation and osmotic fragility. Clin Hemorheol Microcirc 24: 201-205.
Xie F, Li X, Sun K, Chu Y, Cao H, et al. (2001) An experimental study on drugs for improving blood circulation and removing blood stasis in treating mild chronic hepatic damage. J Tradit Chin Med 21: 225-231.
Poma A, Miranda M, Spanò L (1998) Differential response of human melanoma and Ehrlich ascites cells in vitro to the ribosome-inactivating protein luffin. Melanoma Res 8: 465-467.
Ma H, Carpenter CL, Sullivan-Halley J, Bernstein L (2011) The roles of herbal remedies in survival and quality of life among long-term breast cancer survivors-results of a prospective study. BMC Cancer 11: 222.
Olaku O, White JD (2010) Herbal therapy use by cancer patients: A literature review on case reports. Eur J Cancer [Article in Press].
Sakarkar DM, Deshmukh VN (2011) Ethnopharmacological Review of Traditional Medicinal Plants for Anticancer Activity. International Journal of PharmTech Research 3: 298-308.
Boon H, Stewart M, Kennard MA, Gray R, Sawka C, et al. (2000) Use of complementary/alternative medicine by breast cancer survivors in Ontario: prevalence and perceptions. J Clin Oncol 18: 2515-2521.
Burstein HJ, Gelber S, Guadagnoli E, Weeks JC (1999) Use of alternative medicine by women with early-stage breast cancer. N Engl J Med 340: 1733-1739.
Michael JW, Cynthia W, Destiny MH, Mary EZ (2001) Herbals, Cancer Prevention and Health. American Society for Nutritional Sciences, Journal of Nutrition 131: 3034?3036.
Kwak MK, Egner PA, Dolan PM, Ramos GM, Groopman JD, et al. (2001) Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res 480-481: 305-315.
Fleischauer AT, Arab L (2001) Garlic and cancer: a critical review of the epidemiologic literature. J Nutr 131: 1032S-40S.